BPS2024 Full Program & Abstracts

2974-Pos Travel Award Winner MOLECULAR SIMULATIONS OF STATE-SPECIFIC INTERACTIONS WITH CARDIAC ION CHANNELS FOR IN SILICO PREDICTION OF DRUG-INDUCED ARRHYTHMOGENESIS. Kyle C. Rouen , Khoa Ngo, Adriana Hernández González, Colleen E. Clancy, Vladimir Yarov-Yarovoy, Surl-Hee Ahn, Alex ander D. MacKerell, Igor V. Vorobyov 2975-Pos Board B367 A GENETICALLY ENCODED ACTUATOR SELECTIVELY BOOSTS L-TYPE CAL CIUM CHANNELS IN DIVERSE PHYSIOLOGICAL SETTINGS. Pedro J. del Rivero Morfin , Diego Scala-Chavez, Srinidhi Jayaraman, Lin Yang, Audrey Lauris Kochiss, Henry M. Colecraft, X. Shawn Liu, Steven O. Marx, Anjali M. Rajadhyaksha, Manu Ben-Johny 2976-Pos Board B368 DEFECTIVE INTERACTION OF LQTS-ASSOCIATED CAM E105A MUTANT WITH A RYANODINE RECEPTOR 2 CAM-BINDING POCKET. Michail Nomikos , Angelos Thanasoulas, Maria Theodoridou, Laila Barrak, Emna Riguene, Tamader Alyaarabi, Mohamed A. Elrayess, F. Anthony Lai 2977-Pos Board B369 PROPOFOL BINDING SITES ON RYANODINE RECEPTOR 1. Thomas T. Jo seph , Weiming Bu, Omid Haji-Ghassemi, Kellie Woll, Grace H. Brannigan, Filip Van Petegem, Roderic G. Eckenhoff 2978-Pos Board B370 CRYO-EM REVEALS BINDING OF RYANODINE RECEPTORS TO DRUGS THAT ARE ASSOCIATED WITH MUSCLE WEAKNESS. Steven Molinarolo , Carmen R. Valdivia, Hector H. Valdivia, Filip Van Petegem 2979-Pos Board B371 THE RYR2-SELECTIVE INHIBITOR ENT-VERTICILIDE PREVENTS VENTRICU LAR ARRHYTHMIA WITH CHRONIC AND ORAL DOSING. Paxton Ritschel, Daniel J. Blackwell, Madelaine P. Thorpe, Jeffrey N. Johnston, Scott W. Akers, Bjorn C. Knollmann 2980 -Pos Board B372 HTS AND LYSOPATCH? NEW FRONTIERS OF ORGANELLAR ELECTROPHYS IOLOGY. Manuel Paina, Katja Blasi, Elena Sirtori, Fernanda Ricci, Anna Mondini, Jean-Francois Rolland 2981-Pos Board B373 KAEMPFEROL ACTIVATES THE MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX IN A CA 2+ -DEPENDENT MANNER: IMPLICATION OF MICU1 SUBUNITS. Elodie Lamonzie , Mathieu Panel, Lucile Fossier, Amandine Falco, Ramaroson Andriantsitohaina, Didier Rognan, Carmen Martinez, Alain Lacampagne, Jeremy Fauconnier 2982 -Pos Board B374 ENHANCEMENTE OF AMPHOTERICIN B CHANNEL ACTIVITY BY APLPLIED PRESSURES, IN THE RANGE OF MSCHANNEL ACTIVATION, IN ERGOS TEROL CONTAINING MEMBRANES. María T. Haro Reyes 2983 -Pos Board B375 THE MOLECULAR BASIS FOR KCNQ3 ISOFORM-SELECTIVE ACTIVITY OF CARNOSIC ACID. Rían W. Manville , Guilian Tian, Derk Hogenkamp, Kevin T. Beier, Geoffrey W. Abbott 2984 -Pos Board B376 NICLOSAMIDE POTENTIATES TMEM16A AND INDUCES VASOCONSTRIC TION. Pengfei Liang , Yui Chun S. Wan, Kuai Yu, H. Criss Hartzell, Huanghe Yang 2985-Pos Board B377 CHLORIDE INTRACELLULAR CHANNELS (CLICS) REGULATE SPER MATOGENESIS. Veronica Loyo-Celis , Shridhar K. Sanghvi, Satish Raut, Devasena Ponnalagu, Harpreet Singh Board B366

