Biophysical Society 2020 Annual Meeting

2590-Pos

Board B136

2602-Pos Travel Awardee LIGAND BINDING STUDIES OF A TRIMETHOPRIM-RESISTANT DIHYDROFO- LATE REDUCTASE BY FLUORINE NMR. Gabriel J. Fuente Gomez , Michael Duff, Elizabeth Howell 2603-Pos Board B149 THE DISSOCIATION MECHANISM OF THE PROCESSIVE CELLULASE TR CE- L7A.  Josh V. Vermaas , Riin Kont, Gregg T. Beckham, Michael F. Crowley, Mikael Gudmundsson, Mats Sandgren, Jerry Ståhlberg, Priit Väljamäe, Brandon C. Knott 2604-Pos Board B150 EFFECT OF BINDING SITE MUTATIONS IN FIBRINOGEN ΑC (233-425) ON FXIII SUBSTRATE SPECIFICITY. Francis Dean O. Ablan , Nicholas M. McCann, Mohammed M. Hindi, Muriel C. Maurer 2605-Pos Board B151 EFFECT OF CARGO IDENTITY ON ACYL CARRIER PROTEIN STRUCTURE. Terra Sztain-Pedone , Michael D. Burkart, James A. McCammon 2606-Pos Board B152 ENZYME ACTIVATION MECHANISM OF COCOONASE. Mai Takegawa , Tsubasa Tagawa, Ayumi Ogata, Shigeru Shimamoto, Yuji Hidaka 2607-Pos Board B153 STRUCTURAL AND FUNCTIONAL STUDIES OF HUMAN TYPE II TOPOISOM- ERASES AND THEIR POST-TRANSLATIONAL MODIFICATIONS.  Christophe Lotz , Claire Bedez, Claire Batisse, Arnaud Vanden Broeck, Rob- ert Drillien, Marc Ruff, Valérie Lamour 2608-Pos Board B154 USING HIGH ORDER COEVOLUTION CORRELATIONS TO IDENTIFY SITES FOR COMPENSATING MUTATIONS TO RESCUE FUNCTION. Kejue Jia , Nikita Chopra, Amy H. Andreotti, Robert L. Jernigan 2609-Pos Board B155 PURIFICATION AND KINETIC CHARACTERIZATION OF PROTEIN TYROSINE PHOSPHATASE 1B (1-393). Kyle M. Jones , Erik Zavala, J. Patrick Loria 2610-Pos Board B156 ALLOSTERIC REGULATION OF GLUTAMATE DEHYDROGENASE. Zoe A. Hoff- pauir , Eleena Sherman, Hong Q. Smith, Thomas J. Smith 2611-Pos Board B157 RCAN1 AND ITS ROLE IN DOWN SYNDROME VIA ITS REGULATION OF CALCINEURIN. Yang Li 2612-Pos Board B158 THERMODYNAMIC PROFILES OF PHOSPHOPROTEINS SUGGEST A GENERAL FUNDAMENTAL ROLE FOR SERINE/THREONINE PHOSPHORYLATION SITES WITH +1 PROLINE (S/T-P) IN EUKARYOTES. Min Hyung Cho , Vincent J. Hilser, James Taylor 2613-Pos Board B159 ENZYME FUNCTION PREDICTION USING DEEP LEARNING. Safyan Aman Memon , Kinaan Aamir Khan, Hammad Naveed 2614-Pos Board B160 EFFECT OF TYR116 IN MYCOBACTERIAL 3-KETOSTEROID-Δ 1 - DEHYDROGENASE ON ITS SUBSTRATE SPECIFICITY. Shikui Song , Xin Li, Tian Chen, Cheryl X. Y. Cheng, Zhengkun Kuang, Yongqi Huang, Zhengding Su 2615-Pos Board B161 SIROHEME SYNTHASE ORIENTS SUBSTRATES FOR DEHYDROGENASE AND CHELATASE ACTIVITES IN A SINGLE ACTIVE SITE. Elizabeth Stroupe , Joseph M. Pennington 2616-Pos Board B162 A COMPUTATIONAL STUDY OF THE ROLE OF THE E3 LIGASE IN THE UBIQ- UITINATION REACTION.  Jay-Anne K. Johnson Board B148

