BPS2024 Full Program & Abstracts

260-Pos Travel Award Winner NMR STRUCTURAL ANALYSIS OF RETINAL GUANYLYL CYCLASE ACTIVAT ING PROTEIN 5 (GCAP5) WITH A MUTATION (R22A) THAT ABOLISHES DI MERIZATION AND ENHANCES CYCLASE ACTIVATION. Effibe O. Ahoulou , Diana L. Cudia, James B. Ames 261-Pos Board B27 LIGAND AND DNA BINDING EFFECTS ON THE STRUCTURE AND DYNAM ICS OF FARNESOID-X RECEPTOR. Sabab H. Khan , Denise Okafor Protein Structure, Prediction, and Design I (Boards B28 - B50) 262-Pos Board B28 ENGINEERING SELECTIVITY OF SWEET FAMILY TRANSPORTERS USING DEEP MUTATIONAL SCANNING. Lingyun Xu , Diwakar Shukla 263-Pos Board B29 PEPTIDE LENGTH AMPLIFICATION THROUGH SELF-REPLICATION. Victo ria E. Dobbs , Douglas D. Root 264-Pos Board B30 Travel Award Winner HIGH-THROUGHPUT DISCOVERY OF INHIBITORY PROTEIN FRAGMENTS WITH ALPHAFOLD. Andrew Savinov , Sebastian Swanson, Amy E. Keat ing, Gene-Wei Li 265-Pos Board B31 Travel Award Winner SYSTEMATIC STRUCTURAL CHARACTERIZATION OF PROTEIN-POLYMER CONJUGATES PROVIDES CRITERIA FOR RATIONAL CONJUGATE DE SIGN. Emma Mulry , Amanda Pritzlaff, Guillaume Ferre, Matthew T. Eddy 266-Pos Board B32 OPTIMIZING ANTIBODY FABS FOR THEIR USE AS SCAFFOLDS IN CRYO EM. Carla Cabal Fernandez , Massimiliano Bonomi, Chiara Rapisarda 267-Pos Board B33 HARNESSING MOLECULAR SIMULATIONS TO DESIGN STABILIZED SARS COV-2 S2 ANTIGENS. Lorenzo Casalino , Xandra Nuqui, Ling Zhou, Mo hamed Shehata, Albert Wang, Alexandra L. Tse, Anupam A. Ojha, Fiona L. Kearns, Mia A. Rosenfeld, Emily H. Miller, Cory M. Acreman, Surl-Hee Ahn, Kartik Chandran, Jason S. McLellan, Rommie E. Amaro 268-Pos Board B34 DECODING ANTIBODY STRUCTURE AND HYDROPATHY. Jingjing Ji 269-Pos Board B35 A WRITHE BASED APPROACH TO REALISTIC PROTEIN STRUCTURE PRE DICTIONS FROM BIOSAXS DATA AND FLEXIBLE STRUCTURE COMPARI SON. Arron Bale , Christopher Prior 270-Pos Board B36 PUTATIVE TOLL-BINDING PROTEINS MINED FROM MESOBIOTUS PHILIP PINICUS ARE LIKELY RNA-BINDING PROTEINS. Karen Grace E. Joson , Beatrice Gabrielle T. Panlaqui, Rachael Mikaela R. Lao, Neil Andrew D. Bascos, Denise Mirano-Bascos 271-Pos Board B37 NEXT GENERATION IAPP/AMYLIN ANALOGS FOR THE TREATMENT OF DIABETES. Gabriel Brill 272-Pos Board B38 ENERGY BASED CLUSTERING OF PROTEIN STRUCTURES. Tristan Rug giero, Emiliano Brini 273-Pos Board B39 COMPARATIVE ANALYSIS OF PLANAR AND CAPSULE MORPHOLOGIES OF BACTERIAL MICROCOMPARTMENT SHELL PROTEIN ASSEMBLIES. Saad Raza , Daipayan Sarkar, Josh V. Vermaas Board B26

