Biophysical Society 2020 Annual Meeting

197-Pos Board B28 ROLE OF PROLYL ISOMERIZATION IN METAMORPHOSIS OF THE CLOCK PROTEIN, KAIB. Madhurima Das 198-Pos Board B29 THE STRUCTURE OF LRRK2 AND THE CONFORMATIONAL CHANGES THAT ARE ASSOCIATED WITH LRRK2 ACTIVATION AND PARKINSON’S DISEASE PATHOGENESIS.  Jui-Hung Weng 199-Pos Board B30 SINGLE PARTICLE CRYO-EM STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS INTERACTING WITH TAU. Alimohammad Hojjatian , Anvesh K.R. Dasari, Dianne Taylor, Nadia Daneshparvar, Fatemeh A. Abbasi Yeganeh, Kwang Hun Lim, Kenneth A. Taylor 200-Pos Board B31 STRUCTURES AND MECHANISM OF HUMAN TRPM2 DESENSITIZATION AND INHIBITION. Longfei Wang , Tianmin Fu, Shiyu Xia 201-Pos Board B32 ELUCIDATING THE STRUCTURAL BASIS OF PROTEIN DOMAIN COUPLING IN SPECTRIN REPEAT DOMAINS. Althea Amaris , Madison Nohner, Michael Fealey, Katie M. Dunleavy, Gail E. Fanucci, Jessica Sieber, Anne Hinderliter 202-Pos Board B33 STRUCTURAL CHARACTERIZATION AND SURFACE ADSORPTION OF S. EPIDERMIDIS AUTOLYSIN E - AMIDASE, A PROTEIN IMPLICATED IN BIOFILM FORMATION. Rahul Yadav , Nicholas C. Fitzkee 203-Pos Board B34 NEW STRUCTURAL INSIGHTS INTO THE FUNCTION OF THE ACTIVE FULL LENGTH HUMAN TASPASE1: A NOVEL ANTICANCER THERAPEUTIC TARGET. Rebecca J. Jernigan , Nirupa Nagaratnam, Darren Thifault, Silvia Delker, Michele Zacks, Thomas Edwards, Lidia Sambucetti, Liang Tong, Raimund Fromme, Joel Schneider, James Hsieh, Barbra Mroczkowski, Andrew Flint, Petra Fromme, Jose M. Garcia 204-Pos Board B35 NOVEL INSIGHTS INTO THE STRUCTURAL PERTURBATION INDUCED BY THE ONCOGENIC MUTATIONS, Q61L AND Q61H, IN RAS STATE 1. Shigeyuki Matsumoto , Haruka Taniguchi-Tamura, Mitsugu Araki, Takashi Kawamura, Ryo Miyamoto, Chiemi Tsuda, Yasushi Okuno, Fumi Shima, Takashi Kumasaka, Tohru Kataoka Protein Structure, Prediction, and Design I (Boards B36 - B53) 205-Pos Board B36 MOLECULAR DESIGN FOR RESEARCH AND THERAPEUTICS.  Nikolay V. Dokholyan 206-Pos Board B37 STATISTICAL PROPERTIES OF FOLDED PROTEINS’ SEQUENCES: PREDICT- ING FOLDABILITY AND EFFECT OF MUTATIONS. Mihaly Mezei 207-Pos Board B38 DESIGN OF GLOBIN-LIKE COMPLICATED FOLDS. Koya Sakuma , Kano Suzuki, Takahiro Kosugi, Takeshi Murata, Toshihiko Sugiki, Naohiro Kobayashi, Naoya Kobayashi, Rie Koga, Nobuyasu Koga 208-Pos Board B39 EXPLORATION OF NOVEL ALPHA-BETA PROTEIN FOLDS BY DE NOVO DESIGN. Shintaro Minami , Rie Koga, George Chikenji, Toshihiko Sugiki, Naohiro Kobayashi, Nobuyasu Koga 209-Pos Board B40 THE MATHEMATICS OF SECONDARY STRUCTURES IN PROTEINS.  Magdalena D. Toda , Bhagya Athukorallage

