BPS2024 Full Program & Abstracts

2320 -Pos Board B469 STRUCTURAL IMPACT OF AUTISM-LINKED MUTATIONS IN NEUROLIGIN AND NEUREXIN COMPLEXES. Akshada S. Pradhan , Isabella Shimabu kuro, Richard J. Lindsay, Sonya M. Hanson 2321-Pos Board B470 THE GAIN-OF-FUNCTION MUTANTS OF THE SLO1 AND SLACK CHANNELS CAUSE EPILEPSY THROUGH DIFFERENT NEURAL CIRCUITS. Jun Gan, Xiao-hui Wang, Dan-Ya Zhong, Fei-Fei Zhang, Xin-Ran ZHuang, Zhong Shan Shen, Qiong-Yao Tang, Zhe Zhang Computational Neuroscience (Boards B471 - B476) 2322 -Pos Board B471 VALIDATION OF REFERENCE SPIKES AS PLASTICITY IN THE TIME DOMAIN FOR SNN TRAINED SUPERVISED. Zeyuan Wang , Luis Cruz 2323 -Pos Board B472 FORMATION OF SYNAPTIC PATHWAYS WITH NEURONAL TRAVELING WAVES. Kendall J. Butler , Luis Cruz 2324 -Pos Board B473 SPINE APPARATUS MODULATES CA 2+ IN SPINES THROUGH SPATIAL LO CALIZATION OF SOURCES AND SINKS. María Hernández Mesa , Guada lupe Garcia, Frederic Hoerndli, Kimberly J. McCabe, Padmini Rangamani 2325-Pos Board B474 REPURPOSING AVAILABLE DRUGS TO TARGET TREM2 IN ALZHEIMER’S DISEASE USING UNBIASED VIRTUAL SCREENING AND EXPERIMENTAL VALIDATION. Rory A. Greer , Hunter B. Dean, Thomas J. Brett, Erik D. Roberson, Yuhua Song 2326-Pos Board B475 INSIGHTS INTO THE SELECTIVE INHIBITION OF AN ALZHEIMER’S DISEASE DRUG CANDIDATE P5 ON CDK5-P25 COMPLEX IN THE PRESENCE OF MUNC18-1 USING UMBRELLA SAMPLING MOLECULAR SIMULA TIONS. Tejaswi Tammareddy , Antonio Cardone, Harish C. Pant, Walid Keyrouz, Ram Sriram, Jeffery B. Klauda 2327-Pos Board B476 Travel Award Winner TARGETING ANTI-AGGREGATION AND ANTI-OXIDATION OF AMYLOID DEPOSITS FOR THERAPEUTIC INTERVENTION OF ALZHEIMER’S USING MACHINE LEARNING ENHANCED MOLECULAR DOCKING. Luthary Y. Se gura , Natalia Santos, Kwan Hon K. Cheng, Donald Sikazwe, Rafael Flores, Vincent Blay Rogers, Miles Mcgibbon Neuroscience: Experimental Approaches and Tools (Boards B477 - B482) 2328 -Pos Board B477 NEAR INFRARED VOLTAGE SENSITIVE DYES BASED ON A NOVEL CHRO MOPHORE. Ping Yan, Corey D. Acker, Srdjan D. Antic, Leslie M. Loew 2329 -Pos Board B478 HOW SEVERAL FACTORS, PLAYING IN CONCERT, INCREASE THE TWO PHOTON FLUORESCENCE RESPONSE OF RED FLUORESCENT PROTEIN SENSORS. Mikhail Drobizhev , Rosana S. Molina, Thomas E. Hughes 2330 -Pos Board B479 MULTI-COLOR SUPER-RESOLUTION IMAGING OF SURFACE AMPAR AND PHOSPHOTAU INSIDE DENDRITIC SPINES IN THICK BRAIN SLICE. Yongjae Lee , Rohit M. Vaidya, Duncan L. Nall, Jiahao Zhang, Donghan Ma, Fang Huang, Shigeki Kiyonaka, Itaru Hamachi, Hee Jung Chung, Paul R. Selvin 2331-Pos Board B480 OBSERVING NANOSCALE ORGANIZATION OF NATIVE, CELL-SURFACE AMPARS IN MOUSE BRAIN SLICES AS A FUNCTION OF BRAIN REGION AND TAUPATHY. Rohit M. Vaidya , Duncan L. Nall, Jiahao Zhang, Yongjae

