Biophysical Society 2020 Annual Meeting

Exhibitor Presentation Dynamic Biosensors GmbH 2:30 pm - 4:00 pm, Room 33C

Early Careers Committee Meeting 3:30 pm - 5:00 pm, Room 30D Exhibitor Presentation Bruker Corporation 3:30 pm - 5:00 pm, Room 33A Multiplexed Imaging and Superresolution Microscopy Using the Vutara 352 Microscope with Integrated Fluidics System The Vutara 352 super resolution microscope has been designed for single molecule localization microscopy in multiple types of biological samples. However, most current methods for super resolution micros- copy are limited to three- to four-targets due to the limited number of dyes compatible with quality super resolution techniques. This talk pres- ents a method for multiplexing single molecule localization microscopy imaging within a biological sample through the use of an integrated automated microfluidics system. Probe multiplexing allows for the imag- ing of greater than four different targets within a cell. Using the Vutara 352 and integrated fluidics unit we will show the three-dimensional oli- goSTORM imaging of a multiplexed oligoPAINT labeled chromosome in individual human fibroblast cells along with 3D multi probe DNA-PAINT based single molecule localization data for antibody labeled targets in cell culture and tissue slices. The Vutara 352 with integrated fluidics and SRX software provides a powerful suite of tools for simultaneous imaging, localization, visualization and statistical analysis of multiplexed single molecule super resolution data. Speaker Robert Hobson, Applications Scientist, Bruker Corporation Career Development Center Workshop Nailing the Job Talk, or Erudition Ain’t Enough 4:00 pm - 5:00 pm, Room 26A Congratulations! You’ve made it to the finals and are suddenly facing the most important presentation of your life. Answers to your questions about how to structure your presentation, how much detail to include, what they are really looking for, etc. Biophysical Journal Associate Editors Meeting 4:00 pm - 6:00 pm, Room 30E Symposium Anion Channels 4:00 pm - 6:00 pm, Ballroom 20A Chair Criss Hartzell, Emory University 115-Symp 4:00 pm MECHANISMS OF CLC CL - /H + TRANSPORTERS. Merritt Maduke 116-Symp 4:30 pm INTRACELLULAR CLC TRANSPORTERS - FROM KIDNEY STONES TO INTEL- LECTUAL DISABILITY. Michael Pusch , Alessandra Picollo, Sara Bertelli, Giovanni Zifarelli, Elizabeth E. Palmer, Vera Kalscheuer 117-Symp5:00 pm GATING DYNAMICS, REGULATION AND PHARMACOLOGY OF THE CFTR ANION CHANNEL.  László Csanády , Csaba Mihályi, Beáta Töröcsik 118-Symp 5:30 pm AMAZING ANOCTAMINS (TMEM16) ALL AROUND.  Criss Hartzell , Kuai Yu, Steven Foltz, Hyojung Choo, Jarred M. Whitlock

S U N D A Y

switchSENSE® Biophysical Analysis with Electro-Switchable Biosurfaces The presentation will highlight the broad range of applications of the switchSENSE® technology that is supported by the recently launched heliX® biosensor: • Size and Conformational Change – Screening and ranking of small molecule induced conformational changes by de novo real-time conformation referencing • Bispecific Antibodies – Bifunctional sensor functionalization, ad- vanced ligand density control and two-color fluorescence detection for the in-depth analysis of bispecific binders • Resolving the fastest kinetics with confidence using advanced micro- fluidics and 10 ms data collection • DNA/RNA Binding Proteins – Flexible exchange of DNA/RNA targets for binding and enzymatic activity studies in real-time • From Small Molecules to Cells – Chip functionalization solutions for the biophysical characterization of very small or very large structures Speakers Ulrich Rant, CEO, Dynamic Biosensors GmbH Aishwarya Mahadevan, Application Specialist, Dynamic Biosensors Inc Science and Research in the Global Political Landscape The US and China 2:30 pm - 4:00 pm, Room 29C Science has always thrived on collaborations, with many significant ad- vances resulting from the coordinated efforts of multiple research teams, frequently based in different countries. China’s recent increased invest- ment in science and technology has been accompanied by increasing numbers of international scientific collaborations involving scientists at Chinese institutions, with collaborations involving US scientists compris- ing the largest share. The high level of US‐China scientific collaboration has coincided with trade disputes and concerns about intellectual property theft. The United States Congress has begun to actively pursue legislation to protect the products of US research efforts from foreign governments. At the same time, the US agencies overseeing federal research grants have initiated investigations into grantees with undisclosed collaborative agreements with foreign governments amidst allegations of ‘double dipping.’ As US‐China tensions continue to rise, what are the long‐term repercus- sions for scientific research – an endeavor that has always thrived on collaborative efforts and global perspectives? What is the impact of uni- versity and federal agency investigations on the participation of Chinese nationals in the US scientific enterprise? Moderator Dorothy Beckett, University of Maryland Panelists Michael Lauer, NIH Frank H. Wu, University of California, Hastings College of the Law

Tai-Ming Cheung, University of California, San Diego Sandra Brown, University of California, San Diego

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