BPS2024 Full Program & Abstracts

2923 -Pos Board B315 SELF-SUPERVISED DEEP LEARNING UNCOVERS THE SEMANTIC LANDSCAPE OF DRUG-INDUCED LATENT MITOCHONDRIAL PHENO TYPES. Zichen Wang 2924 -Pos Board B316 FMRP GRANULES DRIVE MITOCHONDRIAL FISSION VIA LOCAL TRANSLA TION IN NEURONS. Adam Fenton , Ruchao Peng, Charles Bond, Siewert Hugelier, Melike Lakadamyali, Yi-Wei Chang, Erika Holzbaur, Thomas Jongens 2925-Pos Board B317 CRYO-ELECTRON MICROSCOPY STUDIES REVEAL THE INACTIVATION MECHANISM OF ATP SYNTHASE LEAK CHANNEL AND ITS CONTRIBU TION TO MITOCHONDRIAL PERMEABILITY TRANSITION. Amrendra Kumar , Juliana da Fonseca Rezende e Mello, Yangyu Wu, Daniel Morris, Nelli Mnatsakanyan 2926-Pos Board B318 CHANNEL CONFORMATIONAL PLASTICITY OF MITOCHONDRIAL VDAC2 CONTROLS ITS INTERACTION KINETICS WITH CYTOSOLIC PROTEINS. Wil liam M. Rosencrans, Tsyr-Yan Yu, Motahareh Ghahari Larimi, Radhakrish nan Mahalakshmi, Sergey M. Bezrukov, Tatiana K.R. Rostovtseva Voltage-Gated K Channels II (Boards B319 - B341) 2927-Pos Board B319 INHIBITION OF HCN1 BY NORQUETIAPINE AN ACTIVE METABOLITE OF THE ATYPICAL ANTI-PSYCHOTIC DRUG QUETIAPINE. Amelie Jean Jacques , Nazzareno D’Avanzo 2928 -Pos Board B320 GLOBAL FIT OF KCNH1 LIGANDS UNCOVERS BINDING POCKETS IN MUL TIPLE DOMAINS. Kyle C. Kihn , Tinatin I. Brelidze, Jeffery B. Klauda 2929 -Pos Board B321 GAIN-OF-FUNCTION KCNMA1 CHANNELOPATHY VARIANT N999S INCREASES BK CURRENT UNDER CA V 1.2 ACTIVATION. Ria L. Dinsdale , Andrea Meredith 2930 -Pos Board B322 DISEASE RELEVANT MUTATIONS IN KV2.2 HAS DRASTIC EFFECTS ON INACTIVATION PROPERTIES OF THE CHANNEL. Shreyas Bhat , Deniz Özaydın, Justine Rousseau, Phillipe Campeau, Rikard Blunck 2931-Pos Board B323 LONG QT MUTATIONS IMPACT INTERMEDIATE STATES OF THE VOLTAGE SENSOR IN HUMAN ERG CHANNEL. Gucan (Gabriel) Dai , Lucas J. Hand lin, Erin N. Lessie, Natalie L. Macchi 2932 -Pos Board B324 INVESTIGATING K V 7.4 VOLTAGE SENSOR MOVEMENT WITH PULSED VOLTAGE-CLAMP FLUOROMETRY. Mario Nappi, Damon J.A. Frampton, Kaiqian Wang, Francesco Miceli , Sara I. Liin, Antonios Pantazis, Maurizio Taglialatela 2933 -Pos Board B325 THE PHYSICO-CHEMICAL NATURE OF FILTER GATING IN K + CHANNELS. Ol iver Rauh, Noel Tewes, Beatrice Kubitzki, Gerhard Thiel 2934 -Pos Board B326 THE N-TERMINAL PAS DOMAIN STAYS GLOBALLY ATTACHED TO HERG CHANNELS DURING GATING. Matt C. Trudeau 2935-Pos Board B327 NS1619 ACTIVATES THE BK CHANNEL BY STABILIZING S6 HELIX AND STRENGTHEN ELECTROMECHANICAL COUPLING. Naileth Gonzalez Sanabria , Gustavo F. Contreras, Yorley Duarte, Danilo González, Eduardo Perozo, Ramon Latorre

