BPS2024 Full Program & Abstracts

1739-FlashTalk 12:30 pm ASSEMBLED STRUCTURES AND MECHANICAL IMPACTS OF EXTRACELLU LAR MATRIX PROTEIN COMPLEXES ON BIOMEMBRANES. Minh D. Phan , Sanjana Sureshbabu, Surabhi Singh, Sushil K. Satija, Norman J. Wagner 1740-FlashTalk 12:35 pm Travel Award Winner PTUA AND PTUB ASSEMBLE INTO AN INFLAMMASOME-LIKE OLIGOMER FOR ANTI-PHAGE DEFENSE. Xiaoyuan Yang 1741-FlashTalk 12:40 pm FRET SPECTROMETRY AND MD SIMULATIONS-BASED MODELING RESOLVE THE OLIGOMERIC STRUCTURE OF A G PROTEIN-COUPLED RECEPTOR IN LIVE CELLS. Dammar N. Badu, Michael R. Stoneman , Ga briel Biener, Thomas D. Killeen, Kaleeckal G. Harikumar, Laurence Miller, Valerica Raicu Platform Voltage-Gated K Channels 10:45 am - 12:45 pm, Room 204AB Co-Chairs Leon Islas, The National Autonomous University of Mexico, Mexico Roya Pournejati, University of Washington, USA 1742-Plat 10:45 am SELECTIVE BLOCK OF HUMAN KV1.1 CHANNEL AND ITS EPILEPSY-ASSO CIATED GAIN-OF-FUNCTION MUTATION BY AETX-K PEPTIDE. Punyanuch Sophanpanichkul , Ruiming Zhao, Arwa Qasim, Jordan H. Chill, Steve A. Travel Award Winner CLUSTER FORMATION BETWEEN BK AND CA V 1.3 CHANNELS PRECEDES THEIR INSERTION INTO THE PLASMA MEMBRANE. Roya Pournejati , Claudia M. Moreno, Oscar Vivas 1744-Plat 11:15 am BK CHANNEL VOLTAGE-GATING MECHANISM PROBED BY SINGLE-PARTI CLE CRYO-EM. Gustavo F. Contreras , Ramon Latorre, Eduardo Perozo 1745-Plat 11:30 am PROBING THE IRAG-HCN4 COMPLEX FOR CRITICAL INTERACTING DOMAINS. Lucas M. Blecker , Colin H. Peters, William G. Nichols, John Bankston, Cathy Proenza 1746-Plat 11:45 am A NOVEL ER COMPARTMENT AS A SUBSTRATE FOR HETEROMERIC ION CHANNEL ASSEMBLY. Sudharsan Kannan , William Kasberg, Catherine A. Eichel, Anjon Audhya, Gail A. Robertson 1747-Plat 12:00 pm SHAKER CHANNEL VOLTAGE-SENSOR ACTIVATION IS MODULATED BY PROTONS. Maru Orozco-Contreras, Gisela E. Rangel-Yescas, Ariela Vergara-Jaque, Leon D. Islas 1748-Plat 12:15 pm SEX DIFFERENCES IN ATRIAL ELECTROPHYSIOLOGY: I K1 IS A MAJOR FAC TOR THAT IS MODULATED BY SEX HORMONES. Lucilla Giammarino , Lluis Matas, Nicolo’ Alerni, Saranda Nimani, Miriam Barbieri, Sahej Bains, Ruben Jose Lopez Dicuru, Julien Louradour, András Horváth, Thomas Hof, Ange Maguy, Katja E. Odening 1749-FlashTalk 12:30 pm Travel Award Winner CHOLESTEROL BINDING TO THE ALPHA SUBUNIT OF LARGE CONDUC TANCE, CALCIUM- AND VOLTAGE-GATED POTASSIUM CHANNELS. Eliza beth H. Schneider , Sydney M. Hawks, Alex M. Dopico, Anna N. Bukiya 1750-FlashTalk 12:35 pm INVESTIGATING THE REGULATORY MECHANISM GOVERNING SURFACE EXPRESSION OF THE SHAKER POTASSIUM CHANNEL. Zerghona Shafia , Rikard Blunck Goldstein 1743-Plat 11:00 am

