BPS2026 Program Book

268-Pos Board B80 CELL-FREE SYNTHESIS AND SMALP SOLUBILIZATION FOR FUNCTIONAL ANALYSIS OF MEMBRANE PROTEINS. Shakiba Nikfarjam , Gregory Bude, Claire Robertson, Wei He, Matthew A. Coleman Enzyme Function, Cofactors and Post-Translational Modifications (Boards B81 - B98) 269-Pos Board B81 LYSINE SUCCINYLATION IN CHARGE RICH PROTEINS MEASURED USING A NOVEL LABEL FREE TOOL. Himanshi M. Devi , Simangka Bor Saikia, Rajaram Swaminathan 270-Pos Board B82 WHO’S REALLY IN CHARGE ? DISSECTING DIRECTIONAL ELECTRIC FIELDS IN ENZYME CATALYSIS. Srijit Mukherjee , Steven D.E. Fried, Irimpan I. Mathews, Steven G. Boxer 271-Pos Board B83 INTERPLAY OF ELECTROSTATICS AND CONFORMATIONAL DYNAMICS IN DIHYDROFOLATE REDUCTASE CATALYSIS. Steven D.E. Fried , Srijit Mukherjee, Irimpan I. Mathews, Steven G. Boxer 272-Pos Board B84 ISOPRENOID BIOSYNTHESIS IS A METABOLIC VULNERABILITY IN THE LYME DISEASE PATHOGEN BORRELIA BURGDORFERI. Isaac A. Paddy 273-Pos Board B85 EXPLORING FUNCTIONAL CONSEQUENCES OF POST-TRANSLATIONAL MODIFICATIONS TO ARGININOSUCCINATE SYNTHETASE 1. Lucky Gu rung , Michelle Von Merta-Sustarich, Eric R. Greene 274-Pos Board B86 FORCE FIELD DEVELOPMENT AND QUANTUM APPROACHES TO COPPER MEDIATED BIOLOGICAL METHANE OXIDATION. Joshua W. Peterson , Ryan Carlsen, Jessica M. Swanson 275-Pos Board B87 UNCOVERING REGULATION OF BIFUNCTIONAL ENZYMES WITH OPPOS ING ACTIVITIES. Haneen Alkabbani , Cyrina Joy Geluz, Patrick Sherry, Vijay Jayaraman, Eric R. Greene 276-Pos Board B88 CHARACTERIZING AND OPTIMISING TRANSHYDROGENASE SYSTEMS FOR REDOX BALANCE IN METABOLIC PATHWAYS. Patrick Sherry , Haneen Alkabbani, Eric R. Greene, Cyrina Joy Geluz, Vijay Jayaraman 277-Pos Board B89 TOWARDS A STRUCTURAL BASIS FOR ASS1 REGULATION. Danya Abdal lah , Jeanan Ahmad, Jerrade Domingo, Lucky Gurung, Michelle Von Merta-Sustarich, Ryan Leung, Eric R. Greene 278-Pos Board B90 MECHANISM UNDERLYING GLUTAMINE SYNTHETASE INHIBITION BY ADENYLATION. Andrew A. Bautista , Eric R. Greene 279-Pos Board B91 CONFORMATIONAL LANDSCAPE ALTERATION BY COVALENT MODIFICA TION OF PESTICIDE TO ARGININOSUCCINATE SYNTHETASE REVELEADED BY CRYOEM. Michelle J. Von Merta-Sustarich 280-Pos Board B92 ENDOGENOUS METABOLITE ACTIVITY OF HUMAN GLUTAMINE SYNTHE TASE REVEALS INFLAMMATION LINK. Rowan Jacobs , Ryan Leung, Eric R. Greene

