Biophysical Society 59th Annual Meeting Program Guide

2146-P os B oard B283 DISCONTINUITY BETWEEN THE VOLTAGE-SENSOR AND THE PORE DOMAIN DOES NOT ABOLISH VOLTAGE-GATING OF KV10.1 POTASSIUM CHANNEL. Adam P. Tomczak , Eva Lörinczi, Juan Camilo Gomez-Posada, Walter Stühmer, Luis A. Pardo 2147-P os B oard B284 TWO KCNQ1 MUTATIONS ASSOCIATED WITH FAMILIAL ATRIAL FIBRILLATION, S140G AND V141M, DEMONSTRATE DISTINCT VOLTAGE SENSOR PHENOTYPES. Gary Peng , Kevin J. Sampson, Rene Barro-Soria, H. Peter Larsson, Robert S. Kass 2148-P os B oard B285 MOLECULAR DETERMINANTS OF VOLTAGE SENSOR DOMAIN ACTIVATION. Lucie Delemotte , Vincenzo Carnevale, Michael L Klein, Marina A. Kasimova, Mounir Tarek 2149-P os B oard B286 ROLE OF THE VOLTAGE SENSING DOMAIN S1-S4 IN TRPV1 CHANNELS. Juan Zhao , Rikard Blunck 2150-P os B oard B287 SENSING THE ELECTROCHEMICAL K + GRADIENT: THE VOLTAGE GATING MECHANISM IN K2P POTASSIUM CHANNELS. Marcus Schewe , Ehsan Nematian-Ardestani, Thomas Linke, Klaus Benndorf, Stephen J. Tucker, Markus Rapedius, Thomas B oard B288 CAN CLC-2 CHLORIDE CHANNEL BE ACTIVATED BY HYPERPOLARIZATION ALONE IN CELLS DIALYZED WITH NON-PERMEANT ANIONS? José J. De Jesús-Pérez, Alejandra Castro- Chong, Ru-Chi Shieh, Carmen Y. Hernández-Carballo, Jose A. De Santiago-Castillo, Jorge Arreola 2152-P os B oard B289 MOLECULAR BASIS OF VOLTAGE-DEPENDENT GATING IN CLC TRANSPORTERS. Jan-Philipp Machtens , Matthias Grieschat, Christoph Fahlke, Alexi K. Alekov 2153-P os B oard B290 MULTIPHASIC PROFILES: DISCONTINUOUS TRANSITIONS IN CONDUCTANCE-VOLTAGE DATA FOR ION CHANNELS. B oard B291 A HIGHLY COOPERATIVE AND STEEPLY VOLTAGE GATED CHANNEL TRIPLET. Shang H. Lin , Benjamin Wu, Marco Colombini Ligand-gated Channels II (Boards B292-B318) 2155-P os B oard B292 NON-EQUIVALENT LIGAND SELECTIVITY OF AGONIST SITES IN ( α 4 β 2)2 α 4 NICOTINIC ACETYLCHOLINE RECEPTORS: A KEY DETERMINANT OF AGONIST EFFICACY. Simone Mazzaferro , Federica Gasparri, karina New, Constanza Alcaino, Isabel Bermudez 2156-P os B oard B293 DESFORMYLFLUSTRABROMINE POTENTIATES HIGH- SENSITIVITY α 4 β 2 RECEPTORS BY INCREASING CHANNEL OPENING RATE. Arianna Demmerly , Brian W. Edmonds 2157-P os B oard B294 IS THE ACHR A CUCKOO-CLOCK? LOCAL AND REMOTE INTERACTIONS OF THE α M2-3 LINKER IN GATING. Shaweta Gupta , Prasad Purohit, Anthony Auerbach Baukrowitz 2151-P os Per Nissen 2154-P os

2158-P os B oard B295 MOLECULAR SIMULATIONS OF MUSCLE ACHR AGONIST BINDING SITES. Srirupa Chakraborty , Tapan K. Nayak, Iva Bruhova, Wenjun Zheng, Anthony L. Auerbach 2159-P os B oard B296 DIFFERENCES IN AGONIST ENERGY AT THE NEUROTRANSMITTER BINDING SITES IN THE NEUROMUSCULAR ACETYLCHOLINE RECEPTORS. Tapan K. Nayak , Anthony Auerbach 2160-P os B oard B297 INTERACTION OF 7-METHOXYTACRINE-ADAMANTYLAMINE CHOLINESTERASE INHIBITORS WITH NICOTINIC AND MUSCARINIC ACETYLCHOLINE RECEPTORS. Ze-Jun Wang, Vendula Sepsova, Katarina Spilovska, Tasnim S. Mohamed, Ayman K. Hamouda 2161-P os B oard B298 STEPCHILD NICOTINE: EFFECT OF THE NAME-GIVING AGONIST ON MUSCLE-TYPE NICOTINIC ACETYLCHOLINE RECEPTOR. Abhilasha Ladha , Klaus Benndorf, Jana Kusch 2162-P os B oard B299 THE ROLE OF THE M3 HELIX IN ACHR GATING AND PAM ACTION. Aashutosh Vihani , Prasad Purohit, Anthony Auerbach 2163-P os B oard B300 MODAL GATING OF MUSCLE ACHRS HAVING LOOP C MUTATIONS. Ridhima Vij 2164-P os B oard B301 DISSECTING THE INHIBITORY AND POTENTIATION EFFECTS OF DESFORMYLFLUSTRABROMINE ON A MUSCLE-TYPE NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR). Tasnim S. Mohamed , Ze-Jun Wang, Tiffany R. Trevino, Ayman K. Hamouda 2165-P os B oard B302 international travel awardee EXPLORING ALPHA7 POSITIVE ALLOSTERIC MODULATORS FROM A SINGLE-CHANNEL PERSPECTIVE. Natalia D. Andersen , Jeremias Corradi, Fernanda Tolosa, Nehuen Gasparini, Hugo R. Arias, Cecilia B. Bouzat 2166-P os B oard B303 GATING RITUAL: SIMULATIONS OF GATING IN GLUTAMATE- GATED CHLORIDE CHANNEL. Ozge Yoluk , Stephanie Heusser, Magnus Andersson, Laura Orellana, Erik Lindahl 2167-P os B oard B304 AROMATIC RESIDUES IN THE TRANSMEMBRANE HELICES PLAY AN ESSENTIAL ROLE IN THE HOMOPENTAMERIC ASSEMBLY OF THE GLUCL α . Anke Dopychai , Clairentine F. Pokam, Gunther Schmalzing 2168-P os B oard B305 OPENING AND SELECTIVITY OF THE GLIC LIGAND- GATED ION CHANNEL CAN BE TUNED BY MUTATION OF HYDROPHOBIC RESIDUES IN THE PORE. Özge Yoluk, Stephanie Heusser, Iman Pouya, Rebecca Howard, Göran Klement, Erik Lindahl 2169-P os B oard B306 GLIC-ELIC CHIMERAS HAVE UNEXPECTED CHARACTERISTICS. Sarah C. Lummis , Mona Alqazzaz 2170-P os B oard B307 ROLE OF THE TRANSMEMBRANE α -HELIX M4 IN THE POTENTIATION OF PENTAMERIC LIGAND-GATED ION CHANNELS. Camille M. Hénault , Casey L. Carswell, Sruthi Murlidaran, JP Daniel Therien, Peter F. Juranka, Julian A. Surujballi, Grace Brannigan, John E. Baenziger

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland