BPS2026 Program Book

Protein Design (Boards B1 - B27)

2055-Pos Board B13 ULTRA-HIGH THROUGHPUT IN VITRO PROTEIN CHARACTERIZATION WITH AMPLICON/PROTEIN BEAD DISPLAY. Daria Passow , Polly Fordyce 2056-Pos Board B14 ARTIFICIAL REGULATION OF RAS GTPASE ACTIVITY VIA CAM/M13-FUSED RAS-BINDING DOMAIN. Ziyun Zhang , Nobuyuki Nishibe, Shinsaku Maruta 2057-Pos Board B15 RESIDUE PACKING MOTIFS THAT GOVERN ANTIBODY-ANTIGEN BIND ING: KNOB-SOCKET ANALYSIS. Kalee Thao , Hyun Joo, Jerry Tsai 2058-Pos Board B16 DE NOVO PROTEIN DESIGN OF TALE-BASED PROTEIN BINDERS TO TAR GET NON-CANONICAL DNA FORMS. Luke Sebastian , Neville Bethel 2059-Pos Board B17 DESIGNING MULTI-TARGETING PROTEIN BINDERS TO COMBAT ANTIBI OTIC RESISTANCE. Sarah A. Johnson , Neville Bethel, Adrian Jinich 2060-Pos Board B18 PROTEIN DESIGN APPROACHES TO INVESTIGATE PROTEIN-GLYCAN INTERACTIONS. Enrico Ysmael S. Arambulo , Neville Bethel, Alex J. Guse man 2061-Pos Board B19 AI, HIGH THROUGHPUT MOLECULAR DYNAMICS AND EXPERIMENTAL BIOLOGY FOR THE DISCOVERY, OPTIMIZATION AND CHARACTERIZATION OF ANTIMICROBIAL PEPTIDES. Kinjal Mondal , Ella Mihailescu, Antonio Cardone, Jeffery B. Klauda 2062-Pos Board B20 DE NOVO DESIGN OF PROTEIN BINDERS FOR PROGRAMMABLE CON TROL OF BIOMOLECULAR CONDENSATES. Duc Duy Vu , Marie-Aude Plamont, Enzo Rakotomalala-lo, Sadek Amhaz, Zoher Gueroui, Massimil iano Bonomi 2063-Pos Board B21 FROM UBIQUITIN TO BARREL: COMPUTATIONAL DESIGN OF A DE NOVO PROTEIN FOLD-SWITCH. Lisa Schmidt , Bert L. de Groot 2064-Pos Board B22 COMPUTATIONAL DESIGN OF PROTEIN MINI-BINDERS AND MACRO CYCLES TARGETING CAV1.2 CHANNELS. Adriana Hernández González , Rose E. Dixon, Vladimir Yarov-Yarovoy 2065-Pos Board B23 A MODEL FOR THE SEQUENCE SPACE OF A PROTEIN FAMILY. Emily C. Hinds , Yaakov Kleeorin, Michael Socolich, Rama Ranganathan 2066-Pos Board B24 DE NOVO DESIGN OF LIGHT-DRIVEN PROTEIN MOTOR DOMAINS. Kathryn Shelley , Cullen Demakis, David Baker 2067-Pos Board B25 COMPUTATIONAL DESIGN OF PROTEIN ALLOSTERY. Devlin C. Swanson , Neville Bethel 2068-Pos Board B26 PROBABILISTIC DEEP LEARNING ENABLES THE DATA-DRIVEN DESIGN OF DISORDERED PROTEINS. Jeffrey M. Lotthammer , Borna Novak, Alex S. Holehouse 2069-Pos Board B27 DECONSTRUCTING THE COMPLEXITY: UNDERSTANDING ATP BINDING WITH DE NOVO DESIGN AND COMPONENT PARTS. Lee A. Solomon , Robert Spaine, Kenneth Foreman, Qinyi Zhong, Amber Middleton

2043-Pos Board B1 DYNAMICS INFORMED MACHINE LEARNING: PHYSICS-GUIDED FEATURE IMPORTANCE IDENTIFIES KEY RESIDUES FOR ENZYME DESIGN. Michael A. Sauer , Souvik Mondal, Matthias Heyden 2044-Pos Board B2 PROBING THE RULES OF PROTEIN STRUCTURE-FUNCTION RELATION SHIPS THROUGH THE DESIGN OF FUNCTIONAL PROTEINS WITH FINE TUNED STABILITY. Lee Schnaider , William DeGrado 2045-Pos Board B3 STRUCTURE-GUIDED COMPUTATIONAL ENGINEERING OF PREFUSION STABILIZED ALPHACORONAVIRUS S2 IMMUNOGENS. Adonis A. Rubio , Yu Lee, Christopher O. Barnes 2046-Pos Board B4 DEVELOPING FINELY-TUNED RFDIFFUSION GUIDING POTENTIALS FOR FAVORABLE GENERATIVE SAMPLING. Kush Narang , Brandon J. Harris, Vladimir Yarov-Yarovoy 2047-Pos Board B5 PEPTIDE ENGINEERING OF HEAT-STABLE ENTEROTOXIN ANALOGS FOR BORON NEUTRON CAPTURE THERAPY. Yuji Hidaka , Nana Sakata, Shigeru Shimamoto 2048-Pos Board B6 EXTRACELLULAR PROTEIN SCAFFOLDS FOR DE NOVO PEPTIDE NANO PORES TO ADVANCE AMINO ACID IDENTIFICATION. Ayaka Nakada , Ryuji Kawano 2049-Pos Board B7 AN ITERATIVE DE NOVO ANTIBODY DESIGN PIPELINE FOR AFFINITY OPTIMIZATION AGAINST COXSACKIEVIRUS A6 CAPSID PROTEINS. Eshan Thilakaratne , Alvin Yu 2050-Pos Board B8 ENHANCING PROTEIN THERMOSTABILITY AND DNA-BINDING FUNC TION BY PROTEIN DESIGN. Kaylee M. Tani , Isabela Camacho, Michelle E. McCully 2051-Pos Board B9 OUTFITTING A BINDING INTERFACE: A KNOB-SOCKET DESCRIPTION OF PDZ DOMAIN PEPTIDE LIGAND SPECIFICITY. Margit Klemer De Lasse , Board B10 DE NOVO DESIGNED RHODAMINE BINDERS FOR ADVANCED FLUO RESCENCE MICROSCOPY. Klaus Yserentant , Yuda Chen, Kibeom Hong, Yiming Kuang, Arghya Bhowmick, Arthur Charles-Orszag, Samuel J. Lord, Lei Lu, Kaipeng Hou, Samuel I. Mann, Jonathan B. Grimm, Luke D. Lavis, Dyche Mullins, William F. DeGrado, Bo Huang 2053-Pos Board B11 DYNAMIC-STRUCTURE REDESIGN OF CALMODULIN REDUCES CA²⁺ LEAK AND REVEALS MECHANISTIC INSIGHTS INTO RYR2 REGULATION. Vladimir Bogdanov , Svetlana Tikunova, Robyn T. Rebbeck, Mahmuda Akter, Daniel Blackwell, Bjorn C. Knollmann, Razvan L. Cornea, Peter Kekenes-Huskey, Steffen Lindert, Christopher N. Johnson, Sandor Gy orke, Jonathan P. Davis 2054-Pos Board B12 MECHANISM OF ACTION OF HUMAN GROWTH HORMONE (HGH) AN TAGONIST. Hemant Nagar , John J Kopchick, Sumit Sharma Jerry Tsai 2052-Pos

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