BPS2024 Full Program & Abstracts

Platform Cryo-EM: From Atoms to Brains 4:00 pm - 6:00 pm, Room 113AB

987-Symp 5:30 pm RNA RECODING IN CEPHALOPODS TAILORS MICROTUBULE MOTOR PROTEIN FUNCTION. Kavita J. Rangan , Samara L. Reck-Peterson Platform Protein-Nucleic Acid Interactions I 4:00 pm - 6:00 pm, Room 103AB Co-Chairs Kaixian Liu, Memorial Sloan Kettering Cancer Center, USA Evgenia Nikolova, Johns Hopkins University, USA 988 -Plat 4:00 pm ZNF598’S RECRUITMENT DYNAMICS IN RIBOSOME-ASSOCIATED PROTEIN QUALITY CONTROL REVEALED THROUGH SINGLE-MOLECULE IMAGING. Ana C. De La Cruz , Emily Nakayama, Bin Wu 989 -Plat 4:15 pm NUCLEAR EXPORT DYNAMICS OF PRE-RIBOSOMAL SUBUNITS RE VEALED BY HIGH-SPEED SINGLE-MOLECULE MICROSCOPY IN LIVE CELLS. Samuel L. Junod , Mark Tingey, Joseph Kelich, Alexander Goryaynov, Karl Herbine, Weidong Yang 990 -Plat 4:30 pm FRAMESHIFT-PROMOTING PK INDUCES A HYPER-ROTATED AND ROLLED 70S RIBOSOME. Christopher Llynard D. Ortiz , Irene Deli, Yi-Lan Chen, Jin-Der Wen, Ming-Daw Tsai, Lee-Wei Yang 991-Plat 4:45 pm HIBERNATING RIBOSOMES TETHER TO MITOCHONDRIA AS AN ADAP TIVE RESPONSE TO CELLULAR STRESS DURING GLUCOSE DEPLETION. Ahmad Jomaa 992 -Plat 5:00 pm SOX2 AND DNA FLEXIBILITY DICTATE NUCLEOSOME ENGAGEMENT AND SOX2-OCT4 SYNERGISM. Evgenia N. Nikolova , Fabiana C. Malaga Gadea 993 -Plat 5:15 pm A NOVEL TRNA FEATURE FOUND IN AN ARCHAEAL PYRROLYSYL TRNA IS A REQUIREMENT FOR PYLRS RECOGNITION. Jingji Zhang, Natalie Krahn , Sergey V. Melnikov, Jeffery M. Tharp, Alessandra Villa, Armaan Patel, Rebecca J. Howard, Haben Gabir, Trushar R. Patel, Jörg Stetefeld, Joseph D. Puglisi, Dieter Söll 994 -Plat 5:30 pm Travel Award Winner MECHANISTIC INSIGHTS INTO CRISPR-CAS12F1 REVEALED THROUGH SINGLE-MOLECULE AND BIOCHEMICAL STUDIES. Julene Madariaga Marcos , Dominik J. Kauert, Selgar Henkel-Heinecke, Patrick Irmisch, Greta Bigelyte, Tautvydas Karvelis, Virginijus Siksnys, Ralf Seidel 995-FlashTalk 5:45 pm HP1-DNA CONDENSATE DYNAMICS: INSIGHT INTO CHROMATIN COMPACTION MECHANISM. Abhinaw Kumar , Dinesh Sundaravadivelu Devarajan, Tien M. Phan, Jeetain Mittal 996-FlashTalk 5:50 pm STRUCTURE AND DNA BRIDGING ACTIVITY OF THE ESSENTIAL REC114 MEI4 TRIMER INTERFACE. Kaixian Liu , Emily M. Grasso, Stephen Pu, Mengyang Zou, Shixin Liu, David Eliezer, Scott Keeney 997-FlashTalk 5:55 pm PROTECTION OF DNA FROM MECHANICAL STRESSES AT THE NUCLEAR ENVELOPE. Ramesh Adakkattil

