BPS2024 Full Program & Abstracts

2712-Pos Board B104 FROM CLOSED TO OPEN: EXPLORING THE CONFORMATIONAL CHANGES AND INFLUENCE OF A BIOCHEMICAL INHIBITOR ON EFFLUX PUMP ACRAB-TOLC. Katie M. Kuo , Yui Tik Pang, Diane L. Lynch, James C. Gum bart, Helen I. Zgurskaya Protein Aggregates (Boards B105 - B131) 2713-Pos Board B105 DEVELOPING RNA THERAPEUTICS FOR TDP-43 PROTEINOPATHY IN ALS/ FTD. Katie Copley , Ashleigh Smirnov, Leland Mayne, Yuanhang Wang, Ben E. Black, James Shorter 2714-Pos Board B106 DETECTION OF MISFOLDED PROTEINS IN ALS PATIENTS TISSUE SAMPLE USING RT-QUIC. Justin Mielke 2715-Pos Board B107 THE INHIBITION OF IAPP AGGREGATION BY INSULIN IS MODULATED BY PH AND ZINC. Samuel D. McCalpin , Lucie P. Khemtemourian, Saba Suladze, Magdalena Ivanova, Bernd Reif, Ayyalusamy Ramamoorthy 2716-Pos Board B108 ANTI-AMYLOIDOGENIC EFFECTS OF NEUROKININ A AND ITS ANALOG NKAW ON AMYLOID-BETA 1-42 AGGREGATION IN ALZHEIMER’S DIS EASE. Mohsen Habibnia , Èric Catalina-Hernández, David Masnou-Sán chez, Mario López-Martín, Alex Perálvarez-Marín 2717-Pos Board B109 UNRAVELING HEPARIN’S IMPACT ON AMYLOID-Β AGGREGATION: MECHANISMS AND CONTRASTS WITH CHITOSAN. Suhas Gotla , Silvina Board B110 INTERACTION OF AMYLOID BETA WITH PHOSPHOLIPID BILAYER CHAR ACTERIZED BY AFM. Ruan van Deventer , Yuri L. Lyubchenko 2719-Pos Board B111 DIFFERENTIATION OF R5L AND WILD TYPE TAU AGGREGATION. Kayleigh Mason , Zachary J. Donhauser 2720-Pos Board B112 SINGLE-MOLECULE FLUORESCENCE SPECTROSCOPY OF AMYLOID-BETA AGGREGATION. Hoi Sung Chung , Fanjie Meng, Jae-Yeol Kim, Irina V. Gopich 2721-Pos Board B113 TYROSINE FLUORESCENCE AS AN INTRINSIC PROBE FOR PROTEIN AG GREGATION. Suren A. Tatulian 2722-Pos Board B114 STRUCTURAL BASIS OF POLYANION-INDUCED TAU AMYLOID FORMA TION. Dmitry Malyshka, Austin M. Allen, Bryce A. Guidry, Jeff Kuret 2723-Pos Board B115 EFFECTIVE REGULATION OF PROTEIN AGGREGATION AND DISAGGREGA TION. Mily Bhattacharya , Anjali Giri, Deepika Singla, Jaspreet Kaur 2724-Pos Board B116 ANALYSIS OF THE GROWTH OF SICKLE HEMOGLOBIN FIBERS OBSERVED BY DIC MICROSCOPY. M. T. Levitt , Frank A. Ferrone 2725-Pos Board B117 USING LINEAR DICHROISM TO MEASURE THE PARTICIPATION OF FETAL HEMOGLOBIN IN SICKLE HEMOGLOBIN POLYMERIZATION. Mark K. Fugate , Kimberly C. Grasty, Patrick J. Loll, Frank A. Ferrone Matysiak 2718-Pos

2726-Pos Board B118 THE ROLE OF SHEAR RATES ON AMYLOID FORMATION FROM BIOFILM PEPTIDES PHENOL SOLUBLE MODULINS. Runyao Zhu , Trevor Stone Jr., Yichun Wang 2727-Pos Board B119 RELATING GD-CRYSTALLIN WT AND W42R MONOMER CONFORMA TIONS TO TOPOLOGICAL PROPERTIES OF THEIR UNSTRUCTURED AG GREGATES. Elizabeth M. Diessner , J. Alfredo Freites, Douglas J. Tobias, Carter T. Butts 2728-Pos Board B120 POLYPHENOL BASED MODULATION OF STRUCTURE AND TOXICITY OF HUNTINGTIN PROTEIN AGGREGATES. Greeshama Jain , Marina Trom betta Lima, Irina Matlahov, Amalia Dolga, Patrick C. van der Wel 2729-Pos Board B121 Travel Award Winner THE THERMODYNAMIC STABILITY AND MISFOLDING OF S100A12. Karly B. Serrano , Rekha Pattanayek, Velia Garcia, Nicole Fana Brito, Jennifer Gaddy, Steven Damo 2730-Pos Board B122 CHARACTERIZING AΒ 16-22 AGGREGATION PATHWAYS THROUGH MOLECU LAR DYNAMICS SIMULATIONS. Laura I. Gil Pineda , Kelsie King, Justin A. Lemkul, Anne M. Brown 2731-Pos Board B123 AMYLOID FIBRIL GROWTH IN A HETEROGENEOUS SOLUTION. Ruoyao Zhang , Mikko P. Haataja 2732-Pos Board B124 CHARACTERIZING OLIGOMERIC AMYLOID- Β 42 AND POPC INTERACTIONS THROUGH MOLECULAR DYNAMICS: A COMPUTATIONAL APPROACH FOR UNDERSTANDING ALZHEIMER’S DISEASE. Emma M. Cleveland , Al lison Pennington, Kelsie M. King, Anne M. Brown 2733-Pos Board B125 EFFECT OF POLAR/NON-POLAR SEQUENCE PATTERN ON PEPTIDE AG GREGATION IN HYDROPHOBIC AND HYDROPHILIC SOLVENTS. Siwaporn Sungted , Warin Rangubpit, Cristiano Dias, Jirasak Wong-Ekkabut 2734-Pos Board B126 FAMILIAL AND SPORADIC ALZHEIMER’S DISEASE-RELATED AMYLOID BETA 42 FIBRILS HAVE DISTINCT FIBRIL GROWTH BEHAVIORS. Gangtong Huang , Feng Ding 2735-Pos Board B127 COLLAGEN-AMYLIN CROSSTALK DRIVES THE PROGRESSION OF TYPE 2 DIABETES. MD Asrafuddoza Hazari , Ashutosh Kumar, Shamik Sen 2736-Pos Board B128 EXPLORING MEMBRANE DAMAGE MECHANISMS OF HETEROGENEOUS TAU AND AMYLIN OLIGOMERS IN ALZHEIMER’S USING MD SIMULA TIONS. Kwan Hon K. Cheng , Natalia Santos, Luthary Segura 2737-Pos Board B129 POST-TRANSLATIONAL MODIFICATION SITES ARE PRESENT IN HYDRO PHILIC CAVITIES OF ALPHA-SYNUCLEIN, TAU, FUS AND TDP-43 FIBRILS: A MOLECULAR DYNAMICS STUDY. Noah Nathan Kochen , Darren Seaney, Vivek Vasandani, Marguerite G. Murray, Anthony R. Braun, Jonathan N. Sachs 2738-Pos Board B130 NOVEL METHODS TO STUDY AMYLOID OLIGOMERS. Lei Ortigosa Pas cual , Ewa A. Andrzejewska, Tinna Pálmadóttir, Tuomas P. Knowles, Sara Linse

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