BPS2024 Full Program & Abstracts

Platform Condensates: Physical Properties and Modeling II 8:15 am - 10:15 am, Room 113AB Co-Chairs Jerelle Joseph, Princeton University, USA Anisha Shakya, Institute for Basic Science, South Korea 2490-Plat 8:15 am FRUSTRATION ENABLES THE LIQUID-LIQUID PHASE SEPARATION OF NONSPECIFICALLY INTERACTING COILED-COIL PROTEINS. Dominique Ramirez , Loren Hough, Michael Shirts 2491-Plat 8:30 am AN ACCURATE MODEL FOR PROBING PROTEIN PHASE SEPARATION UNDER HEAT STRESS. Ananya Chakravarti , Jerelle A. Joseph 2492-Plat 8:45 am Travel Award Winner UNCOVERING THE MOLECULAR LANGUAGE OF PROTEIN LIQUID-LIQUID PHASE SEPARATION. Shiv Rekhi , Cristobal Garcia, Mayur Barai, Azamat Rizuan, Benjamin S. Schuster, Kristi L. Kiick, Jeetain Mittal 2493-Plat 9:00 am PROTEIN UNFOLDING THERMODYNAMICS PREDICT MULTICOMPONENT PHASE BEHAVIOR. Anisha Shakya , Neha Rana, Rukhillo Kodirov, John King 2494-Plat 9:15 am EXPLORING THE SOLUBILITY PRODUCT CONCEPT FOR DESCRIBING THE FORMATION OF BIOMOLECULAR CONDENSATES BY COMPARING IN VITRO AND IN SILICO SYSTEMS. Jonathon A. Ditlev , Zeynep Baltaci, Aniruddha Chattaraj, Bruce J. Mayer, Leslie M. Loew 2495-Plat 9:30 am CROWDING ACCELERATES MOLECULAR AGING IN PROTEIN CONDEN SATES. Mateusz Brzezinski, Pablo Argudo, Jasper Michels, Sapun H. Parekh 2496-Plat 9:45 am EPIGENETIC MARKS UNIQUELY TUNE MATERIAL PROPERTIES OF HP1Α CONDENSATES. Priyasha Deshpande 2497-FlashTalk 10:00 am DIFFERENTIAL ELECTROSTATIC EFFECTS OF SEQUENCE-LOCAL AND NONLOCAL CHARGE PATTERNS ON PHASE SEPARATION AND CON FORMATIONAL DIMENSIONS OF POLYAMPHOLYTES AS MODELS FOR INTRINSICALLY DISORDERED PROTEINS. Tanmoy Pal, Suman Das, Jonas Wessén, Hue Sun Chan 2498-FlashTalk 10:05 am PROBING THE MATERIAL PROPERTIES OF NUCLEOLI USING MICROPI PETTE ASPIRATION. Holly Cheng , Huan Wang, Zheng Shi, Clifford P. Brangwynne 2499-FlashTalk 10:10 am QUANTIFICATION AND REGULATION OF THE MATERIAL PROPERTIES OF SYNAPSIN CONDENSATES IN VITRO AND IN LIVE CELLS. Huan Wang , Christian Hoffmann, James Roggeveen, Xiao Su, Jordan Elliott, Johannes V. Tromm, Zhiping Pang, Howard A. Stone, Jean Baum, Dragomir Milova novic, Zheng Shi

Platform Protein Structure and Conformation III 8:15 am - 10:15 am, Room 201AB

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Co-Chairs Sheena Vasquez, Stanford University, USA Brian Weiser, Rowan University, USA 2500-Plat 8:15 am

Travel Award Winner STRUCTURAL INVESTIGATIONS OF THE CYTOSOLIC IRON-SULFUR CLUS TER ASSEMBLY PATHWAY LATE ACTING PROTEINS. Sheena Vasquez , Melissa M. Marquez, Anastasiya Buzuk, Catherine L. Drennan, Deborah 8:30 am STRUCTURAL CHARACTERIZATION OF MALLARD SECRETORY IMMUNO GLOBULIN A. Rebecca M. Schneider , Qianqiao Liu, Beth M. Stadtmuel ler 2502-Plat 8:45 am NATIVE ENTANGLEMENT MISFOLDING CAN CAUSE A LOSS-OF-FUNC TION IN ESSENTIAL PROTEINS. Ian M. Sitarik , Edward P. O’Brien 2503-Plat 9:00 am Travel Award Winner PLEIOTROPHIN’S INTERACTION WITH Α M -I DOMAIN OF INTEGRIN Α M Β 2 IS ACTIVATION STATE DEPENDENT. Hoa Nguyen , Xu Wang, Tatiana Ugarova, Nataly Podolnikova 2504-Plat 9:15 am CRYO-EM ASSISTS IN CAPTURING ALL THE INTERMEDIATE STEPS OF PORE FORMATION BY BACTERIAL PORE-FORMING TOXINS ON THE PLASMA MEMBRANE. Somnath Dutta , Arnab Chaterjee, Anupam Roy, Prithiv Kishore, Bapan Mondal, Partho P. Das 2505-Plat 9:30 am DESIGNER MOLECULES OF THE SYNAPTIC ORGANIZER MDGA1 REVEAL 3D CONFORMATIONAL CONTROL OF BIOLOGICAL FUNCTION. Hubert Lee 2506-Plat 9:45 am DIMERIZATION AFFECTS THE DEACYLASE ACTIVITIES OF HUMAN SIR TUIN-2 (SIRT2). Jie Yang , Nathan I. Nicely, Brian P. Weiser 2507-FlashTalk 10:00 am DISSECTING THE CONFORMATIONAL ENSEMBLE OF LC3B STATES IN MEMBRANE TETHERING AND RECEPTOR BINDING. Deepanshi Gahlot , Lipi Thukral 2508-FlashTalk 10:05 am Travel Award Winner INVESTIGATING THE EFFECTS OF CTD MUTATIONS AS PLASMA MEM BRANE ASSOCIATION OF THE MARBURG VIRUS PROTEIN VP40. Tej K. Sharma , Michael Cioffi, Bernard S. Gerstman, Robert V. Stahelin, Prem P. Chapagain 2509-FlashTalk 10:10 am UNDERSTANDING ENGULFMENT OF ANTIFREEZE PROTEINS BY ICE. Yusheng Cai , Aniket Thosar, Sean Marks, Zachariah Vicars, Jeongmoon Choi, Akash Pallath, Amish Patel L. Perlstein 2501-Plat

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