M O N D A Y

Co-Chairs Yue Yu, Chan Zuckerberg Imaging Institute, USA Sergio Cruz-Leon, Max Planck Institute of Biophysics, Germany 998 -Plat 4:00 pm ADVANCES IN 4D-STEM PHASE-CONTRAST IMAGING OF FROZEN-HY DRATED BIOLOGICAL SPECIMENS. Yue Yu , Michael Colletta, Katherine Spoth, David Muller, Lena Kourkoutis 999 -Plat 4:15 pm CRYO-EM STRUCTURES OF NANODISC RECONSTITUTED PROKARYOTIC LIGAND-GATED ION CHANNEL GLIC IN VARIOUS CONFORMATIONS REVEAL STATE-DEPENDENT PROTEIN-LIPID INTERACTIONS AND GATING MECHANISM. Nikhil Bharambe, Zhuowen Li, David Seiferth, Asha Man ikkoth Balakrishna, Philip C. Biggin, Sandip Basak 1000-Plat 4:30 pm CRYO ELECTRON TOMOGRAPHY ON EUKARYOTIC PLASMA MEM BRANES. Willy W. Sun, Dennis J. Michalak, Prasanthi Kunamaneni, Jenny E. Hinshaw, Justin W. Taraska, Kem A. Sochacki 1001-Plat 4:45 pm HIGH-CONFIDENCE 3D TEMPLATE MATCHING FOR CRYO-ELECTRON TOMOGRAPHY. Sergio Cruz-Leon , Tomáš Majtner, Patrick Hoffmann, Jan P. Kreysing, Maarten W. Tuijtel, Stefan L. Schaefer, Katharina Geißler, Martin Beck, Beata Turoňová, Gerhard Hummer 1002-Plat 5:00 pm USING TEMPERATURE-RESOLVED CRYO-EM TO DECIPHER MECHANISM OF THERMOREGULATION BY RYR. Harsh Bansia , Zephan Melville, An drew R. Marks, amedee des Georges 1003-Plat 5:15 pm A HIGH RESOLUTION LOOK AT FRESH HUMAN BRAIN VITRIFIED DI RECTLY FROM AUTOPSY USING CRYO-ELECTRON TOMOGRAPHY WITH CRYO-PLASMA FOCUSED ION BEAM MILLING. Benjamin C. Creekmore , Kathryn Kixmoeller, Ben E. Black, Edward B. Lee, Yi-Wei Chang 1004-Plat 5:30 pm UNCOVERING THE PROTEIN STRUCTURAL ENSEMBLE BY INTEGRATING MOLECULAR MODELING WITH CRYO-EM. David Silva-Sánchez, Jake Moomaw, Wai Shing Tang, Sonya M. Hanson, Roy Lederman, Pilar Cos sio, Erik H. Thiede 1005-FlashTalk 5:45 pm CRYO-EM STRUCTURE OF A 55 KDA NUCLEOPLASMIN PROTEIN. Nikhil Bharambe , Ketul Saharan, Dileep Vasudevan, Sandip Basak 1006-FlashTalk 5:50 pm SPOT-RASTR - A CRYO-EM SPECIMEN PREPARATION TECHNIQUE THAT OVERCOMES PROBLEMS WITH PREFERRED ORIENTATION AND THE AIR/ WATER INTERFACE. Behrouz Ghazi Esfahani , Peter S. Randolph, Ruizhi Peng, Elizabeth Stroupe, Tim Grant, Scott M. Stagg 1007-FlashTalk 5:55 pm COMPUTATIONAL ANALYSIS OF LIGANDS ENABLES NEAR-ATOMIC CRYO EM STRUCTURE-BASED DRUG DESIGN (CRYO-EM SBDD). Qiu-Xing Jiang , Ceng Gao, Gaya P. Yadav, Zhuoya Wang, Shuai Yang

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