BPS2024 Full Program & Abstracts

Platform Protein-Small Molecule Interactions 4:00 pm - 6:00 pm, Room 201AB

Platform Membrane Dynamics 4:00 pm - 6:00 pm, Room 204AB

M O N D A Y

Co-Chairs Alice Romagnoli, Marche Polytechnic University , Italy Louis Smith, University of Pennsylvania, USA 1008-Plat 4:00 pm

Co-Chairs Yein Christina Park, NIH, USA Petia Vlahovska, Northwestern University, USA 1018-Plat 4:00 pm

Travel Award Winner

TRANSLATIONAL TAKEDOWN: CYFIP1-BASED PEPTIDOMIMETIC AGAINST CANCER AND FRAGILE X SYNDROME. Alice Romagnoli , Stefano Raniolo, Alessandro Gori, Anastasia De Luca, Vittorio Limongelli, Daniele Di Marino 1009-Plat 4:15 pm IN SILICO DESIGNING OF MAD2L2-REV1 COMPLEX INHIBITOR ENHANC ES CELL DEATH BY CHEMOTHERAPY. Dror Tobi , Tamar Listovsky 1010-Plat 4:30 pm STRUCTURAL INSIGHTS INTO TARGETED DEGRADATION OF CASEIN KINASE 1-Α. Sarah Young , Gisele Nishiguchi, Sherif Abdelhamed, Elizabeth Caine, Lauren Mascibroda, Jeffrey Kooijman, Darcie Miller, Kevin McGowan, Anand Mayasundari, Zhe Shi, Anup Aggarwal, Marcus Fischer, Jeffery Klco, Zoran Rankovic 1011-Plat 4:45 pm BINDING SMALL MOLECULE DRUGS MAY AVOID PROTEIN MISFOLDING INTO NON-COVALENT LASSO ENTANGLEMENTS. Yang Jiang , Edward P. O'Brien 1012-Plat 5:00 pm SMALL MOLECULE ALLOSTERIC MODULATORS OF THE amL-ASSOCIATED SRC-FAMILY KINASE, HCK. Ari M. Selzer , Gabriella J. Gerlach, Giancarlo Gonzalez-Areizaga, Thomas E. Wales, Carlos J. Camacho, Rieko Ishima, John R. Engen, Thomas E. Smithgall 1013-Plat 5:15 pm canceled MOLECULAR INSIGHTS INTO THE NEUROPROTECTIVE EFFECTS OF CHLOROGENIC ACIDS MEDIATED BY THE PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR PPARALPHA. Mercedes Alfonso Prieto , Nicolas P.F. Mueller, Olga A. Sergeeva, Luciano Navarini, Paolo Carloni 1014-Plat 5:30 pm POPSHIFT: A THERMODYNAMICALLY SOUND APPROACH TO ESTIMATE BINDING FREE ENERGIES BY ACCOUNTING FOR LIGAND-INDUCED POPULATION SHIFTS FROM A LIGAND-FREE MSM. Louis G. Smith , Borna Novak, Meghan Osato, David L. Mobley, Gregory R. Bowman 1015-FlashTalk 5:45 pm LIQUID-LIQUID PHASE SEPARATION INDUCED BY INTERACTIONS BETWEEN THE PICORNAVIRUS 3C(D) MAIN PROTEASE AND GENOMIC RNA CONTROL ELEMENTS. Somnath Mondal , Kevin E.W. Namitz, Neela Yennawar, David D. Boehr 1016-FlashTalk 5:50 pm IDENTIFYING AND CHARACTERIZING HYDROPHILIC PROTEIN SURFACE PATCHES WITH MOLECULAR DYNAMICS SIMULATIONS. Lilia F. Escobe do , Nicholas B. Rego, Daeyeon Lee, amish J. Patel 1017-FlashTalk 5:55 pm OPEN-COMBIND: HARNESSING UNLABELED DATA FOR IMPROVED BIND ING POSE PREDICTION. Andrew T. McNutt , David R. Koes

SPONTANEOUS CURVATURE GENERATION BY PEPTIDES IN ASYMMETRIC BILAYERS. Soohyung Park , amy Rice, Wonpil Im, Richard W. Pastor 1019-Plat 4:15 pm HOW LATERAL TENSION AND LIPID REDISTRIBUTION INFLUENCE MEM BRANE DEFORMATION ENERGETICS. Yein C. Park , Giacomo Fiorin, José D. Faraldo-Gómez 1020-Plat 4:30 pm PROBING WRAPPING DYNAMICS OF SPHERICAL NANOPARTICLES BY 3D VESICLES USING FORCE-BASED SIMULATIONS. Didarul Ahasan Redwan , Xin Yong, Ke Du 1021-Plat 4:45 pm NANOSCALE DYNAMICS OF HOST CELL PLASMA MEMBRANE DURING VIRUS INTERNALIZATION AS VISUALIZED BY LIVE-CELL ATOMIC FORCE MICROSCOPY. Aiko Yoshida , Nobuaki Sakai, Yoshitsugu Uekusa, Takeshi Suzuki, Yamauchi Yohei, Yusuke Ohba 1022-Plat 5:00 pm EXPERIMENTAL STUDY AND MODELING OF DIFFUSION OF SK CHANNELS IN UNMYELINATED NEURONS. George Lykotrafitis , Shiju Gu, Anastasios 5:15 pm THE STRUCTUAL BASIS OF NINJ1-MEDIATED PLASMA MEMBRANE RUP TURE. Bibekananda Sahoo, Zongjun Mou, Wei Liu, George R. Dubyak, Xinghong Dai 1024-Plat 5:30 pm MEMBRANE FISSION DURING BACTERIAL SPORE DEVELOPMENT REQUIRES CELLULAR INFLATION DRIVEN BY DNA TRANSLOCATION. Ane Landajuela , Martha Braun, Alejandro Martínez-Calvo, Christopher D.A. Rodrigues, Carolina Gomis Perez, Thierry Doan, Daivd Rudner, Ned S.Wingreen, Erdem Karatekin 1025-FlashTalk 5:45 pm Travel Award Winner BIO-INSPIRED ARTIFICIAL SYNAPSE WITH CHEMICALLY MEDIATED INTERCOMPARTMENT COMMUNICATION FOR SINGLE MOLECULE CELL SYNTHETIC CELL INTERACTION STUDIES. Aspasia Zoupa , William D. Jamieson, Jared Whitehead, Arwyn T. Jones, Oliver K. Castell 1026-FlashTalk 5:50 pm OSMOCYTOSIS: OSMOTICALLY INDUCED GENERATION AND PULSATORY PORATION OF PINOCYTIC VESICLES INSIDE GIANT VESICLES. Pallavi D. Sambre , James C. S. Ho, Atul N. Parikh 1027-FlashTalk 5:55 pm THE CORTICAL ACTIN CYTOSKELETON REGULATES MEMBRANE PROTEIN ORGANIZATION AND DYNAMICS. Shambhavi Pandey , Thorsten Woh land Tzingounis 1023-Plat

74