Lee, Donghan Ma, Fang Huang, Shigeki Kiyonaka, Itaru Hamachi, Hee Jung Chung, Paul R. Selvin 10 2332 -Pos Board B481 INVESTIGATING PROTEIN STRUCTURAL CHANGES ASSOCIATED WITH COGNITIVE DECLINE IN A RODENT MODEL OF AGING USING LIMITED PROTEOLYSIS MASS SPECTROMETRY. Haley E. Tarbox , Audrey Branch, Michela Gallagher, Stephen D. Fried 2333 -Pos Board B482 CO-VET : CORRELATIVE - VOLTAGE IMAGING AND CRYO-ELECTRON TOMOGRAPHY. Mingyu Jung , Gwanho Ko, Seonghoon Kim, Myunghwan Choi, Soung-Hun Roh EPR and NMR: Spectroscopy and Imaging (Boards B483 - B487) 2334 -Pos Board B483 INTERPRETATION OF RAW NMR DATA WITH BAYESIAN NONPARAMET RICS. Ioannis Sgouralis , Kelechi Akwataghibe, Mubark Mebrat, Wade D. Board B484 KINETIC CHARACTERIZATION OF BIOMOLECULAR HYDROGEL DYNAM ICS. Tianyue Dai 2336-Pos Board B485 Travel Award Winner SENSITIVITY ENHANCEMENT IN BIOMOLECULAR NMR:CHARACTERIZATION AND OPTIMIZATION OF LC-PHOTO-CIDNP FOR THE STRUCTURAL ANALYSIS OF PROTEINS IN SOLUTION. Ummay Mahfuza Shapla , Silvia Cavagnero 2337-Pos Board B486 UNRAVELING THE BINDING MODES OF THE FIP200 CLAW DOMAIN. Da vid A. Nyenhuis , William M. Rosencrans, Daniel L. Morris, Richard Youle, Nico Tjandra 2338 -Pos Board B487 CONFINEMENT AND INTERFACES MAKE WATER WEIRD: OBSERVA TIONS WITH ULTRA-SENSITIVE MAGNETIC RESONANCE CROSS-RELAX ATION. John M. Franck In Situ Cryo-EM: Methods and Applications (Boards B488 - B499) 2339 -Pos Board B488 VISUALIZING MITOCHONDRIAL BUDDING IN INTACT BS-C-1 CELLS BY IN-SITU CRYO-ELECTRON TOMOGRAPHY. Judy Z. Hu, Lijun Qiao, Xianhai Zhao, Chang-Jun Liu, Guobin Hu 2340 -Pos Board B489 MULTIMODAL MICRO- AND NANOPLASTICS ANALYTICS IN PLANT MA TRIX. Joerg Wissler , Philipp Haefner, Hans-Achim Reimann 2341-Pos Board B490 TIME-RESOLVED CRYOGENIC ELECTRON TOMOGRAPHY WITH MIX-AND SPRAY MICROFLUIDIC DEVICES. Joseph Yoniles 2342 -Pos Board B491 ENVIRONMENTAL BIOSENSORS FOR CRYOGENIC CORRELATIVE LIGHT AND ELECTRON MICROSCOPY. Christopher A. Azaldegui , Yue Rui, An thony Vecchiarelli, José Dinneny, Julie Biteen, Peter D. Dahlberg 2343 -Pos Board B492 NOVEL SARS-COV-2 VLP SYSTEM AND STRUCTURAL CHARACTERIZATION BY CRYOGENIC ELECTRON TOMOGRAPHY REVEALS ORF3A AND ORF7A ACCESSORY PROTEINS AS CRITICAL FOR ASSEMBLY. Juliana Abramovich Van Horn 2335-Pos

T U

E S

D A Y

136