BPS2024 Full Program & Abstracts

136-FlashTalk 12:30 pm ELUCIDATING ION CONFIGURATIONS AND WATER DYNAMICS IN A K + ION CHANNEL USING TWO-DIMENSIONAL INFRARED SPECTROSCOPY. Alexei Kananenka , Matthew Ryan, Lujia Gao, Francis I. Valiyaveetil, 12:35 pm ENGINEERING AN OFF-SWITCH FOR BACKGROUND TREK1 POTASSIUM CHANNELS. Elena B. Riel , Louis Goldberg, Paul M. Riegelhaupt 138-FlashTalk 12:40 pm USING PHOTOLIPIDS TO TRIGGER CHANNEL ACTIVITY BY LIGHT. Rohit Yadav, Jürgen Pfeffermann, Nikolaus Gössweiner-Mohr, Peter Pohl Platform Optical Microscopy and Superresolution Imaging I 10:45 am - 12:45 pm, Room 204AB Co-Chairs Ashwin Balaji, Stanford University, USA Eitan Lerner, The Hebrew University of Jerusalem, Israel 139-Plat 10:45 am SINGLE-MOLECULE LABELING AND LOCALIZATION MICROSCOPY. Ying S. Hu 140-Plat 11:00 am SEGMENTED FCS ON A COMMERCIAL MICROSCOPE TO STUDY DYNAM ICS AND INTERACTIONS IN LIVE CELLS. Elisa Longo , Anna P. Privitera, Silvia Scalisi, Luca Lanzanò 141-Plat 11:15 am FRETSAEL MICROSCOPY - LOCALIZING BIOMOLECULAR INTERACTIONS AT NANOMETER ACCURACY USING CONFOCAL MICROSCOPY AND SIMPLE DYES. Eitan Lerner , Yair Razvag, Paz Drori 142-Plat 11:30 am ECLIPSE: A VERSATILE APPROACH FOR STRUCTURAL AND MORPHO LOGICAL ANALYSIS OF 2D AND 3D SUPER-RESOLUTION FLUORESCENCE MICROSCOPY DATA. Siewert Hugelier , Hannah Kim, Melina Theoni Gyp araki, Charles Bond, Qing Tang, Adriana N. Santiago Ruiz, Silvia Porta, Melike Lakadamyali 143-Plat 11:45 am Travel Award Winner MEASURING LIPID DYNAMICS AND PACKING WITH MINFLUX MICROS COPY. Agnes M. Koerfer , Christian Eggeling, Pablo Carravilla 144-Plat 12:00 pm DYNAMIC SINGLE PARTICLE MEASUREMENTS WITH A COMPACT, HIGH THROUGHPUT ISCAT-TIRF SETUP. Giovanni De Angelis , Jacopo Abramo, Marcel Taubert, Christian Eggeling, Francesco Reina 145-Plat 12:15 pm REVEALING THE 3D NANOSCALE ORGANIZATION OF MYOSINH IN THE APICAL COMPLEX OF TOXOPLASMA GONDII THROUGH SINGLE-MOL ECULE LOCALIZATION MICROSCOPY WITH THE DOUBLE-HELIX POINT SPREAD FUNCTION. Ashwin Balaji , Li-av Segev Zarko, Peter D. Dahlberg, John C. Boothroyd, William E. Moerner 146-FlashTalk 12:30 pm COMPREHENSIVE OPTICAL AND DATA MANAGEMENT PIPELINE FOR 3D RECONSTRUCTION OF SYMPATHETIC NETWORK REMODELING IN CENTIMETERS-SIZE INFARCT BORDER-ZONE OF PIG HEART. Camilla Olianti , Francesco Giardini, Matthew Amoni, Piet Claus, Karin R. Sipido, Leonardo Sacconi Martin T. Zanni 137-FlashTalk

147-FlashTalk 12:35 pm CONNECTING SIMULATION AND EXPERIMENT OF PROTEIN FOLDING INSIDE CELLS WITH FAST RELAXATION IMAGING. Raibat Sarker , Edward R. Knab, Caitlin Davis 148-FlashTalk 12:40 pm INTACT MATRIX-ASSISTED GOLGI EXPANSION VISUALIZED BY BRIGHT AND DARK FIELD MICROSCOPY. Bi-chang Chen , Xuejiao Tian, Chia-Ming Lee, Peilin Chen Platform Protein Dynamics and Allostery I 10:45 am - 12:45 pm, Room 201C Co-Chairs David Scheerer, Weizmann Institute of Science, Israel Joshua Wand, Texas A&M University, USA 149-Plat 10:45 am SUBSTRATE INHIBITION OF AN ENZYME: ARE MICROSECOND MOTIONS AFFECTING CATALYTIC ACTIVITY? David Scheerer , Bharat Adkar, Dorit Levy, Inbal Riven, Eugene Shakhnovich, Gilad Haran 150-Plat 11:00 am CONFORMATIONAL ENTROPY IN PROTEIN STABILITY, MOLECULAR RECOGNITION AND ALLOSTERIC REGULATION. Josh Wand , Anthony C. Bishop, Jose Alfredo Caro, Taylor R. Cole, Sravya Kotaru, Mauricio Lasa gna, Rosana Lopes, Glorise Montalvo-Torres, Kelly Risch, Weimin Tan 151-Plat 11:15 am CROSS-TALK BETWEEN TOXIN DYNAMICS AND K + -CHANNEL BINDING: CONVERGING INSIGHTS FROM NMR AND MD SIMULATIONS. Chen Tim sit, Inbal Sher, Sai Chaitanya Chiliveri, Adriaan Bax, Ruiming Zhao, Steven Goldstein, Dan Major, Jordan H. Chill 152-Plat 11:30 am FRET NOT! MSMFRET REVEALS THE KINETIC CONFORMATIONAL HET EROGENEITY WITHIN SINGLE MOLECULE FRET DISTRIBUTIONS. Justin Miller , Upasana L. Mallimadugula, Maxwell I. Zimmerman, Andrea Soranno, Gregory Bowman 153-Plat 11:45 am TRACKING THE DYNAMICS OF THE CCT/TRIC COMPLEX AT THE SINGLE MOLECULE LEVEL. Kazutaka Araki , Takahiro Watanabe-Nakayama, Yuji C. Sasaki, Kazuhiro Mio 154-Plat 12:00 pm A SIMPLE MUTATION-MINIMIZATION SCHEME ELUCIDATES THE FITNESS LANDSCAPE OF GB1 BINDING TO IGG-FC. Tandac Furkan Guclu , Ali Rana Atilgan, Canan Atilgan 155-Plat 12:15 pm HIGH-THROUGHPUT SAMPLING OF PROTEIN DYNAMICS AT DIFFER ENT STAGES IN EVOLUTION. Michael Sauer , Souvik Mondal, Matthias Heyden 156-FlashTalk 12:30 pm CONFORMATIONAL DYNAMICS OF MAMMALIAN CLOCK PROTEINS: ROLE OF FLEXIBILITY AND DISORDER IN TRANSCRIPTIONAL REGULA TION. Karthik Sudarsha, Ashutosh Srivastava 157-FlashTalk 12:35 pm LIGAND-MODULATED INTER-DOMAIN COMMUNICATION AND LONG RANGE ALLOSTERY IN FULL-LENGTH FXR. Saurov Hazarika

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