BPS2026 Program Book

L2900-Pos Board LB72 MUTATION-DEPENDENT ELECTROPHYSIOLOGICAL DYNAMICS AND PHARMACOLOGIC VULNERABILITIES IN MYBPC3-R943X CARDIOMYO CYTES. Mena Abdelsayed , Efthimios Tim Gianitsos, Alice Yu, Mark Mercola L2901-Pos Board LB73 SAXIPHILIN FUNCTIONS AS A “TOXIN SPONGE” PROTEIN THAT COUN TERACTS THE EFFECTS OF SAXITOXIN POISONING. Sandra Zakrzewska , Samantha A. Nixon, Seil Jang, Keli Huang, Anissa Bara, Zhou Chen, Daynen R. Goss, Elizabeth R. Park, Jutsin Du Bois, Daniel L. Minor L2902-Pos Board LB74 HIGH-THROUGHPUT ELECTROPHYSIOLOGICAL METHODS ENABLING EARLY DRUG DISCOVERY FROM NATIVE LYSOSOMES. Markus Rapedius, Nicoletta Murciano, Bastian Masson, Rocco Zerlotti, Andre Bazzone, Timothy Strassmaier, Søren Friis, Alexandre SANTINHO, Abdou-Rachid THIAM, Maria Barthmes, Alison Obergrussberger , Cecilia George, Mi chael George, Niels Fertig L2903-Pos Board LB75 A WINDOW INTO TREK PHARMACOLOGY: A CONSERVED CONFORMA TION DEPENDENT MECHANISM FOR THE TREK CHANNEL INHIBITORS CARVEDILOL AND FLUPHENAZINE. Joelle Reich , Stephen J. Tucker, Conor McClenaghan L2904-Pos Board LB76 EFFECT OF SERA FROM LONG COVID PATIENTS ON PERIPHERAL NEU RON ACTIVITY. Jeong Sook Kim-Han, Angel Nunez-Correa, Khrystyna Y. Sukhanova, Eugen V. Khomula, Monica Verduzco-Gutierrez, Mark S. Shapiro , Keith S. Elmslie L2905-Pos Board LB77 SLOW PACEMAKING IN HYPOTHALAMIC A11 DOPAMINE NEURONS. An gela F. Smith, Hannah N. Rust, Kathleen A. Sluka, Stephanie C. Gantz L2906-Pos Board LB78 PRO-ARRHYTHMIC ROLE OF PANX1 IN CASQ2-/- MOUSE MODEL OF CPVT2. Dmytro O. Kryshtal , Kyungsoo Kim, Paxton A. Ritschel, Bjorn C. Knollmann Anion Channels (Boards LB79 - LB80) L2907-Pos Board LB79 ABLATION OF CHLORIDE INTRACELLULAR CHANNEL, CLIC4, IN HEART PROTECTS AGAINST TYPE 2 DIABETES ASSOCIATED CARDIOMYOPATHY BY MODULATING MITOCHONDRIAL PHYSIOLOGY. Ty E. Williams , Shrey Stallard, Maren Klineberg, Harpreet Singh, Devasena Ponnalagu L2908-Pos Board LB80 ALLOSTERIC COUPLING OF PIP 2 AND CA 2+ BINDING SITES GATE TME M16A. Ralph C. Kissell , Jie Xu, Ana Santa Cruz, Aishwarya Chandrashek ar, Takeharu Kawano, Mehreen Zaka, Zhe Zhang, Meng Cui, Diomedes E. Logothetis, Leigh D. Plant Microtubules, Structure, Dynamics, and Associated Proteins (Boards LB81 - LB86) L2909-Pos Board LB81 TUBULIN-CRYPTOPHYCIN RING POLYMERS STUDIED BY SINGLE-MOLE CULE METHODS: DEEP ETCH ELECTRON MICROSCOPY, MASS PHOTOM ETRY, AND CRYOELECTRON MICROSCOPY. Felipe A. Montecinos-Franjola, Norman Watts, John E. Heuser, Dan L. Sackett

L2910-Pos Board LB82 SINGLE-MOLECULE MEASUREMENTS REVEAL AN INTERMEDIATE STATE AND CLARIFY THE ROLE OF NUCLEOTIDE IN MICROTUBULE DYNAM ICS. Saradamoni Mondal, Eric Bonventre, William O. Hancock , Luke Rice L2911-Pos Board LB83 MICROTUBULES IN THE AXON ARE GDP-BOUND BUT ADOPT A STABLE GTP-LIKE EXPANDED STATE. Elena A. Zehr , Shufeng Sun, Antonina Roll Mecak L2912-Pos Board LB84 THE MAMMALIAN SKA COMPLEX IS REQUIRED FOR KINETOCHORE MOTION AT METAPHASE AND APPEARS TO REDUCE FRICTION AT THE KINETOCHORE-MICROTUBULE INTERFACE. David Gomez Siu , Vanna Tran, Sophie Dumont L2913-Pos Board LB85 THE JUNCTOPHILIN ALPHA-HELIX ASSOCIATES WITH MICROTU BULES. Luis A. Valencia , Bianxiao Cui L2914-Pos Board LB86 A COMPUTATIONAL PIPELINE FOR QUANTIFYING KINETOCHORE DEFOR MATIONS IN LIVE CELLS. Jinghui Tao , Vanna Tran, Sophie Dumont Cytoskeletal Assemblies and Dynamics (Boards LB87 - LB92) L2915-Pos Board LB87 CELL MACHINE INTERFACES FOR STUDYING COLLECTIVE CELL BEHAV IOR. Nicholas R. Martin , Orion Weiner L2916-Pos Board LB88 PROBING MECHANICAL VULNERABILITIES OF THE MAMMALIAN MITOTIC SPINDLE UNDERLYING KIF18A SENSITIVITY IN CANCER. Valerie Myers , Caleb J. Rux, Nathan H. Cho, Sophie Dumont L2917-Pos Board LB89 DISASSEMBLY-MEDIATED CONTROL OF CYTOSKELETAL ASSEMBLY AND SIZE FLUCTUATIONS IN A SHARED POOL. Md Sorique Aziz Momin , Lishibanya Mohapatra L2918-Pos Board LB90 HUMAN CANCER CELLS BUILD MULTIPOLAR SPINDLES IN A NUMA DEPENDENT MANNER. Nathan H. Cho , Sophie Dumont L2919-Pos Board LB91 MAMMALIAN CELLS DELAY ANAPHASE ENTRY WITH THREE, BUT NOT ONE, SISTERLESS KINETOCHORES. Maddie Blaauw , Megan K. Chong, Miquel Rosas-Salvans, Nathan H. Cho, Sophie Dumont L2920-Pos Board LB92 A MECHANOCHEMICAL PROGRAM DRIVES BISTABLE CHIRAL MORPHO GENESIS. Chris Anto , Nico Romeo, Avi Strok, Emily Hendricks, Fridtjof Brauns, Noah P. Mitchell Cell Mechanics, Mechanosensing, and Motility (Boards LB93 - LB97) L2921-Pos Board LB93 INVESTIGATION OF MECHANOTRANSDUCTION ALTERATIONS IN AGED MUSCLE STEM CELLS. Hannaneh Kabir , Michael Conboy, Phillip Messer smith, Irina Conboy

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