Biophysical Newsletter - March 2014

3

BIOPHYSICAL SOCIETY NEWSLETTER

2014

MARCH

Following his postdoc position, Matulis found work as a research scientist with 3-Dimensional Pharmaceuticals (3-DP), a mid-sized company later acquired by Johnson & Johnson. Matulis says, “I am grateful for my years in industry, where I got not only significant experience in drug design, but also the vision that all research is for the better understanding and better application to practice.” His experience working in industry served to enrich his scientific viewpoint and repertoire, but upon re- turning to Lithuania, he also returned to academia. In his current position as Head of the Department of Biothermodynamics and Drug Design at the In- stitute of Biotechnology, Vilnius University, Matu- lis oversees about 40 researchers and students. The goal in assembling this team was to bring together scientists from a variety of fields: organic synthesis, target protein recombinant production in bacte- rial and human cells, computational molecular modeling to benefit synthesis efforts, protein- ligand binding biophysics, x-ray crystallography, pharmacy, and immunology. As Matulis had experienced in his previous positions, this variety of viewpoints and foci has led to stimulating science. He explains, “I believe that most new and exciting science is born at the interface between these fields. We have designed over 550 ligands that specifi- cally bind carbonic anhydrase (CA), a well-studied enzyme that has twelve isoforms in humans and has been implicated in various diseases such as can- cer, glaucoma, epilepsy, and obesity, to mention a few.” The laboratory hopes eventually to publish a database of the x-ray crystal structures that are correlated to the measurements of intrinsic binding thermodynamics to all twelve CA isoforms. In addition to his science, Matulis offers the lab his talent at bringing out the best in those around him. Joana Gylytė , his student of four years, says, “Dr. Matulis is a true leader who takes care of every group member and inspires others to do their best. He is eager to share his experience and encourages everybody to realize their ideas.” For his part, Matulis finds seeing his students’ progress to be one of the most rewarding aspects of his work as a biophysicist. While Matulis’s research and mentoring are fulfilling to him, his career certainly has presented

him with challenges as well. His time training and working in the US was valuable, but he explains, “Going to the USA was easier than to return and produce decent science that could be of interest in the USA.” Additionally, maintaining a professional network with scientists in the US has been difficult after returning to Lithuania. “The Biophysical Society takes a very special place in my life,” Matulis says, “It is one of the main remaining connections with the US scientists.” Matulis has been working at establishing connections closer to home, too. In 2012, he hosted a successful networking event with the help of a Biophysical Society mini-grant. Over thirty biophysicists working in Lithuania met to discuss their research and the future of the biophysics community within the country, and in the context of the larger European community. Matulis’s scientific activities outside of the lab have not gone unnoticed—or unappreciated. Osvaldas Rukšėnas , Dean of the Faculty of Natural Sciences at Vilnius University, says of Matulis, “What I like in him is that in addi- tion to being a high level scientist, he is very active in science policy activities. He doesn’t close himself in the laboratory.” When he is not working on his research or on science policy, Matulis enjoys exercise (especially field tennis); reading about politics, history, and geography; and traveling. More important than these pursuits is the time he spends with his family, which includes his four children, and his wife, Jurgita Matulienė , who received her PhD in cell biology from the University of Min- nesota in 2003, and returned to Lithuania with Matulis to conduct her research. For those considering careers in biophysics, Matulis would encourage them to continue on their path, wherever they may be coming from: “I believe that there could be very many different paths to biophysics, and therefore there could be no best advice. However, I feel that the overall field of deep molecular understanding of cellular phenomena where weak non-covalent forces are involved will give us great challenges for many years….the choice to be a researcher in biophysics is the right one.”

Daumantas Matulis with Rex Lovrien (left) at the confluence of Mississippi and Ohio rivers after a Gibbs Conference in Carbondale, Illinois, in 2001.

Matulis on vacation with his family (wife, Jurgita Matulien and their four children, from oldest: Eimantas, Renata, Vaigintas, and the little Tautvydas) at Druskininkai Resort in Lithuania in 2012.