BPS2024 Full Program & Abstracts

288-Pos Board B54 INVESTIGATING THE PROTEASES RESPONSIBLE FOR SPECIFIC SNAP-25 FRAGMENTATION DURING BACTERIAL PRODUCTION. Sean M. Laver ing , Kade W. Johnson, Jurgen C. Mehlhaff, Hunter S. Malquist, Dmitry V. Artemyev, Dixon J. Woodbury 289-Pos Board B55 THERMAL DESTABILIZATION OF AZURIN BY FATTY ACID IONIC LIQ UIDS. Brandon Burrell , Austin K. Clark, Achismita Dutta, Esha Prajapati, Sierra Cottle, Timothy D. Vaden 290-Pos Board B56 Travel Award Winner UBA(2) PROTEIN STABILITY ENHANCEMENT: BRIDGING COMPUTATION AL PREDICTION AND EXPERIMENTAL VALIDATION OF MUTANTS. Bahar Ghazi Esfahani , Michael T. Ruthfuss, Levi J. McClelland, Cindee Yates Hansen, Bruce Bowler 291-Pos Board B57 CHARACTERISTICS OF PHD FINGER BINDING SITE COEVOLVING RESI DUES. Ujwal Subedi , Maral Afshinpour, Suvobrata Chakravarty 292-Pos Board B58 COLD- AND HEAT-DENATURATIONS OF YFH1 ARE OPPOSITELY AFFECTED IN CELLS. Maya Khurana , Ume H. Tahir, Caitlin Davis 293-Pos Board B59 STRUCTURAL CHARACTERIZATION OF THE LIQUID-LIQUID PHASE SEPARATING PROTEIN MCDB. Heather J. Tejeda , Kali N. Pierson, Jacob T. Zangaro, Joseph Basalla, Anthony Vecchiarelli, Nathaniel V. Nucci 294-Pos Board B60 CHARACTERIZATION OF PROTEIN FOLDON PHYSICAL ENERGY LAND SCAPE. Rachel Gilbert 295-Pos Board B61 Travel Award Winner FOLDING AND UNFOLDING OF AN ALPHA-HELICAL LID GOVERN TARGET DOUBLE-STRANDED DNA BREAK IN CAS12A. Aakash Saha , Isabel Strohk endl, Mohd Ahsan, Catherine Moy, Alexander-Hoi Nguyen, Rick Russel, David W. Taylor, Giulia Palermo 296-Pos Board B62 BIOPHYSICAL AND CELLULAR ANALYSIS OF MYOPATHY-LINKED TITIN M10 VARIANTS. Martin Rees , Ay Lin Kho, Robert C. Muirhead, Mark Holt, Livia Occhipinti, Khushi Singh, Ketan Bhadgal, Bjarne Udd, Mathias Gautel 297-Pos Board B63 FLEXIBILITY AND STIFFNESS IN INTERDOMAIN LINKERS OF GAMMA-RET ROVIRUS INTEGRASE PROTEINS. Namita Dube , Monica J. Roth, Gaetano T. Montelione 298-Pos Board B64 DEPENDENCE OF PROTEIN SHAPE AND STABILITY ON ELECTRIC FIELD STRENGTH AND SOLUTION ENVIRONMENT. Sachini Poornima Warsha Withanage , Haopeng Li, Yeasin Ahmed, Ruben M. Ceballos, Jiali Li 299-Pos Board B65 DYNAMIC RIBOSOME BINDING BY TRIGGER FACTOR IN VIVO. Tora Hävermark , Mikhail Metelev, Magnus Johansson 300-Pos Board B66 CALMODULIN IS CRITICAL FOR FOLDING OF THE K V 7.2 CALCIUM RESPONSIVE DOMAIN AS THE NASCENT PEPTIDE EXITS THE RIBO SOME. Arantza Muguruza-Montero , Sara M-Alicante, Ane Metola, Eider Nuñez Viadero, Janire Urrutia, Igone Campos-Zarraga, Covadonga Malo, Gunnar von Heijne, Alvaro Villarroel

