Biophysical Society 2020 Annual Meeting

984-Pos Board B52 CONTINUOUS, TOPOLOGICALLY GUIDED PROTEIN CRYSTALLIZATION DRIVES SELF-ASSEMBLY OF A BACTERIAL SURFACE LAYER.  Colin J. Comerci , Jonathan Herrmann, Joshua Yoon, Fatemeh Jabbarpour, Xiaofeng Zhou, John F. Nomellini, John Smit, Lucy Shapiro, Soichi Wakat- suki, William E. Moerner 985-Pos Board B53 AFFINITY BETWEEN MACROMOLECULAR REGULATORS LEADS TO PRECISE CONTROL OF LIQUID-LIQUID PHASE SEPARATION.  Konstantinos P. Mazarakos , Archishman Ghosh, Xiaojia Zhang, Valery Nguemaha, Huan-Xiang Zhou 986-Pos Board B54 STRUCTURAL AND CONFORMATIONAL CHANGES IN AMYLOID BETA PEP- TIDES INDUCED BY THE PRESENCE OF SURFACTANTS.  Michalina M. Wilkowska , Aneta Szymanska, Barbara Peplińska, Marek Kempka, Monika Makrocka-Rydzyk, Maciej L. Kozak 987-Pos Board B55 MOLECULAR MECHANISMS OF RNA SENSING IN NLRP6 INFLAMMASOME SIGNALING. Chen Shen , Runzhi Li, Roberto Negro, Richard Flavell, Shu Zhu, Hao Wu 988-Pos Board B56 QUANTIFYING PROTEIN-PROTEIN BINDING INTERACTION IN VITRO AND IN CELLS. Yuhan Wang , Mahima Unnikrishnan, Brooke Ramsey, Martin Gruebele 989-Pos Board B57 INFLUENCE OF IONIC AQUEOUS SOLUTION ON THE AΒ 16-22 SELF-ASSEM- BLY: A REPLICA-EXCHANGE MOLECULAR DYNAMICS STUDY. Zhenyu Qian , Lili Zhu, Zhiwei Liu 990-Pos Board B58 TWO CALCIUM SENSORS, ONE TARGET: PRP40 INTERACTS WITH CALMODULIN AND CENTRIN. Adalberto Diaz-Casas , Walter J. Chazin 991-Pos Board B59 ATP REGULATED TIME WINDOW TRIGGERED BY CA 2+ /CAM FOR GATING CAMKII HOLOENZYME INTERACTIONS WITH NR2B. Tuan A. Nguyen , Henry L. Puhl, Daniel Liput, Grace H. Taumoefolau, Steven S. Vogel, Youngchan Kim 992-Pos Board B60 MOLECULAR MECHANISMS FOR THE STOCHASTIC CONDENSATION OF LAT ASSEMBLIES IN T CELLS. Mark K. ODair , Darren B. McAffee, Jay T. Groves 993-Pos Board B61 ROBUST MODULATION OF A BACTERIAL KINASE BY PROTEIN PHASE SEPARATION. Saumya Saurabh , Trisha Chong, Camille Bayas, Peter D. Dahlberg, William E. Moerner, Lucy Shapiro 994-Pos Board B62 SEGMENTAL AGGREGATION AND STRUCTURAL PROPENSITIES OF AMY- LOID BETA PEPTIDE. Faisal Abedin , Nabin Kandel, Suren A. Tatulian 995-Pos Board B63 STRUCTURE AND AGGREGATION OF ABETA 1-40 AND PYROGLUTAMYLATED ABETA 3-40 SEPARATELY AND COMBINED. Faisal Abedin , Suren A. Tatulian 996-Pos Board B64 ASSEMBLY OF I-BAR CONTAINING PROTEIN IRSP53 ENHANCES MEM- BRANE BENDING. Kristin D. Graham , Wilton T. Snead, Liping Wang, Eileen M. Lafer, Jeanne C. Stachowiak 997-Pos Board B65 STRUCTURAL BASIS OF CURVATURE GENERATION BY DYNAMIN-RELATED PROTEIN 1. Paul V. Thomas

998-Pos Board B66 NUCLEIC ACID-INDUCED DIMERIZATION OF HIV-1 GAG PROTEIN.  Huaying Zhao , Siddhartha A. Datta, Sung Kim, Samuel To, Sumit K. Chaturvedi, Alan Rein, Peter Schuck 999-Pos Board B67 Travel Awardee STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF SPLICING-AS- SOCIATED ASSEMBLIES OF THE SMN PROTEIN. Kaylee L. Mathews , Jacob Marglous, Nicolas L. Fawzi Protein Dynamics and Allostery II (Boards B68 - B87) 1000-Pos Board B68 WHAT ARE THE DESIGN PRINCIPLES FOR EVOLUTION FROM PROMISCU- OUS TO SUBSTRATE SPECIFICITY? Tushar Modi , Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, S. Banu Ozkan 1001-Pos Board B69 LARGE SCALE DISEASE SUSCEPTIBILITY PREDICTION OF NSNVS BY DY- NAMICS INFORMATION BASED NEURAL NETWORKS.  Ismail C. Kazan , S. Banu Ozkan 1002-Pos Board B70 MARKOV STATE MODEL APPROACH TO ESTIMATING RATES AND MECHA- NISMS OF VSL12 PEPTIDE TO SRC-FAMILY KINASE SH3 DOMAINS.  Robert Raddi , Vincent Voelz 1003-Pos Board B71 MOLECULAR DYNAMICS OF VILLIN HEADPIECE-36 UNDER DIFFERENT HYDRATION LEVELS.  Jillian Oviedo 1004-Pos Board B72 EXPLAINABLE MACHINE LEARNING FRAMEWORK TO PREDICT FUNC- TIONAL EFFECTS OF PROTEIN MUTATIONS FROM ALTERATIONS IN STRUC- TURAL DYNAMICS. Sunaina Banerjee , Sumanta Mukherjee, Rahul Roy 1005-Pos Board B73 FAST CONFORMATIONAL SEARCHES TO CHARACTERIZE THE EFFECTS OF MUTATIONS ON COMPLEX LANDSCAPES. Maxwell I. Zimmerman , Gregory Bowman 1006-Pos Board B74 ASYMMETRIC ATP HYDROLYSIS KINETICS OF ABCE1 EXPLAINED WITH A MARKOV STATE MODEL. Malte Schäffner , Nicholas Leioatts, Colin A. Smith, Hadas Leonov, Bert L. de Groot, Helmut Grubmueller 1007-Pos Board B75 INVESTIGATION OF ALLOSTERIC INHIBITION MECHANISMS BY THE PEP- TIDE P5 ON THE ALZHEIMER’S DISEASE (AD) PATHOLOGICAL COMPLEX CDK5-P25 THROUGH MOLECULAR DYNAMICS SIMULATIONS.  Tejaswi Tammareddy , Antonio Cardone, Sergio Hassan, Harish Pant, Mary Brady, Ram Sriram, Jeffery B. Klauda 1008-Pos Board B76 DYNAMIC ORGANIZATION IN THE SUPERTERTIARY STRUCTURE OF PDZ3- SH3-GUK CORE SUPRAMODULE OF PSD-95 SCAFFOLD PROTEIN.  Nabanita Saikia , George L. Hamilton, Hugo Sanabria, Mark E. Bowen, Board B77 COMPUTATIONAL MODELING AND ENGINEERING OF ALLOSTERIC REGULATORY MECHANISMS IN SIGNALING PROTEINS: INTEGRATION OF MULTISCALE SIMULATIONS, NETWORK BIOLOGY AND MACHINE LEARN- ING. Gennady Verkhivker 1010-Pos Board B78 MOLECULAR DYNAMICS SIMULATION REVEALS NEW POCKET FOR THE DESIGN OF NOVEL AMINO ACID COUPLED SIRT1 SELECTIVE INHIBI- TOR. Mrityunjay Singh , Mitul Srivastava, Nikil Purushotham, Bugga Paramesha, Sharad R. Wakode, Boja Poojary, Sanjay K. Banerjee, Shailen- dra Asthana Feng Ding 1009-Pos

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