BPS2024 Full Program & Abstracts

2268-Pos Board B417 EVIDENCE FOR DIRECT REGULATION OF MYOSIN FILAMENTS BY CAL CIUM IN INTACT PORCINE MYOCARDIUM. Weikang Ma , Henry M. Gong, Maria Papadaki, Meihua Guo, Yufan Shao, Qi Qi, Ruibo Liu, Jing Zhao, Siyao Jiang, Thomas C. Irving, Jonathan A. Kirk 2269-Pos Board B418 IN SITU C-ZONE STRUCTURE OF MAVACAMTEN-FREE HUMAN CARDIAC THICK FILAMENTS BY CRYO-ELECTRON TOMOGRAPHY. Kenneth A. Taylor , Liang Chen, Jun Liu, Hosna Rastegarpouyani, Paul M. Janssen, J. Renato D. Pinto 2270-Pos Board B419 INHIBITORY EFFECTS OF THE MIDDLE DOMAINS OF CARDIAC MYOSIN BINDING PROTEIN-C. Angela C. Greenman , Rachel L. Sadler, Samantha P. Harris 2271-Pos Board B420 THE CTNI-R145W MUTATION ALLOSTERICALLY ALTERS THE N-CTNI : N CTNC INTERFACE IN THE PRESENCE OF PKA MEDIATED PHOSPHORYLA TION OF CTNI SER23/24. Romi Castillo , Jil C. Tardiff Cell Mechanics, Mechanosensing, and Motility (Boards B421 - B451) 2272-Pos Board B421 KIDNEY MESANGIUM ORGANOTYPIC CULTURE REVEALS CO-STIMU LATORY MECHANO-CHEMICAL INTERPLAY FOR FIBROTIC MANIFESTA TION. Biswajoy Ghosh , Krishna Agarwal 2273-Pos Board B422 FIBROBLAST ACTIVATION AND CONTRACTILITY ON PEG-BASED HY DROGELS. Sara faour , Cyrille Vézy, Stephanie Salesse, Benoit Langlois, Stephane Dedieu, Rodolphe Jaffiol 2274-Pos Board B423 MECHANICAL COMPARISON OF ISOLATED AND LIVING BREAST CANCER CELL NUCLEI. Ellen J. Poertner , Adam Cohen Simonsen, Tobias Jarrett, Anna Mularski, Jesper Nylandsted, Stine Lauritzen, Anne Sofie Busk Board B424 COLLECTIVE FIBROBLAST MECHANICS IN OVARIAN CANCER METASTA SIS. Charlotte R. Pfeifer , Karen H. Hales, Dale B. Hales, Amy E. Shyer, Alan R. Rodrigues 2276-Pos Board B425 SELF-ORGANIZATION OF OVARIAN CANCER ORGANOIDS REVEALED BY 3D IMAGE SEGMENTATION AND PHASE-FIELD MODEL. Toshikaze Chiba , Kotaro Kawamura, Keita Yanagiya, Yutaka Oya, Toshihiro Kawakatsu, Tatsuaki Tsuruyama, Masayuki Imai 2277-Pos Board B426 SUBSTRATE STRESS RELAXATION MEDIATES THE TRANSITION BETWEEN SUB-DIFFUSIVE AND SUPER-DIFFUSIVE MIGRATION. Vivek Sharma , Omkolade Adebowale, Ze Gong, Ovijit Chaudhuri, Vivek B. Shenoy 2278-Pos Board B427 UNVEILING THE IMPACT OF COMPRESSION ON MELANOMA ADAPTA TIONS. Xingjian Zhang , Xin Shi, Dingyao Zhang, Xiangyu Gong, Zhang Wen, Israel Demandel, Junqi Zhang, Alejandro Rossello, Trevor Chan, Michael Mak 2279-Pos Board B428 MATRIX STIFFNESS INDUCED PIEZO-1 ACTIVATION PROMOTES META STATIC POTENTIAL IN THREE-DIMENSIONAL HEAD AND NECK CANCER SPHEROIDS. Maulee Sheth , Manju Sharma, leyla Esfandiari Heitmann 2275-Pos

