BPS2026 Program Book

Enzyme Function, Cofactors and Post- Translational Modifications (Boards LB37 - LB41) L2498-Pos Board LB37 TRANSLOCATION OF PROTEIN ACROSS MEMBRANE WITHOUT UN FOLDING BY MITOCHONDRIAL AAA PROTEIN BCS1. Di Xia , Jingyu Zhan, Yangang Pan, Rick Huang, Simon Scheuring L2499-Pos Board LB38 INVESTIGATION OF RIC8-GALPHA-I NUCLEOTIDE EXCHANGE ACTIV ITY. Fiona Morrow , Levi J. McClelland L2500-Pos Board LB39 COUPLING HIGH-THROUGHPUT PROTEASE ENZYMOLOGY WITH VIRAL REPLICATION REVEALS BIOCHEMICAL CONSTRAINTS OF VIRAL FIT NESS. Dylan Aidlen L2501-Pos Board LB40 DYNAMIC STRATEGIES FOR THE EVOLUTION OF ENZYME TEMPERATURE ADAPTATION. Hayden Saunders L2502-Pos Board LB41 SEQUENCE DETERMINANTS OF PATHOGENICITY AND ALLOSTERY IN HEPATIC GLUCOSE-6-PHOSPHATASE INFORMED BY UNSUPERVISED VARIANT EFFECT PREDICTORS. Richard A Stein, Emily Hawes, Chanel M Norphlet, Margaret H Rakonick, Shelby A. Harris, Alec S Rodriguez, Audrey M Lucerne, Valentina Rodriguez Da Silva, Derek P. Claxton Gene Expression and Regulation (Boards LB42 - LB47) L2503-Pos Board LB42 THERMODYNAMIC MODELING OF SYNTHETIC ENHANCER REVEALS THE IMPACT OF BINDING AFFINITY ON TRANSCRIPTIONAL REPRES SION. Nicholas M. Gravina , Hernan G. Garcia L2504-Pos Board LB43 STRUCTURAL PRINCIPLES OF TRANSCRIPTION COLLISIONS. John W. Watters , Andreas U. Mueller, Xiangwu Ju, Stephany J. Chuquimarca, Hannah J. Ye, Seth A. Darst, Gregory M. Alushin, Shixin Liu L2505-Pos Board LB44 THE KINETIC LANDSCAPE OF HUMAN TRANSCRIPTION FACTORS. Minghan Yang , Peter Whitney, Nicholas Mamrak, Finnegan Clark, Daniel Griffith, Alex S. Holehouse, Mikko Taipale, Timothee Lionnet L2506-Pos Board LB45 UNDERSTANDING TRANSCRIPTIONAL CONTROL BY NOTCH IN DRO SOPHILA DEVELOPMENT USING SYNTHETIC ENHANCERS. Vinayak Harihar , Bruno Moretti, Emily Dong, Shahar Kasirer, Brian Gebelein, David Sprinzak, Hernan G. Garcia L2507-Pos Board LB46 ABERRANT REGULATION OF DAPK1 EXPRESSION IN LEUKEMIA-INITIAT ING CELLS OF ACUTE MYELOID LEUKEMIA. FNU Sujata , Garima Paisal, Pradeep Kumar Rajput, Vijay P.S. Rawat L2508-Pos Board LB47 MOLECULAR EXCLUSION OF TRANSCRIPTION FACTORS FROM CHROMA TIN CONDENSATES. Job Huxford , Bryan Gibson

L2486-Pos Board LB25 COMMON CHARACTERISTICS OF VARIANTS LINKED TO AUTISM SPECTRUM DISORDER IN THE WAVE REGULATORY COMPLEX. Paolo Ruggerone , Song Xie, Ke Zuo, Giorgio Bonollo, Silvia De Rubeis, Giorgio Colombo, Paolo Carloni L2487-Pos Board LB26 STATE TRANSITIONS IN THE PHOTOPROTECTIVE ORANGE CAROTENOID PROTEINS PROBED BY MOLECULAR DYNAMICS SIMULATIONS. Christian A. Durbin , Yuxin Jiang, Josh V. Vermaas L2488-Pos Board LB27 PREDICTING PROTEIN DYNAMICS USING LARGE LANGUAGE MOD ELS. Ngoc Kim Ngan Tran , Mandy Korpusik, Zahra Alavi L2489-Pos Board LB28 POLIOVIRUS 3CD PROTEIN FLUCTUATES BETWEEN COMPACT AND EX TENDED CONFORMATIONS IN SOLUTION. Mohammad Hasan L2490-Pos Board LB29 GATE OPENING DYNAMICS OF MYCOBACTERIUM TUBERCULOSIS RNA POLYMERASE IN DNA LOADING AND ANTIBIOTIC INHIBITION REVEALED BY TS-DAR. Eshani C. Goonetilleke , Ilona Unarta, Yue Wu, Xuhui Huang L2491-Pos Board LB30 NEURO-METABOLIC MODULATION BY OXALIS CORNICULATA PHYTO COMPLEX IN ALZHEIMER’S DISEASE. Shan Lakshmanan, Arulviyabini Rajesh , Daniel Lituma-González, Tanishque Verma L2492-Pos Board LB31 UNVEILING THE FULL DYNAMICAL POTENTIAL OF A CIRCADIAN CLOCK SYSTEM BY DEEP MUTATIONAL SCANNING AND RNA SEQUENCING. Soo Ji Kim , Diane Schnitkey, Bryan Andrews, Rama Ranganathan, Michael Rust L2493-Pos Board LB32 INTERNAL PROTEIN MOTION IN INTERLEUKIN-1 CYTOKINES. Glorise Torres Montalvo , Anthony Bishop, Joshua Wand, Taylor Cole L2494-Pos Board LB33 RAPID IN VITRO CHARACTERIZATION OF PKA SIGNAL TERMINATION REVEALS ACCELERATED SIGNAL TERMINATION IN ACRODYSOSTOSIS MUTATIONS. Connor Cronin , Christopher J. Obara, Susan S. Taylor L2495-Pos Board LB34 INTRINSIC DYNAMICS OF ARRESTIN PROTEINS ARE CRITICAL FOR GPCR ARRESTIN COMPLEX ASSEMBLY. Jesse Hudspeth, Jonathan Deutsch, Rabindra V. Shivnaraine, Brian K. Kobilka, David Jones, Elan EISENMESS ER, John Janetzko L2496-Pos Board LB35 CONFORMATIONAL SHIFTS IN THE INSULIN RECEPTOR ECTODOMAIN BETWEEN APO AND BOUND STATES. Anton Andricioaei Membrane Protein Folding (Boards LB36 - LB36) L2497-Pos Board LB36 FROM SEQUENCE TO ASSAY-READY GPCRS IN 48 HOURS USING CELL FREE MULTIPLEX SCREENING. Aujan Mehregan

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