BPS2024 Full Program & Abstracts

New Council Meeting 8:00 am - 11:30 am, Room 104AB Poster Viewing 8:00 am - 3:00 pm, Exhibit Hall AB Symposium Genome Organization 8:15 am - 10:15 am, Ballroom A

Platform Ion Channels, Pharmacology, and Disease 8:15 am - 10:15 am, Room 103AB

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Co-Chairs Yu Chen, University of British Columbia, Canada Crina Nimigean, Weill Cornell Medical College, USA 2480-Plat 8:15 am

PROPOFOL RESCUES HCN1 EPILEPSY MUTANTS AND REVEALS NON-CA NONICAL VOLTAGE-DEPENDENT GATING IN HCN CHANNELS. Elizabeth D. Kim , Xiaoan Wu, Sangyun Lee, Gareth R. Tibbs, Kevin P. Cunningham, Marta E. Perez, Peter A. Goldstein, Alessio Accardi, Peter H. Larsson, Crina M. Nimigean 2481-Plat 8:30 am CC6 IS A SPECIFIC ENHANCER OF THE I KS CHANNEL IN THE HEART. Lu Zhao , Xianjin Xu, Virgis Valiunas, Jingyi Shi, Junyuan Gao, Mengqi Gu, Lu Han, Ira.S Cohen, Xiaoqin Zou, Jianmin Cui 2482-Plat 8:45 am ENHANCED NA V 1.5 ( SCN5A ) ACTIVATION IN CPVT-LIKE ARRHYTHMIA. Serena Pozzi , Pia Dahlberg, Linda Bulmer, Amaia Jauregi Miguel, Mi chelle Nilsson, Anders Nygren, Anders Gummesson, Antonios Pantazis 2483-Plat 9:00 am STRUCTURAL BASIS FOR CA V Α 2 Δ-GABAPENTIN BINDING . Abhisek Mondal , Zhou Chen, Daniel L. Minor 2484-Plat 9:15 am CRYO-EM ANALYSIS OF THE MALIGNANT HYPERTHERMIA-CAUSING T4826I MUTANT OF RYANODINE RECEPTOR 1 AND ITS INTERPLAY WITH PHARMACOLOGICAL AGENTS. Yu S. Chen , Maricela García-Castañeda, Paul D. Allen, Filip Van Petegem 2485-Plat 9:30 am Travel Award Winner ROLE OF THE PROTON-ACTIVATED CHLORIDE (PAC) CHANNEL IN SARS COV-2 VIRAL ENTRY. Nicholas R.M. Koylass , Henry Yi Cheng, Kevin Chen, Zhaozhu Qiu 2486-Plat 9:45 am NOVEL LOSS-OF-FUNCTION MUTATIONS IN K V 7.2, AND THEIR POSSIBLE INVOLVEMENT IN EPILEPSY. Tibor Szanto , Gyorgy Panyi, Istvan Balogh 2487-FlashTalk 10:00 am CHLORIDE INTRACELLULAR CHANNELS (CLICS) REGULATE SPERMATO GENESIS. Veronica Loyo-Celis , Shridhar K. Sanghvi, Satish Raut, Devasena Ponnalagu, Harpreet Singh 2488-FlashTalk 10:05 am NICLOSAMIDE POTENTIATES TMEM16A AND INDUCES VASOCON STRICTION. Pengfei Liang , Yui Chun S. Wan, Kuai Yu, H. Criss Hartzell, Huanghe Yang 2489-FlashTalk 10:10 am THE MOLECULAR BASIS FOR KCNQ3 ISOFORM-SELECTIVE ACTIVITY OF CARNOSIC ACID. Rían W. Manville , Guilian Tian, Derk Hogenkamp, Kevin T. Beier, Geoffrey W. Abbott

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Chair Ana Pombo, Max Delbruck Center for Molecular Medicine, Germany No Abstract 8:15 am TALK TITLE TBD. Clodagh O’Shea No Abstract 8:40 am BEND IT LIKE BECKHAM- THE ROLE OF ELASTICITY IN CHROMATIN DYNAMICS. Yamini Dalal No Abstract 9:05 am CHROMOSOMES AS GENOME COMMUNICATION AND MEMORY MA CHINES. Leonid Mirny 2474-SympSelect 9:30 am MOLECULAR KINETICS OF TRANSCRIPTION REGULATION DURING EM BRYONIC DEVELOPMENT. Mustafa Mir 2475-Symp 9:50 am SPECIALISATION OF 3D GENOME STRUCTURE IN DIFFERENT CELL TYPES AND STATES. Ana Pombo Symposium Emerging Concepts in Microtubule Function 8:15 am - 10:15 am, Ballroom B Chair Sabine Petry, Princeton University, USA 2476-Symp 8:15 am METABOLIC REGULATION BY ENZYME POLYMERIZATION. Justin M. Koll man , Eric M. Lynch, Kelli L. Hvorecny, Audrey O’Neill, John Calise 2477-Symp 8:40 am MICROTUBULE CARTOGRAPHY: HOW MICROTUBULE-ASSOCIATED PRO TEINS SHAPE THE CELLULAR LANDSCAPE. Kassandra Ori-McKenney , Yusheng Shen, Regina L. Agulto, Tracy Tan 2478-Symp 9:05 am ASSEMBLING THE CELL’S ANTENNA WITH MICROTUBULE-BASED MO LECULAR MOTORS. Katerina Toropova 2479-SympSelect 9:30 am KINETOCHORES ARE INTRINSICALLY SENSITIVE TO MICROTUBULE PO LARITY. Charles L. Asbury , Joshua D. Larson, Natalie A. Heitkamp, Lucas E. Murray, Andrew R. Popchock, Sue Biggins No Abstract 9:50 am HOW TO MAKE MICROTUBULES AND BUILD THE CYTOSKELETON. Sabine Petry

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