Biophysical Society 2020 Annual Meeting

Platform Excitation-Contraction Coupling 4:00 pm - 6:00 pm, Room 31ABC

PI to PI A Wine & Cheese Mixer 4:00 pm - 6:00 pm, Room 28AB

F R I D A Y

S U N D A Y

Co-Chairs Donald Bers, University of California, Davis Montserrat Samso, Virginia Commonwealth University School of 4:00 pm ELUCIDATION OF MECHANISM OF CA 2+ INDUCED CA 2+ RELEASE OF RYR2 REVEALED BY CRYO-EM.  Takuya Kobayashi, Akihisa Tsutsumi, Nagomi Kurebayashi, Kei Saito, Takashi Sakurai, Masahide Kikkawa, Takashi Murayama, Haruo Ogawa 163-Plat 4:15 pm STRUCTURAL INSIGHT ON THE REGULATION OF RYR1 BY CALCIUM AND MAGNESIUM.  Ashok R. Nayak, Alex H. Will, Joshua Lobo, Pablo Castro- Hartmann, Montserrat Samso 164-Plat 4:30 pm ALTERNATIVE SPLICING OF CA V 1.2 IN ARVC PATIENTS.  Theresa Bourjau, Valentina Di Biase, Marta Campiglio, Maria Giglberger, Barbara Schober, Teresa Stauber, Gabriela Pietrzyk, Andrea Baessler, Marcus Fischer, Stefan Wagner, Lars S. Maier, Karin P. Hammer 165-Plat 4:45 pm TRPV4 CONTRIBUTES TO PRO-ARRHYTHMIC CALCIUM SIGNALING IN CARDIOMYOCYTES OF AGED MICE.  Deborah Peana , Timothy L. 5:00 pm CARDIAC CAMKIIΔ MEMORY: HOW POST-TRANSLATIONAL-MODIFICA- TIONS ALTER CALMODULIN AFFINITY. Mitchell Simon , Christopher Y. Ko, Sonya Baidar, Razvan L. Cornea, Julie Bossuyt, Donald M. Bers 167-Plat 5:15 pm EFFECT OF BAPTA AND DYSFERLIN’S C2A DOMAIN ON RECOVERY OF CA 2+ TRANSIENTS AFTER OSMOTIC SHOCK IN DYSFERLIN-NULL MYOFI- BERS. Valeriy I. Lukyanenko , Joaquin M. Muriel, Robert J. Bloch 168-Plat 5:30 pm HUMAN BIN1 ISOFORMS MAINTAIN, REGENERATE AND ELICIT FUNC- TIONAL EC-COUPLING AND COUPLONS IN ADULT RAT AND HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES.  Peter Lipp , Jia Guo, Qinghai Tian, Monika Barth, Wenying XIan, Sandra Ruppenthal, Hans-Joachim Schaefers, Zhifen Chen, Alessandra Moretti, Karl-Ludwig Laugwitz 169-Plat 5:45 pm THE E258K- MYPBC3 MODELLED IN HCM PATIENT-DERIVED CARDIO- MYOCYTES TO IDENTIFY THE PRIMARY IMPACT OF THE MUTATION VERSUS THE SECONDARY CHANGES DUE TO CARDIAC REMODELING.  J. M. Pioner , Sonette Steczina, Giulia Vitale, Saffie Mohran, Chiara Palandri, Lorenzo Santini, Silvia Querceto, Marianna Langione, Elisabetta Cerbai, Chiara Tesi, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi, Michael Regnier Medicine 162-Plat Domeier 166-Plat

You finally have a job working in biophysics, in industry or academia, with some funding and a lab, but you’ve realized that the career chal- lenges continue. Come relax and network with your contemporaries and senior biophysicists over a beer or glass of wine. This event is a great chance to compare notes with colleagues and discuss one-on-one your unique solutions to issues that arise in the time between getting your job and getting your next promotion, including management of lab staff, getting your work published, and renewing your funding. Refresh- ments will be provided, with cash bar. Exhibitor Presentation ELEMENTS SRL 5:30 pm - 7:00 pm, Room 33A Low-Noise, Handheld Amplifiers for Electrophysiology and Nanopore Applications Ultra-portable and cost-effective amplifier technology is now a reality accessible to any electrophysiology research lab, thanks to Elements miniaturized products, based on our custom CMOS microchips. In this presentation, we will be featuring our latest products through the hands-on experience of current customers from the US, Europe, and Japan. You will hear first-hand accounts about their research and the results they got using: • The world’s smallest integrated patch clamp amplifier, ePatch • A handheld nanopore kit for nanoparticle detection using dispos- able glass nanopore chips, eNPR Attend this presentation to learn about: • The advantages of using a versatile and compact nano-current amplifier technology • Portable nanopore solution for protein detection using disposable nanopore chips • How the world’s smallest and cheapest patch clamp amplifier is radically changing patch-clamp measurements • Different user experience ranging from patch-clamp on live cells, to exosome detection using solid state nanopores, as well as lipid bilayer experiments Complimentary Italian hors d’oeuvres and drinks will be served. Seating Federico Thei, Chief Executive Officer, ELEMENTS SRL Alessandro Porro, Application Scientist, ELEMENTS SRL Guilherme Henrique Bomfim, Researcher, New York University Nelly Mnatsakanyan, Assistant Professor, Yale University David Niedzwiecki, Scientist, Goeppert LLC Mark Platt, Senior Lecturer, University of Loughborough Masato Nishio, Tokyo University is limited. Speakers

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