2986-Pos Board B378 CRYO-EM ANALYSIS OF THE MALIGNANT HYPERTHERMIA-CAUSING T4826I MUTANT OF RYANODINE RECEPTOR 1 AND ITS INTERPLAY WITH PHARMACOLOGICAL AGENTS. Yu S. Chen , Maricela García-Castañeda, Paul D. Allen, Filip Van Petegem 2987-Pos Board B379 ENHANCED NA V 1.5 ( SCN5A ) ACTIVATION IN CPVT-LIKE ARRHYTH MIA. Serena Pozzi , Pia Dahlberg, Linda Bulmer, Amaia Jauregi Miguel, Michelle Nilsson, Anders Nygren, Anders Gummesson, Antonios Panta zis 2988 -Pos Board B380 CC6 IS A SPECIFIC ENHANCER OF THE I KS CHANNEL IN THE HEART. Lu Zhao , Xianjin Xu, Virgis Valiunas, Jingyi Shi, Junyuan Gao, Mengqi Gu, Lu Han, Ira.S Cohen, Xiaoqin Zou, Jianmin Cui 2989 -Pos Board B381 STRUCTURAL BASIS FOR CA V Α 2 Δ-GABAPENTIN BINDING . Abhisek Mondal , Zhou Chen, Daniel L. Minor 2990 -Pos Board B382 PROPOFOL RESCUES HCN1 EPILEPSY MUTANTS AND REVEALS NON-CA NONICAL VOLTAGE-DEPENDENT GATING IN HCN CHANNELS. Elizabeth D. Kim , Xiaoan Wu, Sangyun Lee, Gareth R. Tibbs, Kevin P. Cunningham, Marta E. Perez, Peter A. Goldstein, Alessio Accardi, Peter H. Larsson, Crina M. Nimigean Actin Structure, Dynamics, and Associated Proteins (Boards B383 - B403) 2991-Pos Board B383 DISCOVERY OF A FOURTH ACTIN-BINDING SITE ON LEIOMODIN-2. Mad ison Little , Garry E. Smith, Mason Summers, Alan Palma Guillen, Carol Gregorio, Vitold E. Galkin, Alla S. Kostyukova 2992 -Pos Board B384 TNNT2 MUTATIONS IN THE TROPOMYOSIN-BINDING SEGEMENT OF TNT1 ENGENDER DILATED CARDIOMYOPATHY IN DROSOPHILA . Aditi Madan, Kripa Chitre , Elizabeth A. Brundage, Brandon J. Biesiadecki, Anthony Cammarato 2993 -Pos Board B385 EXPLORING THE IMPACT OF MYOPALLADIN IG3 DOMAIN MUTATIONS ON ACTIN INTERACTIONS IN CARDIOMYOPATHY. Asha Rankoth Arach chige , Julie Tran, Alia Michaelis, Ziwei Zhao, Hannah Dammann, Erika Geisbrecht, Moriah R. Beck 2994 -Pos Board B386 SKELETAL MUSCLE ACTIN MUTATION R256H CAUSES CARDIAC HYPO CONTRACTILITY BY DISRUPTING MULTIPLE ACTIN FUNCTIONS DEMON STRATED THROUGH MULTI-SCALE ANALYSIS. Ankit Garg , Silvia Jansen, Rui Zhang, Kory J. Lavine, Michael J. Greenberg 2995-Pos Board B387 BIOCHEMICAL AND STRUCTURAL INVESTIGATION OF ARP2/3 COMPLEX REGULATION BY MAMMALIAN CORONIN-7. Fred E. Fregoso 2996-Pos Board B388 ROLE OF PALLADIN IN ACTIN DYNAMICS REVEALED BY QUANTITATIVE TIRFM. Sanju Ghimire , Wael Yessin, Tariq Izard, Moriah R. Beck 2997-Pos Board B389 INVESTIGATING ALLOSTERIC INHIBITION OF CAPPING PROTEIN BY CPI MOTIF PEPTIDES. Chenbo Yan , David Sept

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