210-Pos Travel Awardee PROTEIN SECONDARY STRUCTURE DETECTION IN INTERMEDIATE- RESOLUTION CRYO-EMMAPS USING DEEP LEARNING. Sai Raghavendra Maddhuri Venkata Subramaniya , Genki Terashi, Daisuke Kihara 211-Pos Board B42 PROTEIN LOOP MODELING USING DEEP NEURAL NETWORKS ENHANCED BY REINFORCEMENT LEARNING. Feng Pan , Yuan Zhang, Chun-Chao Lo, Xiuwen Liu, Jinfeng Zhang 212-Pos Board B43 PRODCONN - PROTEIN DESIGN USING A CONVOLUTIONAL NEURAL NET- WORK. Yuan Zhang , Yang Chen, Chenran Wang, Chun-Chao Lo, Xiuwen Liu, Wu Wei, Jinfeng Zhang 213-Pos Board B44 EDES: A PROTOCOL TO GENERATE HOLO-LIKE AND DRUGGABLE PROTEIN CONFORMATIONS STARTING FROM THE APO STRUCTURE. Andrea Basciu, Giuliano Malloci, Panos Koukos, Fabio Pietrucci, Alexandre M.J.J. Bonvin, Attilio V. Vargiu 214-Pos Board B45 USING SEQUENCE AND STRUCTURE INFORMATION TO ANNOTATE GENE AND PROTEIN FUNCTION. Benjamin R. Litterer , Kejue Jia, Sayane Shome, Robert L. Jernigan 215-Pos Board B46 IDENTIFICATION OF SWITCH-LIKE FEATURES IN PROTEINS USING SEQUENCE-BASED DESCRIPTORS MODELLED FROM REGIONS IDENTIFIED IN X-RAY CRYSTAL STRUCTURES.  Jonathan Oribello , Benjy Strauss, Charles Qui, Angelina Huynh, Edgardo Millan, Khai Cao, Ningkun Wang, Brooke Lustig 216-Pos Board B47 Travel Awardee COMPARATIVE PHOTOPHYSICAL STUDIES OF OF MCERULEAN3 AND MTURQUOISE2.1 AS FRET DONORS.  Julie A. Beenken , Emmanuel Tetteh- Jada, Cody P. Aplin, Taryn M. Kay, Arnold J. Boersma, Ahmed A. Heikal, Erin D. Sheets 217-Pos Board B48 LONG-RANGE REGULATION OF CYTOCHROME C BINDING TO BC1 COM- PLEX. Natalie L. Simmons , Spencer B. Grewe, Oleksandr Kokhan 218-Pos Board B49 DEVELOPING A CARBON-CONSERVING PHOTORESPIRATION BYPASS PATHWAY BYPASS PATHWAY THROUGH ANCESTRAL GENOME MINING AND ENGINEERING. Brian L. Ross , Devin Trudeau, Arren Bar-Even, Dan Tawfik 219-Pos Board B50 COMBINING IN SILICO PHYLOGENETIC AND THREADING APPROACHES TO ASSIST THE IN VITRO PROTEIN ENGINEERING OF BVMO ENZYMES. Joseph S. Rebehmed , Alexandre G. de Brevern 220-Pos Board B51 COMPUTATIONAL DESIGN OF A STABLE DIII PENTAMER OF DENGUE VIRUS ENVELOPE PROTEIN AS AN IMMUNOGEN WITH ROSETTA.  Colleen Maillie , Thanh Thanh Phanh, Brian Kuhlman 221-Pos Board B52 MOLECULAR DESIGN OF SOLUBLE ZEIN PROTEIN SEQUENCES.  Mohammad Madani , Anna Tarakanova 222-Pos Board B53 CHARACTERIZATION OF MECHANICS AND TUNABILITY OF RESILIN PROTEIN BY MOLECULAR DYNAMICS SIMULATION. Mohammad Madani , Anna Tarakanova Board B41

F R I D A Y

S U N D A Y

29