301-Pos Travel Award Winner FLUORESCENCE AND SINGLE-PARTICLE CRYO-EM ANALYSIS OF RIBO SOME/NASCENT-GLOBIN COMPLEXES: PROTEIN-PROTEIN INTERAC TIONS AND PHARMACEUTICAL IMPLICATIONS. Hongqing Guan , Meranda Masse, Rachel Hutchinson, Silvia Cavagnero 302-Pos Board B68 THE PURELY THERMODYNAMIC ANTI-PRIONIC MODE OF ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES. Dieter Willbold 303-Pos Board B69 STABILITY VS. ENVIRONMENTAL SENSITIVITY: THE IMPORTANCE OF PRO TEIN SURFACE CHARGE ADAPTATIONS. Edward Knab , Matthew Sternke, Doug Barrick, Martin Gruebele, Caitlin Davis 304-Pos Board B70 MOLECULAR CHAPERONES AND THEIR ROLE IN AMYLOID FORMA TION. Matthias M. Schneider , Andreas Bracher, Ewa A. Andrzejewska, Georg Krainer, Li-Uen Lin, Roland Riek, Ulrich Hartl, Tuomas P.J. Knowles 305-Pos Board B71 INVESTIGATING THE CHAPERONE MECHANISM OF Α-CRYSTALLIN IN PREVENTING ΓD-CRYSTALLIN AGGREGATION IN CATARACT FORMA TION. Deepshikha Ghosh 306-Pos Board B72 BETA-BARREL CHANNEL’S RESPONSE TO HIGH ELECTRIC FIELDS: FUNCTIONAL GATING OR REVERSIBLE DENATURATION? Ekaterina M. Nestorovich , Sergey M. Bezrukov 307-Pos Board B73 A NEWLY PREDICTED CLASS OF PROTEIN MISFOLDING EXPLAINS DECADES-OLD BIOCHEMICAL AND MOLECULAR BIOLOGY DATA. Edward P. O'Brien 308-Pos Board B74 EARLY FORMED NON-LOCAL CONTACTS ARE "NATURES-SHORTCUTS" TO FAST PROTEIN FOLDING. Elisha Haas , Gil Rahamim, Dan Amir Protein Dynamics and Allostery I (Boards B75 - B99) 309-Pos Board B75 STRUCTURAL INSIGHT INTO DIFFERENTIAL INHIBITION OF G PROTEINS BY YM-254890. Tony Trent 310-Pos Board B76 OPTIMAL ENHANCED SAMPLING OF PROTEIN CONFORMATIONAL CHANGES BY EXACT REACTION COORDINATES FROM ENERGY RELAX ATION. Huiyu Li 311-Pos Board B77 UNRAVELING DISTINCT LIGAND INTERACTION PATHWAYS IN LIVER X RECEPTORS-ALPHA AND BETA FOR ISOFORM-SPECIFIC DRUG DE SIGN. Kesaban Sankar Roy Choudhuri , Denise Okafor 312-Pos Board B78 DYNAMIC ALLOSTERY AND THROMBIN: INSIGHTS FROM MODELING MUTANTS, IONS AND BINDING USING MOLECULAR DYNAMICS, STATIS TICAL ANALYSIS AND MACHINE LEARNING. Freddie R. Salsbury , Dizhou Wu, Jiajie Xiao 313-Pos Board B79 COMPUTATIONAL INVESTIGATION OF AMINO ACID SEQUENCE AND DISULFIDE BONDS ON MONOCLONAL ANTIBODY DYNAMICS. Violeta Burns , Christina Bergonzo, Harold W. Hatch 314-Pos Board B80 CONDUCTING ALL-ATOM SIMULATIONS TO UNRAVEL HEME TRANSFER EVENT IN C. DIPHTHERIA HTAA. Kade C. Cheatham , Jeffery M. Wereszc zynski Board B67

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