274-Pos Board B40 AUTOMATED METHOD FOR PROPOSING MUTANT SEQUENCES IN A SMALL DOMAIN USING A PROTEIN STRUCTURE-BASED DEEP NEURAL NETWORK. Naoyuki Miyashita , Kazuya Iwano 275-Pos Board B41 STRUCTURAL MODELING OF HUMAN CAV1.2 CHANNEL DIMERIZATION AND INTERACTION WITH CALMODULIN USING ALPHAFOLD. Adriana Hernández González , Vladimir Yarov-Yarovoy, Rose E. Dixon, Igor V. Vorobyov 276-Pos Board B42 RATIONAL ENZYME ENGINEERING VIA GENERATIVE AI. Wenjun Xie 277-Pos Board B43 HLA3DB: COMPREHENSIVE ANNOTATION OF PEPTIDE/HLA COMPLEXES ENABLES BLIND STRUCTURE PREDICTION OF T CELL EPITOPES. Sagar Gupta , Santrupti Nerli, Sreeja Kutti Kandy, Glenn L. Mersky, Nikolaos Sgourakis 278-Pos Board B44 Travel Award Winner DIRECT PREDICTION OF INTRINSICALLY DISORDERED PROTEIN CON FORMATIONAL PROPERTIES FROM SEQUENCE. Jeffrey M. Lotthammer , Garrett M. Ginell, Daniel Griffith, Ryan Emenecker, Alex S. Holehouse 279-Pos Board B45 DESIGN OF PROTEIN FOLD-SWITCHES USING ALCHEMICAL MUTATION FREE ENERGY CALCULATIONS. Lisa Schmidt , Bert L. de Groot 280-Pos Board B46 DE NOVO DESIGN OF A DNA-BINDING PROTEIN CAPABLE OF MULTI-SITE RECOGNITION. Lee A. Solomon , Jacklin Sedhom 281-Pos Board B47 DYNAMICS OF SURFACTANT PROTEIN B AT THE ALVEOLAR AIR-LIQUID INTERFACE: INSIGHTS FROM MOLECULAR MODELING AND SIMULA TIONS. Mona Minkara , Tyler Locke 282-Pos Board B48 DIFFERENCES IN RELEVANT PHYSICOCHEMICAL PROPERTIES CORRELATE WITH SYNERGISTIC ACTIVITY OF ANTIMICROBIAL PEPTIDES. Angela Medvedeva , Hamid Teimouri, Anatoly B. Kolomeisky 283-Pos Board B49 DIRECTED EVOLUTION OF DYNAMIC, MULTI-STATE, AND COMPUTA TIONAL PROTEINS. Sahand Rahi , Vojislav Gligorovski 284-Pos Board B50 DISSECTING FMRP DOMAINS TO RESTORE THE SYNAPTIC FUNCTION IN FRAGILE X-SYNDROME. Gloria Venturini , Ilenia Cirilli, Agnese Roscioni, Alice Romagnoli, Anna La Teana, Daniele Di Marino Protein Stability, Folding, and Chaperones I (Boards B51 - B74) 285-Pos Board B51 SMALL HEAT SHOCK PROTEIN HSPB1: MOLECULAR INSIGHTS INTO ITS STRUCTURAL COMPLEXITY AND CHAPERONE ACTIVITY. Tien M. Phan , Raymond F. Berkeley, Alexander P. Plonski, Galia T. Debelouchina, Jeetain Mittal 286-Pos Board B52 MYO -INOSITOL SUPPRESSES ΓD-CRYSTALLIN AGGREGATION BY INTER ACTING WITH A NON-NATIVE STATE. Constance Kraay , Eugene Sere bryany, Srivastav Ranganathan, Eugene Shakhnovich 287-Pos Board B53 INFLUENCE OF DETERGENTS AND AMINO ACID IONIC LIQUIDS ON THE STABILITY OF AZURIN. Riley Barry, Aashna Jonnalagadda, Emily Mounas, Vidhi Pandya , Victoria Tagliaferro, Samuel Pennock, Chun Wu, Timothy Vaden, Gregory A. Caputo

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