Biophysical Society 2020 Annual Meeting

Exhibitor Presentation HORIBA Scientific 2:30 pm - 4:00 pm, Room 33C A NewModular Research Fluorometer Pushes Detection, Stray-Light, and Wavelength Limits of Fluorescence Spectroscopy HORIBA Instruments Inc is proud to introduce the new FluorologQM modular research spectrofluorometer. This is the fourth generation of the world famous, all reflective, Fluorolog modular research spectrofluorom- eter and it pushes the sensitivity, performance and flexibility of fluores- cence spectroscopy to new heights. Featuring the world’s highest guar- anteed sensitivity specification, the longest focal length monochromators in the industry, and a wavelength coverage range from 180 to 5,500 nm, the FluorologQM pushes the detection, stray light, and wavelength limits of fluorescence to new levels. With new software, a new design and complete automation, this advanced research fluorometer, is also equally well suited for the simplest of tasks. The biophysical applications of the FluorologQMwill be presented. Speaker Cary Davies, Global Product Manager-Fluorescence Division, HORIBA Scientific Exhibitor Presentation Applied Photophysics 3:30 pm - 5:00 pm, Room 33A Discover When Change is Significant: Latest Developments in Circular Dichroism and Stopped-Flow Kinetics Applied Photophysics has remained at the forefront of the technologies of circular dichroism and stopped-flow kinetics since its creation in 1971 by the Royal Institution of Great Britain under the leadership of Nobel Prize-winning Lord Port. In the first part of the presentation, the latest developments regarding the Chirascan CD spectrometers will be introduced. Case studies will be discussed to illustrate that CD spectroscopy with Chirascan is far more powerful than the traditional use of revealing the protein secondary structures such as α-helix and β-sheet. With Chirascan CD spectrometers, information regarding secondary structures, as well as tertiary structures, thermal and chemical stability can be clearly demonstrated. Moreover, the introduction of automatic CD spectrometers provides unparalleled sensitivity, reproducibility and productivity. It provides a novel approach for objective, quantifiable higher order structure (HOS) comparisons. The introduction of the Circularly Polarized Luminescence (CPL) accessory makes the Chirascan more economical and versatile. In the second part of the presentation, the latest developments in the SX Stopped-Flow systems will be discussed. Stopped-Flow systems from Ap- plied Photophysics are known for its high performance, ease-of-use and durability and we have made them better. We introduce LED light sources and various accessories, such as dual fluorescence detection, fluores- cence polarization/anisotropy, and photodiode array detector. Applica- tions in enzymology and protein structures will be discussed. Speakers Marc Neglia, Sales Director, Applied Photophysics Americas Frank Yuan, Applications Scientist, Applied Photophysics Darek Silwa, Sales Manager, Applied Photophysics

Career Development Center Workshop Marketing Your Value: Crafting Your Elevator Pitch/30 Second Value Statement/Brand Statement 4:00 pm - 5:00 pm, Room 26A I have a brand and you have a brand. A brand is simply a promise of value and every successful professional and company is successful in part because they know how to articulate their brand. The ability to com- municate your promise of value is vitally important for not only crafting your own career path, but also for finding out about hidden opportuni- ties and jobs. In this workshop, we learn the fundamentals of branding as it relates to career development and planning strategy. We will work together to develop your own 30-second brand statement which you can use in networking, and informational and job interviews. We will discuss the connection between brand, attitude and reputation, and why every interaction with someone affects how people perceive your brand. You will leave this presentation with the ability to elucidate your own brand to whomever you meet, giving you a critical competitive edge in your career and the job market. Symposium Kinetic Stability: Controlling Longevity at the Molecular Level 4:00 pm - 6:00 pm, Ballroom 20A Chair Jonathan King, MIT 877-symp4:00 pm DESIGNING PROTEIN STABILITY AND STRAIN FOR FOLDING AND FUNC- TION.  Elizabeth M. Meiering 878-symp4:30 pm COMPETING INTERACTIONS BETWEEN VIRAL RHIM AMYLOID-FORMING PROTEINS AND HOST FUNCTIONAL AMYLOID STRUCTURES MODULATE THE CELLULAR RESPONSE TO INFECTION. Margaret Sunde , Chi L.L. Pham, Nirukshan Shanmugam, Max O.D.G. Baker, Megan Steain, Ailis O’ Carroll, James W. Brown, Emma Sierecki, Yann Gambin 879-symp5:00 pm PROTEOMICS ANALYSES OF KINETIC STABILITY: FROMMOLECULAR TO ORGANISM LONGEVITY. Wilfredo Colon , Evelyn G. Rugaber, Ke Xia 880-symp5:30 pm BURIED TRYPTOPHANS CONTRIBUTING TO THE HIGH KINETIC STABILITY OF THE LONG-LIVED GAMMA CRYSTALLINS AND THEIR OXIDATIVE DAM- AGE OPENING THE PATHWAY TO THE AGGREGATED STATE ASSOCIATED WITH CATARACTS.  Jonathan King , Ishara Mills Henry, Melissa Kosinski- Collins, Shannon Thol, Eugene Serebryany Symposium Translational Control 4:00 pm - 6:00 pm, Ballroom 20D Chair Christine Dunham, Emory University 881-symp 4:00 pm NASCENT POLYPEPTIDE CHAIN-MEDIATED TRANSLATION ELONGATION ARREST IN BACTERIA.  Shinobu Chiba 882-symp 4:30 pm PRECISELY QUANTIFYING THE ENERGETICS OF THE RIBOSOME. Mariana Levi, Jeffrey Noel, Huan Yang, Trung Kien Nguyen, Asem H. Hassan, Kelsey N. Walak, Jonathan Perrier, Liah Dukaye, Ransom Horne, Paul C. Whitford

M O N D A Y

Membership Committee Meeting 3:30 pm - 5:30 pm, Room 30D

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