Biophysical Society 2020 Annual Meeting

Platform Protein-Lipid Interactions II 1:00 pm - 3:00 pm, Room 25ABC

2441-Plat 1:30 pm DIFFERENTIAL MODULATION OF L-TYPE CA V Angelini, Alan Neely, Riccardo Olcese 2442-Plat 1:45 pm BY THE Α 2

1.1 AND CA V

1.2 CHANNELS

Δ-1 SUBUNIT.  Federica Steccanella , Nicoletta Savalli, Marina

W E

Co-Chairs Constance Agamasu, Frederick National Laboratory for Cancer Research Alemayehu Gorfe, University of Texas Health Science Center at Houston 2431-Plat 1:00 pm EMERGING INSIGHTS INTO THE MEMBRANE BINDING DOMAIN OF RAF ENGAGING WITH THE PLASMA MEMBRANE AND ITS IMPLICATION ON RAF ACTIVATION.  Constance Agamasu , De Chen, John Columbus, Frank Heinrich, Marco Tonelli, Christopher B. Stanley, Thomas Turbyville, Frank McCormick, Dwight V. Nissley, Andrew G. Stephen 2432-Plat 1:15 pm DHHC20 PALMITOYL-TRANSFERASE RESHAPES THE MEMBRANE TO FOSTER CATALYSIS.  Robyn Stix , James Song, Anirban Banerjee, José D. Faraldo- Gómez 2433-Plat 1:30 pm USING MACHINE LEARNING TO PREDICT MEMBRANE PROTEIN STATES BASED ON THEIR LIPID ENVIRONMENT.  Adam T. Moody, Gautham Dharu- man, Timothy S. Carpenter , Helgi I. Ingolfsson, Brian C. Van Essen, James N. Glosli, Felice C. Lightstone 2434-Plat 1:45 pm STATE-DEPENDENT AND MUTATION-INDUCED DIFFERENCES IN PROTEIN- LIPID INTERACTIONS IN THE NA,K ATPASE.  Dhani R. Mahato , Magnus 2:00 pm Travel Awardee VISUALIZATION OF PROTEIN-LIPID INTERACTIONS IN CONNEXIN-46/50 INTERCELLULAR CHANNELS BY CRYO-EM AND MD-SIMULATION.  Bassam G. Haddad , Jonathan A. Flores, Kimberly A. Dolan, Janette B. Myers, Craig C. Yoshioka, Daniel M. Zuckerman, Steve L. Reichow 2436-Plat 2:15 pm CRYO-EM STRUCTURES OF THE GIRK2 CHANNEL REVEAL MECHANISMS FOR LIPID MODULATION.  Ian W. Glaaser , Yamuna K. Mathiharan, Yulin Zhao, Georgios Skiniotis, Paul A. Slesinger 2437-Plat 2:30 pm CRYSTAL STRUCTURE OF MID51 BOUND TO PHOSPHOLIPID.  Nikhil Bharambe 2438-Plat 2:45 pm DYNAMICS OF ONCOGENIC KRAS MUTANTS ON BILAYER SURFACES.  Pri- yanka Prakash Srivastava, Douglas B. Litwin, Liang Hong, Suparna Sarkar-Ba- nerjee, DrewM. Dolino, Yong Zhou, Vasanthi Jayaraman, John F. Hancock, Alemayehu A. Gorfe Platform Voltage-gated Na and Ca Channels 1:00 pm - 3:00 pm, Room 30ABC Co-Chairs Han Chow Chua, University of Copenhagen, Denmark Ivy Dick, University of Maryland 2439-Plat 1:00 pm WHICH CAV1.1 VOLTAGE SENSOR(S) ACTIVATE RYR1? Marina Angelini , Ni- coletta Savalli, Federica Steccanella, Marino G. Di Franco, Alan Neely, Steve C. Cannon, Riccardo Olcese 2440-Plat 1:15 pm TOWARDS A DEEPER UNDERSTANDING OF THE DIVERSE ROLES OF THE CA V 1.2 S6. Moradeke A. Bamgboye , Josiah O. Owoyemi, Kevin G. Herold, Maria K. Traficante, Ivy E. Dick Andersson 2435-Plat

