BPS2024 Full Program & Abstracts

Intracellular Organelle Dynamics (Boards B334 - B339)

579-Pos Board B345 ELUCIDATING THE EFFECTS OF DISEASE-ASSOCIATED MUTATIONS ON FAST-INACTIVATION IN VOLTAGE-GATED SODIUM CHANNELS. Shiva Akhlaghi , Jing Li 580-Pos Board B346 COMPUTATIONAL DESIGN OF BINDERS TARGETING THE VSDIV FROM NAV1.7 SODIUM CHANNEL. Diego Lopez Mateos , Adam M. Murray, Hai M. Nguyen, Preetham Venkatesh, Brian Koepnick, David Baker, Heike Wulff, Vladimir Yarov-Yarovoy 581-Pos Board B347 DE NOVO PROTEIN DESIGN TARGETING VOLTAGE-GATED SODIUM CHANNEL 1.7 USING RFDIFFUSION AND ALPHAFOLD2. Brandon J. Har ris , Amogh Sukhthankar, Vladimir Yarov-Yarovoy 582-Pos Board B348 ELUCIDATING THE DIFFERENTIAL VARIANT EFFECTS OF GATING CHARG ES IN NA V CHANNELS. Eslam Elhanafy , Amin Akbari Ahangar, Jing Li 583-Pos Board B349 ANETHOLE INHIBITS VOLTAGE-GATED NA + CHANNELS IN SENSORY NEU RONS. Luiz Moreira Junior , Joao L. Carvalho-de-Souza 584-Pos Board B350 EFFECTS OF STATE-DEPENDENT DRUG BLOCK OF THE NAV1.7 SODIUM CHANNEL ON CURRENT AND ACTION POTENTIAL BEHAVIOR IN A DYNAMIC CLAMP IN SILICO DRG NEURON. Leigh Korbel, Lars Nilsson, Swapnil Pandey, Samuel Struble, Glenna Bett, Randall L. Rasmusson, Mark W. Nowak 585-Pos Board B351 Travel Award Winner ACUTE INDUCTION OF L-TYPE CA V CHANNEL INHIBITION VIA MEM BRANE-TRANSLOCATED PEPTIDES ENCODING CA V 1. Jinli Geng , Boying Li, Zhen Yu, Yi Liu, Yubo Fan, Yaxiong Yang, Chengfen Xing, Xiaodong Liu 586-Pos Board B352 THE PATHOGENIC N1662D MUTATION REVEALS AN ESSENTIAL MOLECU LAR INTERACTION FOR NA V 1.2 CHANNEL INACTIVATION. Geza Berecki , Elaine Tao, Katherine B. Howell, Kristopher M. Kahlig, Markus Wolff, Ben Corry, Steven Petrou 587-Pos Board B353 MOLECULAR DYNAMICAL SIMULATIONS OF NACHBAC STATE DEPEN DENT VOLTAGE SENSOR BINDING FOR ANTIEPILEPTIC DRUGS. Zubair Jashim, Chris French 588-Pos Board B354 THE COIL-COILED DOMAIN IS DETERMINANT FOR THE TEMPERATURE DEPENDENCE OF A BACTERIAL VOLTAGE-GATED SODIUM CHAN NEL. Carlos Gonzalez-Leon, Gerhard Hummer, Sonya M. Hanson, Andres Jara Oseguera 589-Pos Board B355 MOLECULAR DYNAMICS SIMULATIONS REVEAL MOLECULAR MECHA NISMS FOR THE GAIN AND LOSS OF FUNCTION EFFECTS OF FOUR SCN2A VARIANTS. Nisha Bhattarai , Ludovica Montanucci, Tobias Bruenger, Eduardo Perez-Palma, William Martin, Iris N. Smith, Feixiong Cheng, Charis Eng, Ingo Helbig, Rikkie S. Moller, Andreas Brunklaus 10 , Stephanie Schorge 11 , Dennis Lal 590-Pos Board B356 BINDING OF DIVERSE INHIBITORS IN THE SODIUM CHANNEL PORE. Elaine Tao , Ben Corry 591-Pos Board B357 STUDYING STATE-DEPENDENT COMPOUND EFFECTS USING ADAPTIVE VOLTAGE-CLAMP ON A HIGH THROUGHPUT AUTOMATED PATCH CLAMP SYSTEM. Michael George , Tom A. Götze, Nina Brinkwirth, Søren Friis, Claudia Haarmann, Nadine Becker, Niels Fertig

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568-Pos Board B334 INVESTIGATING BETA CELL STRUCTURAL HETEROGENEITY USING SOFT X-RAY TOMOGRAPHY. Kevin S. Chang , Aneesh Deshmukh, Kate L. White, Valentina Loconte 569-Pos Board B335 SOFT X-RAY TOMOGRAPHY REVEALS COORDINATED MECHANISM OF DIVISION OF AN ORGANELLE-LIKE ENDOSYMBIONT AND ITS HOST CELL. Valentina Loconte , Kendra Turk-Kubo, Bieke Vanslembrouck, Wing Kwan Esther Mak, Axel Ekman, Jian-Hua Chen, Yoshihito Takano, Takeo Horiguchi, Mark A. Le Gros, Kyoko Hagino, Jonathan P. Zehr, Carolyn A. Travel Award Winner INVESTIGATING THE USE OF DIRECT CURRENT INSULATOR-BASED DI ELECTROPHORESIS TO STUDY INSULIN VESICLE SUBPOPULATIONS. Ash ley Archambeau , Mahta Barekatain, Zhongying Wang, Vadim Cherezov, Scott E. Fraser, Kate L. White, Mark A. Hayes 571-Pos Board B337 DYNAMIN FUNCTION IN PANCREATIC BETA CELL AUTOPHAGY. Fan Fan, Xuelin Lou 572-Pos Board B338 A BUOYANT NUCLEUS IS A UNIVERSAL CHARACTERISTIC OF EUKARYOTIC CELLS. Abin Biswas, Kyoohyun Kim, Omar Munoz, Vasily Zaburdaev, Simone Reber, Jochen Guck 573-Pos Board B339 Travel Award Winner COLLAPSE OF CANCER CELL MICRONUCLEI FROM MITOCHONDRIAL DERIVED OXIDATIVE STRESS. Melody Di Bona , Yanyang Chen, Albert S. Agustinus, Matthew Deyell, Mercedes A. Duran-Paez, Christy Hong, Daniel Bronder, Lorenzo Scipioni, Alban Ordureau, Ashley Laughney, Enrico Gratton, John Maciejowski, Thomas Jeitner, Samuel F. Bakhoum Voltage-Gated Na Channels (Boards B340 - B365) 574-Pos Board B340 Travel Award Winner EFFECTS OF MEXILETINE AND ITS PYRROLINE DERIVATIVE ON NA V 1.4 AND NA V 1.5 BY AUTOMATED PATCH-CLAMP: TOWARDS SAFER ANTI MYOTONIC DRUGS. Alessandro Giovanni Cerchiara , Nadine Becker, Niels Fertig, Ornella Cappellari, Michela De Bellis, Alessia Carocci, Giovanni Lentini, Jean-Francois Rolland, Paola Imbrici, Annamaria De Luca 575-Pos Board B341 COMPARISON OF TWO FAST-INACTIVATION DEFICIENT MUTANTS IN VOLTAGE-GATED SODIUM CHANNEL. Yichen Liu , Francisco Bezanilla 576-Pos Board B342 A MECHANISTIC REINTERPRETATION OF FAST INACTIVATION IN VOLTAGE-GATED NA + CHANNEL. Yichen Liu , Carlos Bassetto Jr, Bernardo Pinto, Francisco Bezanilla 577-Pos Board B343 S -PALMITOYLATION OF NA V 1.7 VOLTAGE-GATED SODIUM CHANNELS REGULATES THEIR ACTIVITY AND VOLTAGE SENSITIVITY. Paz Duran , Cheng Tang, Santiago Loya-Lopez, Aida Calderon-Rivera, Kimberly Go mez, Afroze Chimthanawala, Samantha Perez-Miller, Saumya Saurabh, Rajesh Khanna 578-Pos Board B344 CALMODULIN ENABLES INTRACELLULAR FIBROBLAST GROWTH FACTOR REGULATION OF NAV1.5 INACTIVATION. Lucy S. Woodbury , Martina Marras, Anna Li, Paweorn Angsutararux, Jonathan R. Silva Larabell 570-Pos Board B336

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