281-Pos Board B93 THE NUCLEOPORIN GLE1 STIMULATES DEAD-BOX PROTEIN 5 (DBP5) ATPASE AND PROMOTES DBP5-RNA BINDING TO MEDIATE RNA EX PORT. Zane Lombardo , Wenxiang Cao, Enrique M. De La Cruz 282-Pos Board B94 PURIFICATION AND CHARACTERIZATION OF THE IRON OXIDIZING PORIN, CYTOCHROME CYC2, FROM SEAFLOOR IRON-RICH MICROBIAL MATS. Josiane Azizi , Alain Dolla, Céline Rommevaux, Latifa Elantak, Hélene Gaussier, Matthieu Nouailler 283-Pos Board B95 A NOVEL SPECTROSCOPIC APPROACH FOR DETECTING GLYCATION IN HUMAN SERUM ALBUMIN. Simangka Bor Saikia , Himanshi M. Devi, Rajaram Swaminathan 284-Pos Board B96 DISSECTING THE ACTIVATION MECHANISM OF THE BI-FUNCTIONAL KINASE/RNASE IRE1 WITH ORTHOGONAL CONTROL OVER OLIGOMER IZATION AND PHOSPHORYLATION. Swapnil Mukherjee , Vladislav Belyy 285-Pos Board B97 HIGH-THROUGHPUT BIOCHEMICAL PHENOTYPING OF SHP2 VARIANTS REVEALS MOLECULAR BASIS OF DISEASES AND ALLOSTERIC DRUG INHI BITION. Albert A. Lee , Daniel Mokhtari, Emily Egan, Stephen Blacklow, Dan M. Herschlag, Polly Fordyce 286-Pos Board B98 MECHANISTIC INSIGHT INTO DISEASE VARIANTS OF HUMAN GLUTA MINE SYNTHETASE. Emilio Mejia, Hiroki Yamamura, Markus Tecson, Emma Carroll, Eric R. Greene Intrinsically Disordered Proteins I (Boards B99 - B132) 287-Pos Board B99 X-RAY FOOTPRINTING / MASS SPECTROMETRY PROVIDES A NEW, DETAILED VIEW OF INTRINSICALLY DISORDERED PROTEIN STRUCTURAL ENSEMBLES. Darren N. Kahan , Sayan Gupta, Aditya Udupa, Sveinn Bjarnason, Petur O. Heidarsson, Max V. Staller, Corie Y. Ralston, Susan Marqusee 288-Pos Board B100 DECIPHERING DISORDERED REGIONS CONTROLLING MRNA DECAY IN HIGH-THROUGHPUT. Joseph H. Lobel , Nicholas T. Ingolia 289-Pos Board B101 INTRINSICALLY DISORDERED CONSERVED MOTIFS OF C-MYC ENCODE SELECTIVE PROTEIN INTERACTIONS. Karishma Krishnakumar, Zhaowei Chen, David Lane, Marie Arsenian-Henriksson, Michael Landreh, Dilraj Lama 290-Pos Board B102 Travel Award Winner INTRA-CHAIN INTERACTIONS MODULATE THE EFFECT OF DANGLING ENDS ON POLYMER DYNAMICS AND PHOTO-INDUCED ELECTRON TRANSFER EXPERIMENTS OF IDPS. Crystal F. Ottoway , Nick Lamb, Gabor Nagy, Gerdenis Kodis, Kingshuk Ghosh, Sara M. Vaiana 291-Pos Board B103 MOLECULAR DYNAMICS SIMULATIONS REVEAL FOLDING PATHWAYS OF THE FUNCTIONAL AMYLOID FAPC. Mert Golcuk , Kasper H. Hansen, Chang Byeon, Abdulkadir Tunc, Emilie Buhl Plechinger, Morten K.D. Due holm, James Conway, Maria Andreasen, Umit Akbey, Mert Gur 292-Pos Board B104 PROBING THE MECHANISM OF COUPLED FOLDING/BINDING OF HIF1A CTAD TO CBP TAZ1 WITH 3-COLOR SINGLE-MOLECULE FRET. Sean P. Carney , Jae-Yeol Kim, Hoi Sung Chung

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