2280 -Pos Board B429 EFFECT OF THE COMMUNITY SIZE AND SPATIAL ARRANGEMENT OF CARDIOMYOCYTE NETWORK IN REGULATING CELL RESPONSE TO A PRO ARRHYTHMIC COMPOUND. Kazufumi Sakamoto , Suguru Matsumoto, Nanami Abe, Mitsuru Sentoku, Kenji Yasuda 2281-Pos Board B430 RHOKAR SENSOR REVEALS CALCIUM-DEPENDENT ACTIVATION OF RHO-KINASE DURING COLLECTIVE CELL MIGRATION. Allison E. Mancini , Dominic P. Isaacs, Megan A. Rizzo 2282 -Pos Board B431 CELL CROWDING-INDUCED GEOMETRIC CONSTRAINT REGULATES CHROMATIN ORGANIZATIONS. Alexandra G. Bermudez , Zoe Latham, Jimmy Hu, Neil Lin 2283 -Pos Board B432 PULLING AND PUSHING ON THE NUCLEUS: THE ROLE OF VIMENTININ NUCLEAR SHAPE. Maxx Swoger , Daniel Conway, Heidi Hehnly, Alison Patteson 2284 -Pos Board B433 COMPRESSIVE STRESS CHANGES THE BIOPHYSICAL PROPERTIES OF THE NUCLEUS IN AN IN-VITRO MODEL OF PANCREATIC ADENOCARCINO MA. Shivanjali Saxena , Gregory Brittingham, Sarah Keegan, Liam J. Holt 2285-Pos Board B434 VIMENTIN INTERMEDIATE FILAMENTS ENABLE COLLECTIVE CELL MIGRATION THROUGH 3D COLLAGEN MATRIX . Minh Tri Ho Thanh , Tao Zhang, Jennifer Schwarz, Alison Patteson 2286-Pos Board B435 EMERGENT DEPTH-MECHANOSENSING BY EPITHELIAL CLUSTERS. Hong Board B436 EFFECT OF SEQUENTIALLY ALTERING TOPOGRAPHICAL CONSTRAINTS ON MIGRATION AND LOCAL ORDERING OF EPITHELIAL CELLS. Mitsuru Sentoku , Kenji Yasuda 2288 -Pos Board B437 BEHAVIORAL RESPONSE OF SEMITERRESTRIAL CRABS TO MECHANI CAL STIMULATION FOR UNDERSTANDING THEIR DETECTION OF LOCAL PREDATOR/PREY SIGNALS. Latifah Almaghrabi , David Purta, Paula Marques, Pedro Fonseca, Kenneth J. Lohmann, Philip R. LeDuc 2289 -Pos Board B438 UNDERSTANDING THE EFFECTS OF RADIOIMMUNOTHERAPY ON NANOMECHANICAL, VISCOELASTIC PROPERTIES OF LIVE GLIOBLAS TOMA CELLS USING ATOMIC FORCE MICROSCOPY (AFM). Nabila Masud, Nathan Faivre, Xuan Xuan Lee, Andrew E. Ekpenyong, Anwesha Sarkar 2290 -Pos Board B439 COMPRESSION STIFFENING IN ADIPOSE TISSUES. Xuechen Shi , Carmen Flesher, David Merrick, Paul Janmey 2291-Pos Board B440 COLLECTIVE CELL MIGRATION DRIVEN BY MECHANICAL COUPLING. Ab dul Malmi Kakkada 2292 -Pos Board B441 ANALYZING CELLULAR BEHAVIOR TO PREDICT MULTINUCLEATION IN MAMMARY EPITHELIAL CELLS. Maryam Kohram , Celeste M. Nelson 2293 -Pos Board B442 MODELLING CELLULAR INTERACTIONS WITH THE MECHANICAL PROPERTIES OF THE ENVIRONMENT THROUGH A STOCHASTIC VERTEX BASED MODEL OF SINGLE CELL MIGRATION. Elizabeth M. Davis , Max A. Hockenberry, James E. Bear, Timothy C. Elston sheng Yu 2287-Pos

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