HUMAN CARDIAC VOLTAGE-GATED CALCIUM CHANNEL PHOSPHORYLA- TION BY CAMP-DEPENDENT PROTEIN KINASE A.  Omid Haji-Ghassemi , Jiaming Xu, Filip Van Petegem 2443-Plat 2:00 pm Travel Awardee THE SODIUM LEAK CHANNEL COMPLEX IS MODULATED BY VOLTAGE AND EXTRACELLULAR CALCIUM.  Han Chow Chua , Matthias Wulf, Claudia Weidling, Lise Pilgaard Rasmussen, Stephan A. Pless 2444-Plat 2:15 pm MECHANISM OF SODIUM CHANNEL INHIBITION BY CANNABIDIOL.  Mohammad-Reza Ghovanloo , Tagore Sanketh Bandaru, Koushik Choud- hury, Mohamed Fouda, Kaveh Rayani, Damon Poburko, Lucie Delemotte, Peter C. Ruben 2445-Plat 2:30 pm TARGETING OF NAV1.6 AND NAV1.2 TO INHIBIT EXCITATORY VS INHIBITO- RY NEURAL CIRCUITS.  Samuel J. Goodchild , Mohammad-Reza Ghovan- loo, Aaron Williams, Noah Shuart, Maegan Soriano, Janette Mezeyova, Richard Dean, Thilo Focken, Peter Ruben, James Empfield, Charles Cohen, J.p. Johnson 2446-Plat 2:45 pm COMPARATIVE STUDY OF THE EFFECTS OF AN SCN5A MUTATION WITHIN A FAMILY DIAGNOSED WITH BRUGADA SYNDROME USING IPS-CM.  Rebecca Martinez-Moreno , David Carreras, Elisabet Selga, Georgia Sarquella-Brugada, Ramon Brugada, Guillermo J. Perez, Fabiana S. Scornik Platform Protein Structure and Conformation IV 1:00 pm - 3:00 pm, Room 31ABC Co-Chairs Wei Liu, University of Science and Technology of China, China Marc Ruff, IGBMC, CERBM, France 2447-Plat 1:00 pm PATHOGENIC SIDEROPHORE ABC IMPORTER YBTPQ ADOPTS A SURPRIS- ING FOLD OF EXPORTER.  Zhiming Wang , Wenxin Hu, Hongjin Zheng 2448-Plat 1:15 pm ATOMIC STRUCTURE OF THE HUMAN HERPESVIRUS 6B CAPSID AND CAP- SID-ASSOCIATED TEGUMENT COMPLEXES. Wei Liu , Yibo Zhang, Zihang Li, Vinay Kumar, Ana L. Alvarez-Cabrera, Emily C. Leibovitch, Yanxiang Cui, Ye Mei, Guo-Qiang Bi, Steve Jacobson, Z. Hong Zhou 2449-Plat 1:30 pm HIV-1 PRE-INTEGRATION COMPLEXES. STRUCTURES, FUNCTIONS AND DRUG DESIGN.  Julien Batisse, Eduardo Bruch, Nicolas Levy, Sylvia Eiler, Sylvie Duclaud, Patrick Schultz, Patrice Gouet, Serge Bouaziz, Olivier Dele- lis, Vincent Parissi, Marc Ruff 2450-Plat 1:45 pm PROTEASOME CONFORMATIONAL REGULATION OF SUBSTRATE ENGAGE- MENT AND DEGRADATION.  Eric R. Greene , Ellen Goodall, Andres H. de la Peña, Mary Matyskiela, Gabriel Lander, Andreas Martin 2451-Plat 2:00 pm A STRUCTURAL AND MECHANISTIC MODEL FOR THE INTERACTION OF PARKINSON’S DISEASE-RELATED LRRK2 WITH MICROTUBULES.  Colin K. Deniston , Andres Leschziner, John Salogiannis, David Snead, Indrajit Lahiri

D N

E S

D A Y

143