Biophysical Society 2020 Annual Meeting

1037-Pos Board B105 MOLECULAR MECHANISMS OF AUTOINHIBITION AND ACTIVATION OF THE EUKARYOTIC LIPID FLIPPASE DRS2P-CDC50P. Lin Bai, Huilin Li 1038-Pos Board B106 Travel Awardee RESOLVING CD47 STRUCTURE AND FUNCTION TO UNDERSTAND SIGNAL TRANSDUCTION MECHANISM. Sarah M. Young , Tarjani M. Thaker, Thomas M. Tomasiak, William R. Montfort 1039-Pos Board B107 MAPPING THE ATP HYDROLYSIS CYCLE OF A CLOSTRIDIUM PERFRINGENS ABC TRANSPORTER. Sergei Pourmal Intrinsically Disordered Proteins (IDP) and Aggregates II (Boards B108 - B131) 1040-Pos Board B108 LIQUID-LIQUID PHASE SEPARATION OF INTRINSICALLY DISORDERED PROTEINS FOR DEVELOPMENT OF MEMBRANELESS ORGANELLES IN SYNTHETIC CELLS. Michele Costantino , Prerna Sharma, Sara M. Vaiana, Giovanna Ghirlanda 1041-Pos Board B109 MULTIDIMENSIONAL PHASE DIAGRAMS FOR MULTICOMPONENT SYS- TEMS COMPRISING MULTIVALENT PROTEINS. Furqan Dar , Rohit V. Pappu 1042-Pos Board B110 CONFORMATIONAL FLEXIBILITY OF P53 TRANSACTIVATION DOMAIN CONTROLS DNA BINDING SPECIFICITY AND PROMOTER SELECTIV- ITY. Emily Gregory-Lott , Wade M. Borcherds, Fan He, Mi Zhou, Gary W. Board B111 SECONDARY STRUCTURE PREDICTION FOR INTRINSICALLY DISORDERED PROTEINS. Youngchan Kim , Nina Jovic, Jeetain Mittal 1044-Pos Board B112 IMPACT OF HYDROPHOBIC PATTERNING ON CONFORMATIONAL EN- SEMBLE OF DISORDERED PROTEINS. Wenwei Zheng , Gregory Dignon, Matthew Brown, Jeetain Mittal 1045-Pos Board B113 NANO-DROPLET OLIGOMERS (NANDOS) OF AMYLOID-BETA 40.  Jay M. Pittman , Atul K. Srivastava, Christopher T. Boughter, Bharat Somireddy Venkata, Jonathan Zerweck, Patrick C. Moore, Joseph R. Sachleben, Stephen C. Meredith 1046-Pos Board B114 COMPACT DISORDER OF ESTROGEN RECEPTOR. Sichun Yang 1047-Pos Board B115 NANOPORES TO INTERROGATE THE CONFORMATIONAL ENSEMBLES OF INTRINSICALLY DISORDERED PROTEINS ON A SINGLE-MOLECULE LEVEL. Saurabh Awasthi , Jared Houghtaling, Cuifeng Ying, Aziz Fennouri, Ivan Shorubalko, Michel Calame, Mitu C. Acharjee, Jiali Li, Michael Mayer 1048-Pos Board B116 TUNING THE ACTIVITY OF DISORDERED PROTEINS BY CHANGING SOLU- TION CONDITIONS. David Moses, Feng Yu, Alex S. Holehouse, Shahar Sukenik 1049-Pos Board B117 MOLECULAR MECHANISMS OF LOW COMPLEXITY SEQUENCE PROTEIN ASSEMBLY. Yuuki Wittmer, Blake Fonda, Rachelle Stowell, Natalie Boulos, Rebecca Rafique, Rong Hu, Truc Le, Dylan T. Murray 1050-Pos Board B118 PROTEIN DISORDER REGULATES THE DNA BINDING SPECIFICITY OF P53. Robin Levy , Wade M. Borcherds, Fan He, Gary W. Daughdrill, Jian- dong Chen Daughdrill 1043-Pos

1051-Pos Board B119 DISEASE ASSOCIATED MUTATIONS IN INTRINSICALLY DISORDERED PRO- TEINS SHOW EVIDENCE OF ENRICHMENT IN HYDROPHOBIC BLOBS. Ruchi Lohia , Kaitlin Bassi, Matthew Hansen, Grace Brannigan 1052-Pos Board B120 THERMODYNAMICS OF THE INTERACTION BETWEEN BIOLOGICAL POLY- ELECTROLYTE-LIKE DISORDERED PROTEINS: FROM BINARY COMPLEXES TO OLIGOMERS. Aritra Chowdhury , Andrea Sottini, Alessandro Borgia, Madeleine B. Borgia, Daniel Nettels, Benjamin Schuler 1053-Pos Board B121 MOLTEN GLOBULE DRIVEN LIQUID-LIQUID PHASE SEPARATION AT THE CENTER OF VIRAL FACTORY ASSEMBLY. Mariano Salgueiro, Gabriela Camporeale, Julieta Conci, Belen Sousa, Araceli Visentin, Agustin Corbat, Hernan Grecco, Guilherme A. de Oliveira, Gonzalo de Prat-Gay 1054-Pos Board B122 THE IMPROVED ABILITY OF APOA-I AMYLOIDOGENIC VARIANTS AT MEDI- ATING CHOLESTEROL EFFLUX RELIES ON THEIR INCREASED STRUCTURAL FLEXIBILITY.  Jens O. Lagerstedt , Oktawia Nilsson, Mikaela Lindvall, Laura Obici, Simon Ekström, Rita Del Giudice 1055-Pos Board B123 WATER DYNAMICS AND INTERACTIONS INSIDE AMYLOID-BETA FI- BRILS. Sachin Natesh, Alex R. Hummels , Joseph R. Sachleben, Tobin R. Sosnick, Karl F. Freed, Stephen C. Meredith, Esmael J. Haddadian 1056-Pos Board B124 STRUCTURAL CHARACTERIZATION OF HUNTINGTIN: MECHANISM OF AG- GREGATION AND DISAGGREGATION. Silvia A. Cervantes Cortes , J. Mario Isas, Janine Kirstein, Ralf Langen, Ansgar B. Siemer 1057-Pos Board B125 CARDIOLIPIN MODULATES HUNTINGTIN AGGREGATION AND BIND- ING TO MITOCHONDRIAL MEMBRANES. Adewale Adegbuyiro , Faezeh Sedighi, Justin Legleiter 1058-Pos Board B126 TRANSIENT STRUCTURE FORMATION KINETICS OF MONOMERIC ALPHA- SYNUCLEIN DERIVED FROMMD SIMULATIONS. Reinhard Klement , Timo Graen, Asaf Grupi, Elisha Haas, Helmut Grubmueller 1059-Pos Board B127 ALL-ATOMMOLECULAR DYNAMICS SIMULATION OF THE ALTERED PROTEIN-PROTEIN INTERACTION WITH METABOLITES AND IONS IN THE CYTOPLASM.  Isseki Yu , Michael Feig, Yuji Sugita 1060-Pos Board B128 TRACKING OLIGOMERIZATION OF ALPHA-SYNUCLEIN DEMONSTRATES PIVOTAL ROLE OF MITOCHONDRIA IN SEEDING. Minee L. Choi , Mathew H. Horrocks, Margarida Rodrigues, Suman De, Laura Tosatto, Weilia Zhang, Gurvir Virdi, David Klenerman, Andrey Y. Abramov, Sonia Gandhi 1061-Pos Board B129 INTEGRATIVE SEQUENCE-BASED CLASSIFICATION OF INTRINSICALLY DISORDERED REGIONS. Garrett M. Ginell , Jared Lalmansingh, Megan C. Cohan, Alex S. Holehouse 1062-Pos Board B130 IDENTIFICATION OF STRUCTURAL DEFECTS IN AMYLOID BETA FIBRIL AS POTENTIAL SITES FOR INHIBITION OF PROTEIN AGGREGATION.  Giuseppe Licari , Soumyo Sen, Xing Jiang, Jeffrey S. Moore, Emad Tajkhor- shid 1063-Pos Board B131 CHARACTERIZATION OF SMALL OBJECTS IN HOMOGENATES OF THE SQUID OPTIC LOBE. Catherine Chang , Amelia Ralowicz, Yuto Kegawa, Jen- nifer Petersen, Gulcin Pekkurnaz, Paul S. Blank, Joshua Zimmerberg

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