PREDICTING THE P K A SHIFT OF ACIDIC RESIDUES IN THE CALCIUM- BINDING SITES OF SERCA USING ALCHEMICAL FREE-ENERGY CALCULA- TIONS. Rodrigo Aguayo-Ortiz , Laura Dominguez, L. Michel Espinoza- Fonseca 2591-Pos Board B137 VISUALIZING SINGLE MOLECULE DYNAMICS OF SYNTAXIN SIMULTANE- OUS WITH CLUSTERS USING DYE LABELED NANOBODIES. Alan Weisger- ber 2592-Pos Board B138 IMMUNE CELL TRIGGERING BY SPATIAL SEGREGATION STUDIED USING STOCHASTIC RARE EVENT SIMULATION. Robert Taylor , Jun F. Allard, Elizabeth Read 2593-Pos Board B139 USING FLUORESCENCE MICROSCOPY TO CHARACTERIZE THE ROLE OF MECHANOSENSATION IN CELL DIVISION. Allen Lu , Seongjin Park, Bharat Reddy, Jingyi Fei, Eduardo Perozo 2594-Pos Board B140 3D DSTORM IMAGING REVEALS CAMKII-DEPENDENT DISPERSAL OF RY- ANODINE RECEPTOR CLUSTERS IN FAILING RAT CARDIOMYOCYTES. Xin Shen , Terje R. Kolstad, Jonas van den Brink, Michael Frisk, Yufeng Hou, Einar Norden, Andrew G. Edwards, Ivar Sjaastad, Christian Soeller, Wil- liam E. Louch 2595-Pos Board B141 A COMPARISON OF IN VIVO AND IN VITRO BAMA BARREL SEAM DY- NAMICS. Matthew A. Brown 2596-Pos Board B142 INFLUENCE OF PRESENILIN H1-H2 LINKER MUTATIONS ON THE APP PROCESSING BY GAMMA-SECRETASE. Michal M. Olewniczak , Lukasz Nierzwicki, Jacek Czub 2597-Pos Board B143 DYNAMIN PH DOMAIN INTERACTIONS WITH PHOSPHATIDYLINOSITOL LIPIDS IN MEMBRANE.  Joseph A. Marte , Dalia M. Hassan, Frank X. Vázquez 2598-Pos Board B144 Travel Awardee ALUMINIUM INTERACTS DIFFERENTLY WITH LIPID BILAYERS AND MOD- ULATES THE PLASMA MEMBRANE CALCIUM ATPASE (PMCA) ACTIVITY.  Marilina de Sautu , Gustavo Scanavachi, Mariela Soledad Ferreira- Gomes, Juan Pablo F. Rossi, Rosangela Itri, Irene C. Mangialavori 2599-Pos Board B145 ACTIVITY AND SUBSTRATE SPECIFICITY OF FACTOR XIII RESULTING FROM DIFFERENT ACTIVATION PATHWAYS. Rameesa Darul Amne Syed Mohammed , Heli Butala, Muriel Maurer 2600-Pos Board B146 SOLUTION STRUCTURE STUDIES OF ESS1 INTERACTIONS WITH THE RNA- PII CTD SUGGEST A DUAL BINDING MECHANISM THAT DIFFERS FROM THAT OF HUMAN PIN1. Tongyin Zheng , Kevin Namitz, Ashley Canning, Nilda Alicea-Velazquez, Carlos A. Castaneda, Micheal S. Cosgrove, Ste- ven D. Hanes 2601-Pos Board B147 BIOPHYSICAL INVESTIGATION OF THE FUNCTION OF ENZYME 3DL1. Ali A. Khan , Michael Kirsch, Julia R. Koeppe Enzyme Function, Cofactors, and Post-translational Modifications (Boards B145 - B170)

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