BPS2024 Full Program & Abstracts

Platform Membrane 8:15 am - 10:15 am, Room 113AB

1676-Plat 8:30 am A NEWLY PREDICTED CLASS OF PROTEIN MISFOLDING EXPLAINS DECADES-OLD BIOCHEMICAL AND MOLECULAR BIOLOGY DATA. Edward 8:45 am INVESTIGATING THE CHAPERONE MECHANISM OF Α-CRYSTALLIN IN PREVENTING ΓD-CRYSTALLIN AGGREGATION IN CATARACT FORMATION. Deepshikha Ghosh 1678-Plat 9:00 am MOLECULAR CHAPERONES AND THEIR ROLE IN amYLOID FORMATION. Matthias M. Schneider , Andreas Bracher, Ewa A. Andrzejewska, Georg Krainer, Li-Uen Lin, Roland Riek, Ulrich Hartl, Tuomas P.J. Knowles 1679-Plat 9:15 am AP PROFILING RESOLVES CO-TRANSLATIONAL FOLDING PATHWAYS AND CHAPERONE INTERACTIONS IN VIVO. Xiuqi Chen, Christian M. Kaiser 1680-Plat 9:30 am EARLY FORMED NON-LOCAL CONTACTS ARE “NATURES-SHORTCUTS” TO FAST PROTEIN FOLDING. Elisha Haas , Gil Rahamim, Dan am ir 1681-Plat 9:45 am Travel Award Winner STUDYING THE ENTROPIC PULLING OF HSP70 AT THE SINGLE-MOLE CULE LEVEL USING A NANOPORE. Verena Rukes , Mathieu E. Rebeaud, Paolo De Los Rios, Chan Cao 1682-FlashTalk 10:00 am HYDROGEN BOND STABILIZES LIPID-ACCESSIBLE POLAR RESIDUES IN MEMBRANE PROTEINS. Lucas Shen , Karen G. Fleming 1683-FlashTalk 10:05 am STABILITY VS. ENVIRONMENTAL SENSITIVITY: THE IMPORTANCE OF PRO TEIN SURFACE CHARGE ADAPTATIONS. Edward Knab , Matthew Sternke, Doug Barrick, Martin Gruebele, Caitlin Davis 1684-FlashTalk 10:10 am BINDING AFFINITY AND SPECIFICITY OF OPACITY-ASSOCIATED PROTEINS AND HUMAN CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULES. Connor McDermott , Meagan Belcher Dufrisne, Linda M. Columbus Platform Membrane Fusion and Structure 8:15 am - 10:15 am, Room 204AB Co-Chairs Alexander Sodt, NIH, USA Raya Sorkin, Tel Aviv University, Israel 1685-Plat 8:15 am MEMBRANE TENSION INHIBITS LIPID MIXING BY INCREASING THE HEM IFUSION STALK ENERGY. Petr Shendrik, Gonen Golani, Raviv Dharan, Ulrich S. Schwarz, Raya Sorkin 1686-Plat 8:30 am HEMIFUSION DIAPHRAGM SIMULATIONS SUGGEST A MOLECULAR MECHANISM OF IFITM3 ANTIVIRAL ACTIVITY. Andrew H. Beaven, am i rali Hossein, Kazi Rahman, Alex Compton, Alexander J. Sodt 1687-Plat 8:45 am MECHANISMS TO CONTROL MEMBRANE FUSION ENERGY BARRIERS BY VIRUS AND HOST. Gonen Golani , Fabio Lolicato, Steffen Klein, Sophie Winter, Petr Chlanda, Ulrich S. Schwarz 1688-Plat 9:00 am DNA-PROGRAMMED SURFACE DISPLAY OF RECEPTORS TO DISSECT THE FUNCTIONAL INTERPLAY BETWEEN RECEPTOR BINDING AND MEM - P. O’Brien 1677-Plat

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Co-Chairs Valeria Kalienkova, University of Bergen, Norway Dagan Marx, Weill Cornell Medical College, USA 1665-Plat 8:15 am

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MOLECULAR DETERMINANTS OF ARRESTIN BINDING TO DIMERIC GPCRS. Dagan C. Marx , Joon Lee, Alexa Strauss, Kevin Huynh, David Eliezer, Josh Levitz 1666-Plat 8:30 am QUANTITATIVE ANALYSIS OF STEROL MODULATED MONOMER-DIMER EQUILIBRIUM OF ß 1 -ADRENERGIC RECEPTOR BY DEER SPECTROSCOPY. Nina Kubatova , Thomas Schmidt, G. Marius Clore 1667-Plat 8:45 am UNRAVELLING BCL-2 PROTEINS´MEMBRANE-MEDIATED FUNCTIONING IN MITOCHONDRIAL APOPTOSIS. Tamas Milan Nagy, Sophie Ayscough, Jörgen Åden , Tobias Sparrman, Hanna Wacklin-Knecht, Luke A. Clifton, Gerhard Grobner 1668-Plat 9:00 am CRYO-EM STRUCTURE OF SYNAPTIC VESICLE PROTEIN 2B. Matthew F. Martin , Anshumali Mittal, Jonathan Coleman 1669-Plat 9:15 am THE SUBSTRATE AND INHIBITOR BINDING MECHANISM OF POLYSPE CIFIC TRANSPORTER OAT1 REVEALED BY HIGH-RESOLUTION CRYO-EM. Tongyi Dou , Tengfei Lian, Shi Shu, Yi He, Jiansen Jiang 1670-Plat 9:30 am DETERMINING NATIVE-LIKE MEMBRANE PROTEIN STRUCTURES FROM CELL MEMBRANE-DERIVED VESICLES. Xiao Tao, Chen Zhao , Roderick MacKinnon 1671-Plat 9:45 am PREFERRED PROTEIN BINDING INTERACTIONS AT THE LIPID BIND ING SITE OF THE ENDOPLASMIC RETICULUM MEMBRANE PROTEIN COMPLEX (EMC). Martin Kulke , Carolin Klose, Kevin Meighen-Berger, Matthias Feige, Martin Zacharias 1672-FlashTalk 10:00 am Travel Award Winner THINK LIKE A CHANNEL, ACT LIKE A CARRIER. Valeria Kalienkova , Mar tin F. Peter, Jan Rheinberger, Cristina Paulino 1673-FlashTalk 10:05 am Travel Award Winner STRUCTURAL STUDIES OF CONNEXIN 32 GAP JUNCTION CHANNELS BY CRYO-EM. Ananth Prasad Burada , Jorge E. Contreras, Aravind Penmatsa 1674-FlashTalk 10:10 am IN SITU STRUCTURE AND MODEL OF THE NUCLEAR BASKET. Joshua Hutchings , Digvijay Singh, Farhaz Shaikh, Sergey Suslov, Elizabeth Villa Platform Protein Stability, Folding, and Chaperones 8:15 am - 10:15 am, Room 201AB Co-Chairs Ekaterina Nestorovich, Catholic University of america, USA Matthias Schneider, University of Cambridge, United Kingdom 1675-Plat 8:15 am BETA-BARREL CHANNEL’S RESPONSE TO HIGH ELECTRIC FIELDS: FUNCTIONAL GATING OR REVERSIBLE DENATURATION? Ekaterina M. Nestorovich , Sergey M. Bezrukov

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