Biophysical Society 2020 Annual Meeting

Platform Cardiac Muscle Mechanics and Structure 8:15 am - 10:15 am, Room 23ABC Co-Chairs Mathias Gautel, King’s College London, United Kingdom Rhye-Samuel Kanassatega, University of Arizona 27-Plat 8:15 am HIGH-THROUGHPUT PRODUCTION AND BIOPHYSICAL CHARACTERIZA- TION OF WILD TYPE AND VARIANT TITIN DOMAINS. Martin Rees, Alex- ander Alexandrovich, Roksana Nikoopour, Sarah Grover, Anna Laddach, Franca Fraternali, Heinz Jungbluth, Mathias Gautel 28-Plat 8:30 am THE SPECIFIC CLEAVAGE OF TITIN SPRINGS TO QUANTIFY THE CONTRIBU- TION OF TITIN TO MYOCARDIAL PASSIVE STIFFNESS.  Johanna K. Freundt, Christine Loescher, Andreas Unger, Ivan Liashkovich, Yong Li, Julio M. Fernandez, Wolfgang A. Linke 29-Plat 8:45 am BAG3 LOCALIZES TO THE MATURE SARCOMERE AND MAINTAINS MYO- FILAMENT FUNCTION.  Thomas Martin 30-Plat 9:00 am IMPACT OF MAVACAMTEN ON FORCE GENERATION IN SINGLE MYOFI- BRILS FROM RABBIT PSOAS AND HUMAN CARDIAC MUSCLE.  Beatrice Scellini, Nicoletta Piroddi, Marica Dente, Cecilia Ferrantini, Raffaele Cop- pini, Corrado Poggesi , Chiara Tesi 31-Plat 9:15 am FRET MEASUREMENTS OF THE POWER STROKE IN HUMAN CARDIAC MYOSIN. Wanjian Tang , Jinghua Ge, Rohini Dessety, Christopher M. Yengo 32-Plat 9:30 am STRUCTURE OF THE ACTIN-TROPOMYOSIN-TNT COMPLEX.  Matthew Doran , Anita Ghosh, William Lehman, Esther Bullitt 33-Plat 9:45 am MECHANICAL SIGNATURES DRIVING HCM AND DCM REVEALED IN HU- MAN ENGINEERED HEART TISSUES EXPRESSING CARDIOMYOPATHY-AS- SOCIATED VARIANTS IN TPM1.  Lorenzo R. Sewanan , Stuart G. Campbell 34-Plat 10:00 am Travel Awardee A FRET-BASED BIOSENSOR FOR DETECTING PHOSPHORYLATION-DEPEN- DENT STRUCTURAL DYNAMICS IN HUMAN MYOSIN BINDING PROTEIN-C.  Rhye-Samuel Kanassatega , Thomas A. Bunch, Christopher Wang, Victoria C. Lepak, Brett A. Colson Platform Member Organized Session: Multiscale Genome Organization 8:15 am - 10:15 am, Room 24ABC Co-Chairs A BALANCE BETWEEN ELASTIC AND RIGIDIFIED CENP-A NUCLEOSOMES GOVERN CENTROMERIC CHROMATIN FIDELITY.  Daniël P. Melters , Mary Pitman, Tatini Rakshit, Emilios K. Dimitriadis, Minh Bui, Garegin A. Papoian, Yamini Dalal 36-Plat 8:30 am NUCLEOSOME CLUTCHES IN CHROMATIN ARE TIGHTLY REGULATED BY NUCLEOSOME POSITIONS AND LINKER HISTONE DENSITY.  Stephanie Portillo , Lucille H. Tsao, Tamar Schlick Yamini Dalal, National Cancer Institute Tamar Schlick, New York University, HHMI 35-Plat 8:15 am

37-Plat 8:45 am UNRAVELING THE NUCLEOSOME THROUGH MICROSCOPIC SIMULA- TIONS.  David N. Winogradoff , Aleksei Aksimentiev 38-Plat 9:00 am COMPUTATIONAL MODELING OF NUCLEOSOMAL MECHANICS AND EPIGENETIC MODIFICATIONS. Mary Pitman , Yamini Dalal, Garegin A. Papoian, Daniël P. Melters, Tatini Rakshit, Emilios K. Dimitriadis, Minh Bui 39-Plat 9:15 am A LIBRARY FOR COMPARATIVE ALL ATOM STUDIES OF NUCLEOSOMES.  Ran Sun , Thomas C. Bishop 40-Plat 9:30 am ELUCIDATING ARCHAEAL CHROMATIN “SLINKY” DYNAMICS THROUGH SIMULATION AND EXPERIMENT.  Samuel Bowerman , Daren Kraft, Jeff Wereszczynski, Karolin Luger 41-Plat 9:45 am ANALYZING NUCLEOSOME PLASTICITY VIA ATOMISTIC MD SIMULATIONS. Anastasiia Kniazeva, Grigorii Armeev, Iunona Pospelova, Alexey K. Shaytan 42-Plat 10:00 am CONNECTING NUCLEOSOMAL DNA FOLDING TO CHROMATIN ARCHITEC- TURE AND PROPERTIES.  Stefjord Todolli , Wilma K. Olson Platform Ion Channel Regulatory Mechanisms 8:15 am - 10:15 am, Room 25ABC Co-Chairs Rose Dixon, University of California, Davis Izhar Karbat, Weizmann Institute of Science, Israel 43-Plat 8:15 am Travel Awardee BETA-ADRENERGIC STIMULATION OF CAV1.2 CHANNELS IS TRANSDUCED VIA THE IS6-AID LINKER.  Arianne Papa , Jared Kushner, Jessica Hen- nessey, Alexander N. Katchman, Sergey I. Zakharov, Bi-xing Chen, Lin Yang, Ree Lu, Stephen Leong, Johanna Diaz, Henry M. Colecraft, Geoffrey S. Pitt, Manu Ben-Johny, Steven O. Marx 44-Plat 8:30 am Β-ADRENERGIC RECEPTOR-MEDIATED SIGNALING PROMOTES EN- HANCED SARCOLEMMAL INSERTION OFCA V 1.2 FROM RAB4-POSITIVE ENDOSOMES.  Silvia Garcia del Villar , Eamonn J. Dickson, Rose E. Dixon 45-Plat 8:45 am HETROMERIZATION OF KIR CHANNELS: PRINCIPLES OF ASSEMBLY AND PHYSIOLOGICAL SIGNIFICANCE.  Alice Mett , Shachar Fine, Astrid Kollewe, Izhar Karbat, Bernd Fakler, Eitan Reuveny 46-Plat 9:00 am ISOFORM-SPECIFIC REGULATION OF HCN4 CHANNELS BY A FAMILY OF NOVEL INTERACTING PROTEINS.  Colin H. Peters , John Bankston, Cathy 9:15 am NATIVE-STATE PROLYL ISOMERIZATION IS INVOLVED IN THE ACTIVATION OF A CNG CHANNEL.  Philipp A. Schmidpeter , Crina M. Nimigean 48-Plat 9:30 am STEPWISE DISSOCIATION OF AN INNER GATE CONTROLS PORE OPENING IN THE CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A.  Andy Lam , Raimund Dutzler Proenza 47-Plat

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