Biophysical Society 59th Annual Meeting Program Guide

8:15 am –10:15 am , B allroom III Platform Voltage-gated Na and Ca Channels

Wednesday, February 11 8:00 am –11:00 am , R oom 318 New Council Meeting 8:00 am –3:00 pm , H all C Poster Viewing 8:15 am –10:15 am , B allroom I Symposium Membrane Trafficking Chair Kerney Jebrell Glover, Lehigh University 2467-S ymp 8:15 am PROBING THE STRUCTURE, TOPOLOGY, AND OLIGOMERIZATION OF CAVEOLIN-1. Kerney Jebrell Glover 2468-S ymp 8:45 am PHO85/CDK5 IS A POSITIVE REGULATOR OF PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE VIA DIRECT PHOSPHORYLATION OF FAB1/PIKFYVE. Natsuko Jin, Lois Weisman 2469-S ymp 9:15 am DYNAMIN AT THE BRINK OF FISSION. Jenny E. Hinshaw , Anna C. Sundborger, Shunming Fang, Jurgen A. Heymann, Pampa Ray, Joshua S. Chappie 2470-S ymp 9:45 am STUDYING MEMBRANE FUSION AT THE MOLECULAR LEVEL USING A BIOMIMETIC MODEL SYSTEM. Alexander Kros 8:15 am –10:15 am , B allroom II Symposium Nanopores: Methods and Mechanistic Insights Chair Zuzanna Siwy, University of California, Irvine 2471-S ymp 8:15 am POLYMERS THROUGH PROTEIN PORES: SINGLE-MOLECULE EXPERIMENTS WITH NUCLEIC ACIDS, POLYPEPTIDES AND POLYSACCHARIDES. Hagan Bayley 2472-S ymp 8:45 am MOLYBDENUM DISULFIDE NANOPORES: WHY 3 ATOMS ARE BETTER THAN ONE? Aleksandra Radenovic 2473-S ymp 9:15 am REAL-TIME SHAPE DETERMINATION AND 5-D FINGERPRINTING OF SINGLE PROTEINS. Michael Mayer 2474-S ymp 9:45 am PORES WITH UNDULATING DIAMETER FOR MULTIPRONGED CHARACTERIZATION OF SINGLE PARTICLES AND CELLS IN RESISTIVE-PULSE TECHNIQUE. Zuzanna S. Siwy , Laura Innes, Matthew Schiel, Ivan Vlassiouk, Kenneth J. Shea, Luke Theogarajan

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Co-Chairs Jon Silva, Washington University in St. Louis Bonnie Wallace, Birkbeck College, University of London, United Kingdom 2475-P lat 8:15 am SODIUM ION COORDINATION IN THE SELECTIVITY FILTER OF A VOLTAGE-GATED SODIUM CHANNEL. Claire E. Naylor , Claire Bagneris, Paul G. DeCaen, David E. Clapham, B.A. Wallace 2476-P lat 8:30 am CONDUCTION AND SELECTIVITY IN NA+ CHANNELS ANALYZED BY BIAS-EXCHANGE METADYNAMICS SIMULATIONS. Simone Furini , Paolo Barbini, Carmen Domene 2477-P lat 8:45 am INACTIVATION VOLTAGE SENSOR S4 IN DOMAIN IV OF NAV1.2 CONTROLS IMMOBILIZATION OF S4 IN DOMAIN III AS SHOWN BY OMEGA CURRENTS. Nikolaus G. Greeff , Claudia Lehmann, Hansjakob Heldstab 2478-P lat 9:00 am AUTOSOMAL RECESSIVE INHERITANCE OF CONGENITAL MYASTHENIC SYNDROME IS ASSOCIATED WITH SKELETAL MUSCLE SODIUM CHANNEL MUTATIONS. Karima Habbout, Serena Guiliano, Hugo Poulin, Damien Sternberg, Bruno Eymard, François Rivier, Raul Juntas Morales, Mohamed Chahine, Sophie Nicole, Saïd Bendahhou 2479-P lat 9:15 am OPTICAL TRACKING OF NAV1.5 CONFORMATION REVEALS MOLECULAR MECHANISMS β 1 SUBUNIT REGULATION. Wandi Zhu , Eric J. Hsu, Angela R. Schubert, Zoltan Varga, Jonathan R. Silva 2480-P lat 9:30 am LIVE-CELL IMAGING OF MIDCHANNEL PROTEOLYSIS OF NEURONAL SURFACE L-TYPE CALCIUM CHANNELS. Ioannis E. Michailidis , Dan Zhang, Jian Yang 2481-P lat 9:45 am MECHANISMS OF AUXILIARY α 2 δ -1 SUBUNIT REGULATION OF VOLTAGE-GATED CALCIUM CHANNELS. Sihui Ma , Henry

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M. Colecraft 2482-P lat

10:00 am TOWARDS A COMMON STRUCTURE-FUNCTION

FRAMEWORK FOR CALMODULIN REGULATION OF CALCIUM AND SODIUM CHANNELS. Manu B. Johny , Paul J. Adams, Billy Kang, David T. Yue

8:15 am –10:15 am , B allroom IV Platform Optical Spectroscopy: CD, UV-VIS, Vibrational, Fluorescence

Co-Chairs Richard Thompson, University of Maryland Rudra Kafle, University of Michigan 2483-P lat 8:15 am

RATIOMETRIC BIOLUMINESCENCE-BASED ZINC BIOSENSOR WITH NANOMOLAR SENSITIVITY. Evgenia G. Matveeva, Graham Franke, Leslie Bourne, Andrea K. Stoddard, Carol A. Fierke, Richard B. Thompson

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland