Biophysical Society 2020 Annual Meeting

Optical Microscopy and Superresolution Imaging II (Boards B569 - B603) 1501-Pos Board B569 Travel Awardee DEVELOPMENT OF A SINGLE-CELL LABEL-FREE DRUG TESTING PLATFORM USING FLUORESCENCE LIFETIME IMAGING MICROSCOPY (FLIM) FOR PATIENTS WITH METASTATIC CANCER. Ning Ma 1502-Pos Board B570 PHASOR-FLIM QUANTIFICATION OF CHANGES IN KERATINOCYTE ME- TABOLISM AND TISSUE ARCHITECTURE IN A LONGITUDINAL STUDY OF UV-INDUCED SKIN CANCER. Michael G. Nichols , Molly Myers, Dominick Myers, Kelsey A. Jackson, Ben G. Huerter, Duyen Nguyen, Connor J. Kalhorn, George Varghese, Katie D. Sotelo, Marifel Frances Gabriel, Dan L. Che, Emiliano Altuzar, Anya Long, Jackson W. Morris, Laura A. Hansen 1503-Pos Board B571 MAPPING THE SPATIOTEMPORAL HETEROGENEITY OF BIOMOLECULES CONCENTRATION, MOBILITY AND LOCAL ENVIRONMENT IN LIVE CELLS USING QUANTITATIVE TIME-RESOLVED CONFOCAL FLUORESCENCE MICROSCOPY IMAGING WITHOUT SCANNING AND FLUORESCENCE LIFETIME IMAGING MICROSCOPY. Sho Oasa , Aleksandar Krmpot, Stanko Nikolic, Lars Terenius, Rudolf Rigler, Vladana Vukojevic 1504-Pos Board B572 AO-DIVER ADVANCES THE DEPTH LIMITS OF MULTIPHOTON MICROS- COPY IN SCATTERING MEDIA. Simon W. Leemans , Alexander Dvornikov, Tara Gallagher, Enrico Gratton 1505-Pos Board B573 NON-DESTRUCTIVELY ANALYZING THE METABOLIC DYSREGULATION OF INVASIVE CANCER CELLS ON AN INTRACELLULAR SCALE. Austin E.Y.T. Lefebvre , Freddie A. Adame, Mingjuan Liu, Michelle A. Digman 1506-Pos Board B574 TCSPC CAMERA FOR REAL TIME VIDEO RATE FLIM ACQUISITION BASED ON CMOS TECHNOLOGY. Graham Hungerford , David McLoskey, Richard Hirsch, Philip Yip, David J. Birch, Nick Johnston, Robert K. Henderson 1507-Pos Board B575 SINGLE-OBJECTIVE MULTIPHOTON LIGHT-SHEET MICROSCOPY FOR LUNG CANCER ORGANOID SCREENING. Trung D. Nguyen , Yen-Liang Liu, Dat Nguyen, Yuan-I Chen, Yu-An Kuo, SoonWoo Hong, Andrew K. Dunn, Tim Yeh 1508-Pos Board B576 MEASURING THE SPATIAL DISTRIBUTION OF DIPOLAR RELAXATION IN LIVE ZEBRAFISH EYE LENSES DURING DEVELOPMENT.  Alexander Vallmitjana , Irene Vorontsova, Belén Torrado, Thomas F. Schil- ling, James E. Hall, Enrico Gratton, Leonel S. Malacrida 1509-Pos Board B577 WATER DYNAMICS OF A MODEL PROTEIN PHASE SEPARATION VIA FLUO- RESCENCE LIFETIME AND SPECTRAL ANALYSIS OF ACDAN.  Francesco Palomba , Lorenzo Scipioni, Enrico Gratton, Michelle A. Digman 1510-Pos Board B578 CADHERIN ORGANIZATION IN DESMOSOMES PROBED USING FLUORES- CENCE POLARIZATION MICROSCOPY. William F. Dean , Emily I. Bartle, Alexa L. Mattheyses 1511-Pos Board B579 ACCURATE FLUORESCENCE FLUCTUATION ANALYSIS OF DIFFUSING PROTEINS IN LIVING CELLS WITH TIME-SHIFTED SEGMENTED Q ANALY- SIS.  John Kohler , Kwang Ho Hur, Jared Hennen, Joachim D. Mueller 1512-Pos Board B580 OBSERVATION OF TORSINA POLYMERIZATION AT THE NUCLEAR ENVE- LOPE BY QUANTITATIVE PHOTOBLEACHING AND FLUORESCENCE FLUC- TUATION ANALYSIS. Kwang Ho Hur , Jared Hennen, Amy Schoenhofen, GW Gant Luxton, Joachim D. Mueller

1486-Pos Board B554 SAMPLING SOLVATION FREE ENERGY OF ELECTROLYTIC SOLVENTS WITH 3D2PT. Edgar Manriquez-Sandoval 1487-Pos Board B555 HYBRID QUANTUMMECHANICS/ROSETTA MODELING MECHANISTIC STUDY OF A TERPENE SYNTHASE. Sophie R. Shoemaker , Yue Zhang, Ter- rence O’Brien, Dean Tantillo, Justin B. Siegel 1488-Pos Board B556 REPLICA-PERMUTATION METHODS IN ISOTHERMAL-ISOBARIC ENSEMBLE AND THEIR APPLICATIONS TO INVESTIGATE PROTEIN STABILITY UNDER HIGH-PRESSURE CONDITIONS. Masataka Yamauchi , Hisashi Okumura 1489-Pos Board B557 COMBINED THEORETICAL AND COMPUTATIONAL APPROACH FOR CAL- CULATING SEQUENCE-SPECIFIC PHASE DIAGRAMS OF THERMORESPON- SIVE INTRINSICALLY DISORDERED HOMOPOLYPEPTIDES. Xiangze Zeng , Rohit V. Pappu 1490-Pos Board B558 MATHEMATICALLY MODELING MECHANISMS OF MOLECULAR IDENTITY IN BIOMOLECULAR CONDENSATES. Kelsey Gasior , M. Greg Forest, Amy S. Gladfelter, Jay Newby 1491-Pos Board B559 ELECTROPHORETIC TRAPPING OF A SINGLE PROTEIN INSIDE A NANO- PORE. KherimWillems , Dino Ruić, Annemie Biesemans, Nicole Galen- kamp, Pol Van Dorpe, Giovanni Maglia 1492-Pos Board B560 INTERACTION ANALYSIS BETWEEN HIV GP120 AND THE ANTIBODIES BY FRAGMENT MOLECULAR ORBITAL METHOD. Norihito Kawashita 1493-Pos Board B561 RANKING OF LIGAND BINDING KINETICS USING A WEIGHTED ENSEMBLE APPROACH AND COMPARISON WITH MILESTONING. Surl-Hee Ahn , Ben- jamin Jagger, Rommie E. Amaro 1494-Pos Board B562 STOCHASTIC SIMULATION OF CLOSE-CONTACT DYNAMICS IN IMMUNE RECOGNITION.  Jonathan M. Morgan , Alan Lindsay, Omer Dushek, Jo- hannes Pettmann 1495-Pos Board B563 LASSA VIRUS EPITOPE-ALLELE COMPLEXES IDENTIFIED THROUGH COMPUTATIONAL MODELING. Prabin Baral , Elumalai Pavadai, Bernard Gerstman, Prem P. Chapagain 1496-Pos Board B564 Travel Awardee COMPUTER VISION FOR PROTEIN-PROTEIN DOCKING. Lucas S.P. Rudden , Matteo T. Degiacomi, Chris G. Willcocks 1497-Pos Board B565 DOCKING DECOYS FOR MODELED PROTEINS.  Ian P. Kotthoff , Petras J. Kundrotas, Ilya A. Vakser 1498-Pos Board B566 Travel Awardee DYNAMICAL METRICS TO FINGERPRINT PROTEINS AND PROTEIN-PRO- TEIN INTERACTIONS. Sanjoy Paul , Ravindra Venkatramani 1499-Pos Board B567 ALGORITHMS FOR PARAMETERIZING NETWORK HAMILTONIANS FOR SIMULATIONS OF AMYLOID FIBRIL SELF-ASSEMBLY. Gianmarc Grazioli , Yue Yu, Megha H. Unhelkar, Rachel W. Martin, Carter T. Butts 1500-Pos Board B568 PHYSICO-CHEMICAL PROPERTIES OF THE STRONG TOBACCO SMOKE CARCINOGEN NNK DIAZONIUM ION. Christos Deligkaris , Evan Millam, David Wahl

M O N D A Y

95