BPS2026 Program Book

Exhibitor Registration 8:00 am - 5:00 pm, South Lobby Drug Discovery for Ion Channels XXVI Satellite Meeting 8:00 am - 5:15 pm, Esplanade, Room 153 Sponsored by AXXAM S.p.A.; Fujifilm; Ion Biosciences; Nanion Technologies; and Sophion Bioscience Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrep resented target class for drug discovery. The advent of higher throughput automated electrophysiology systems changed the face of ion channel drug discovery. Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instru mentation and techniques. For this year, we propose to continue the “Satellite Meeting” tradition at the Biophysical Society Annual Meeting and review the advances ion channel drug discovery. This year’s meeting will highlight presentations from drug discovery companies, companies that provide ion channel services to drug dis covery companies and companies that provide products to ion channel drug discovery companies, as well as other speakers in the field of ion channel drug discovery, including several academic speakers. 8:00 AM REGISTRATION AND COFFEE 8:30 AM WELCOME AND OPENING REMARKS SESSION I Chair: Niels Fertig, Nanion, Germany 8:45 AM SENSING VOLTAGE IN BK CHANNELS: A TALE OF TWO SENSORS. Keynote Speaker: Ramon Latorre 9:30 AM REVISITING ION CHANNEL REGULATION BY NEDD4 FAMILY E3 LIGASES. Henry Colecraft 10:00 AM DIVERSE MECHANISMS IN THE PATHOGENESIS OF CALCIUM CHANNELO PATHIES. Ivy Dick 10:30 AM COFFEE BREAK SESSION II Chair: Jean-Francois Rolland, Axxam, Italy 11:00 AM DISTINCT MECHANISM OF ACTIVATING LYSOSOME ION CHANNEL TMEM175. Tianbo Li 11:30 AM VIRTUAL SCREENING FOR MODULATORS OF KCA, GABA A AND NAV1.7 CHANNELS. Heike Wulff

12:00 PM SELECTIVE POTENTIATION OF NAV1.1 CHANNELS IN A MODEL OF DRA VET SYNDROME. Esteban Suarez Delgado 12:30 PM LUNCH (PROVIDED) SESSION III Chair: Eugenia Jones, FujiFilm Cellular Dynamics (FCDI), USA 1:30 PM NAVIGATING THE MAZE OF APOL1 GENETICS TO DEVELOP NEW PRECI SION MEDICINES FOR KIDNEY DISEASE. Victoria Assimon 2:00 PM DECODING THE MOLECULAR QR CODE OF PAIN: FROM MECHANISM TO THERAPEUTIC TRANSLATION. Rajesh Khanna 2:30 PM GABA B RECEPTOR-MEDIATED MODULATION OF SENSORY NEURON EX CITABILITY: ROLES OF CAV2.2, GIRK, AND HCN CHANNELS IN NOCICEP TION. David Adams 3:00 PM COFFEE BREAK SESSION IV Chair: Derek Hernandez, Ion Biosciences, USA 3:30 PM DRUGGING BIOELECTRIC STRESS: ION CHANNELS AS GATEKEEPERS OF REDOX COLLAPSE AND TUMOR SUPPRESSION. Saverio Gentile 4:00 PM EXTRACELLULAR ACTIVATION OF HCN4 BY A SUBTYPE-SPECIFIC NANO BODY. Anna Moroni 4:30 PM FUNCTIONAL CHARACTERIZATION OF MISSENSE MUTATIONS IN POLY CYSTIN CHANNELS REVEAL NEW THERAPEUTIC AVENUES FOR ADPKD. Markus Delling 5:00 PM CLOSING REMARKS Daniel Sauter, Sophion Bioscience, USA Registration

F R I D A Y

3:00 pm - 5:00 pm, South Lobby New Council Orientation

3:30 pm - 4:30 pm, Marriott Marquis, Foothill F Joint Council Reception, Dinner, and Meeting 5:00 pm - 9:00 pm, Marriott Marquis, SoMa

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