Biophysical Society 2020 Annual Meeting

Friday, February 14

12:00 pm EXAMINATION OF HIPSC-CARDIOMYOCYTE MONOLAYERS IN 2.5D – A NEW APPROACH TO UNITE PHYSIOLOGICAL RELEVANCE AND THROUGH- PUT. Matthias Gossmann 12:30 pm LUNCH (PROVIDED) SESSION III Chair: Jeff Roland 1:30 pm THE USE OF HIGH THROUGHPUT MULTI ION CHANNEL PROFILING AND IN SILICO MODELLING IN ASSESSING ARRHYTHMIA RISK - ONE PHARMA’S EXPERIENCE AND PERSPECTIVE. Stephen Jenkinson 2:00 pm HIGH THROUGHPUT SCREENING OF NMDA RECEPTORS. David Dalrymple 2:30 pm STUDY LIGAND GATED ION CHANNELS WITH MICROFLUIDIC BASED HIGH- THROUGHPUT, AUTOMATED ELECTROPHYSIOLOGY PLATFORM. David Wei 3:00 pm COFFEE BREAK SESSION IV Chair: Niels Fertig 3:30 pm SCREENING TOXINS AS ION CHANNEL THERAPEUTICS ON AUTOMATED PATCH CLAMP SYSTEMS: KV1.3 CASE STUDY. Marc Rogers 4:00 pm CHALLENGES FOR THE STRUCTURAL BIOLOGY OF VOLTAGE-GATED ION CHANNELS. Nieng Yan 4:45 pm CLOSING REMARKS Thomas Binzer Registration 3:00 pm - 5:00 pm, Lobby G New Council Orientation 3:30 pm - 4:30 pm, Hilton, Cobalt 501C Joint Council Reception, Dinner, and Meeting 5:00 pm - 9:00 pm, Hilton, Cobalt 500AB Society of General Physiologists Meeting 5:00 pm - 9:00 pm, Room 30D

F R I D A Y

Exhibitor Registration 8:00 am - 5:00 pm, Lobby G Drug Discovery for Ion Channels XX Satellite Meeting 8:00 am - 5:00 pm, Room 29AB Sponsored by Sophion Bioscience; Nanion Technologies; Metrion Biosciences; SB Drug Discovery; and Fluxion Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiologi- cal techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrep- resented target class for drug discovery. The advent of higher throughput automated electrophysiology systems has changed the face of ion chan- nel drug discovery. Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instrumentation and techniques. 8:00 am REGISTRATION, COFFEE, AND LIGHT BREAKFAST 8:45 am WELCOME AND OPENING REMARKS Thais Johansen SESSION I Chair: Mads Korsgaard 9:00 am NONPSYCHOACTIVE ALTERNATIVES TO CANNABIS FOR TREATING PAIN: DISCOVERING NOVEL GLYCINE RECEPTOR MODULATORS BY AUTOMATED ELECTROPHYSIOLOGY. Yan Xu 9:30 am SODIUM CHANNEL BLOCKERS INHIBITING HUMAN SENSORY NEURONS IN DIVERSE PATHOLOGICAL STATES. Andre Ghetti 10:00 am UPDATE ON IHMRI’S HIGH THROUGHPUT E-PHYS CORE. Rocio Finol-Urdaneta 10:30 am COFFEE BREAK SESSION II Chair: Marc Rogers 11:00 am IDENTIFICATION OF NOVEL KV7.2/KV7.3 PAMS USING ADVANCED HIGH- THROUGHPUT SCREENING TOOLS. Jean-Francois Roland 11:30 am ELECTROPHYSIOLOGICAL EVALUATION OF NOVEL SMALL-MOLECULE NAV1.7-SELECTIVE STATE-INDEPENDENT PORE BLOCKERS. Anton Delwig

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