2936-Pos Board B328 KEY ELEMENTARY TRANSITIONS UNDERLYING POLYMODAL ALLOSTERIC REGULATION OF BK CHANNEL GATING. Gopal Kallure , Kamalendu Pal, Sandipan Chowdhury 2937-Pos Board B329 CHANNELOME: A COMPREHENSIVE RESOURCE FOR VOLTAGE-GATED ION CHANNEL KINETICS. Rajnish Ranjan , Emmanuelle Logette, Stijn V. Dorp, Hervé A. Kalaimaken, Mirjia Herzog, Magali S.E. Joffraud, Enrico Scantamburlo, Katherine G. Johnston, Adrien Journe, Henry Markram 2938 -Pos Board B330 STRUCTURAL BASIS FOR REGULATION OF KV2.1 BY PIP2. Xiaofeng Tan , Ana I. Fernández-Mariño, Chanhyung Bae, Kenton Swartz 2939 -Pos Board B331 CHARYBDOTOXIN BINDING TO SHAKER POTASSIUM CHANNELS, A CASE OF LOCK AND KEY EQUILIBRIUM: VOLTAGE, EXTERNAL POTASSIUM AND TEMPERATURE DEPENDENCE. Nieves Navarro, Francisca Salas, Horacio Poblete, David Naranjo 2940 -Pos Board B332 GAIN-OF-FUNCTION EFFECTS BY PORE VARIANTS IN K V 7.2 AND K V 7.3 POTASSIUM CHANNEL SUBUNITS CAUSING DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY. Maurizio Taglialatela , Simone Nappi, Giulio Alberini, Luca Maragliano, Agnese Roscioni, Alessandro Berselli, Vincenzo Barrese, Ingrid Scheffer, Fabio Benfenati, Francesco Miceli 2941-Pos Board B333 A MOLECULAR DISSECTION OF BK CHANNELOPATHIES IN NEUROLOGI CAL DISORDERS. Guohui Zhang , Jingyi Shi, Mohamad Mikati, Huanghe Yang, Jianmin Cui 2942 -Pos Board B334 NON-CONSERVED RESIDUES IN A SILENT KV SUBUNIT AND THE FUNC TION OF HETEROMERIC KV CHANNELS. Luiz Moreira Junior, Joao L. Carvalho-de-Souza 2943 -Pos Board B335 EFFECTS OF SMALL MOLECULES ON NEURODEVELOPMENTAL DISOR DER-ASSOCIATED KV7.2/3 MUTATIONS. Rene Barro-Soria 2944 -Pos Board B336 INVESTIGATING THE REGULATORY MECHANISM GOVERNING SURFACE EXPRESSION OF THE SHAKER POTASSIUM CHANNEL. Zerghona Shafia , Rikard Blunck 2945-Pos Board B337 Travel Award Winner CHOLESTEROL BINDING TO THE ALPHA SUBUNIT OF LARGE CONDUC TANCE, CALCIUM- AND VOLTAGE-GATED POTASSIUM CHANNELS. Eliza beth H. Schneider , Sydney M. Hawks, Alex M. Dopico, Anna N. Bukiya 2946-Pos Board B338 ROLE OF K V 7 MUTATIONS IN A NOVEL MECHANISM FOR HYPEREXCIT ABILITY. Moses Kamwela , Carlos A. Villalba-Galea 2947-Pos Board B339 SEX DIFFERENCES IN ATRIAL ELECTROPHYSIOLOGY: I K1 IS A MAJOR FAC TOR THAT IS MODULATED BY SEX HORMONES. Lucilla Giammarino , Lluis Matas, Nicolo’ Alerni, Saranda Nimani, Miriam Barbieri, Sahej Bains, Ruben Jose Lopez Dicuru, Julien Louradour, András Horváth, Thomas Hof, Ange Maguy, Katja E. Odening 2948 -Pos Board B340 SELECTIVE BLOCK OF HUMAN KV1.1 CHANNEL AND ITS EPILEPSY-ASSO CIATED GAIN-OF-FUNCTION MUTATION BY AETX-K PEPTIDE. Punyanuch Sophanpanichkul , Ruiming Zhao, Arwa Qasim, Jordan H. Chill, Steve A. Goldstein

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