1751-FlashTalk 12:40 pm ROLE OF K V 7 MUTATIONS IN A NOVEL MECHANISM FOR HYPEREXCIT ABILITY. Moses Kamwela , Carlos A. Villalba-Galea

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Platform Muscle II 10:45 am - 12:45 pm, Room 201C

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Co-Chairs Jinghua Ge, Penn State College of Medicine, USA Weikang Ma, BioCAT, USA 1752-Plat 10:45 am EVIDENCE FOR DIRECT REGULATION OF MYOSIN FILAMENTS BY CALCIUM IN INTACT PORCINE MYOCARDIUM. Weikang Ma , Henry M. Gong, Maria Papadaki, Meihua Guo, Yufan Shao, Qi Qi, Ruibo Liu, Jing Zhao, Siyao Jiang, Thomas C. Irving, Jonathan A. Kirk 1753-Plat 11:00 am IN SITU C-ZONE STRUCTURE OF MAVACAMTEN-FREE HUMAN CARDIAC THICK FILAMENTS BY CRYO-ELECTRON TOMOGRAPHY. Kenneth A. Taylor , Liang Chen, Jun Liu, Hosna Rastegarpouyani, Paul M. Janssen, J. Renato D. Pinto 1754-Plat 11:15 am PROBING THE SRX STATE IN CARDIAC MYOFILAMENTS BY SECOND HARMONIC-GENERATION MICROSCOPY. Leonardo Sacconi , Beatrice Scellini, Nicoletta Piroddi, Corrado Poggesi, Cecilia Ferrantini, Riccardo Cicchi, Chiara Tesi 1755-Plat 11:30 am CARDIOMYOPATHY-ASSOCIATED MUTATIONS IN THE CONVERTER DO MAIN OF BETA-CARDIAC MYOSIN DIFFERENTIALLY ALTER FORMATION OF THE SUPER RELAXED STATE AND INTERACTING HEADS MOTIF. Jing hua Ge , Sebastian Duno-Miranda, Skylar M.L. Bodt, David M. Warshaw, Christopher M. Yengo 1756-Plat 11:45 am GRADED CLEAVAGE OF ELASTIC TITIN IN LIVING MOUSE HEARTS REVEALS THE ROLE OF TITIN STIFFNESS FOR CARDIAC CONTRACTIL ITY. Johanna K. Freundt, Andreas Unger, Christine M. Loescher, Richard Holtmeier, Susanne Hille, Oliver J. Müller, Wolfgang A. Linke 1757-Plat 12:00 pm DIFFERENTIAL DISPLACEMENT OF IMMUNOFLUORESCENT MARKERS IN SARCOMERIC TITIN DURING HISTORY DEPENDENT PROPERTIES. Armaan Sekhon , Chris Tiessen, Tim Leonard, Walter Herzog 1758-Plat 12:15 pm INHIBITORY EFFECTS OF THE MIDDLE DOMAINS OF CARDIAC MYOSIN BINDING PROTEIN-C. Angela C. Greenman , Rachel L. Sadler, Samantha P. Harris 1759-FlashTalk 12:30 pm MYOSIN SOLUBILITY AND FOLDING ENHANCE ITS MOBILITY WITHIN CARDIAC MUSCLE SARCOMERES. Colleen M. Kelly, Jody L. Martin, Molly Coseno, Michael J. Previs 1760-FlashTalk 12:35 pm PULSATILE PERMEABILIZED SLOW-TWITCH SKELETAL MUSCLE FIBERS FROM KNOCK-IN MICE CARRYING A SMYBP-C E248K PATHOGENIC VARI ANT: POTENTIAL FOR A MYOFILAMENT PACEMAKER THAT INITIATES MYOGENIC TREMORS. Laurin M. Hanft , Jennifer Mariano, Aikaterini Kontrogianni-Konstantopou, Kerry S. McDonald 1761-FlashTalk 12:40 pm Travel Award Winner MYBPC3 -C.772G>A MUTATION RESULTS IN HAPLOINSUFFICIENCY AND ALTERED MYOSIN CYCLING KINETICS IN A PATIENT INDUCED STEM CELL DERIVED CARDIOMYOCYTE MODEL OF HYPERTROPHIC CARDIOMY -

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