Biophysical Society 59th Annual Meeting Program Guide

2935-P os B oard B365 A PQ-CHANNEL MUTATION ASSOCIATED WITH EPILEPSY ALTERS THE VOLTAGE DEPENDENCE OF CHANNEL INACTIVATION. Ellie Dubrovina, Gabrielle Suppa, Keith Thomas, Zafir Buraei 2936-P os B oard B366 cpow travel awardee β 2A AND β 3 DIFFERENTIALLY MODULATE TIME- AND VOLTAGE-DEPENDENT PROPERTIES OF INDIVIDUAL VOLTAGE SENSORS IN THE HUMAN CAV1.2 CHANNEL. Nicoletta Savalli , Daniel Sigg, Alan Neely, Riccardo Olcese 2937-P os B oard B367 THE α 2 δ SUBUNIT EFFICIENTLY COUPLES VSDS ACTIVATION TO PORE OPENING IN HUMAN CAV1.2 CHANNELS. Nicoletta Savalli , Antonios Pantazis, Daniel Sigg, Alan Neely, Riccardo Olcese 2938-P os B oard B368 cpow travel awardee GENETIC ABLATION OF KLHL1 ALTERS CAV3.2 EXPRESSION IN DRG NEURONS AND MECHANICAL PAIN TRANSMISSION. Elizabeth Martinez-Hernandez , Yungui He, Paula P. Perissinotti, Erik Almazan, Michael D. Koobb, Erika S. Piedras-Renteria 2939-P os B oard B369 MORPHOLINO OLIGOMER PEPTIDE THERAPY IMPROVES MITOCHONDRIAL FUNCTION IN MDX CARDIOMYOPATHY. Victoria P. Johnstone, Abbie M. Adams, Steve D. Wilton, Sue Fletcher, Livia C. Hool 2940-P os B oard B370 HIGH SUSCEPTIBILITY TO NON-ALCOHOLIC FATTY LIVER DISEASE IN TWO-PORE CHANNEL 2-DEFICIENT MICE. Christian Grimm, Cheng-Chang Chen, Elisabeth Butz, Martin Biel, Christian Wahl-Schott Ion Channels, Pharmacology, and Disease (Boards B371-B400) 2941-P os B oard B371 RELEVANCE OF SARS-COV E PROTEIN ION CHANNEL ACTIVITY IN VIRUS PATHOGENESIS. Carmina Verdiá Báguena , José L. Nieto-Torres, Marta L. De Diego, Jose M. Jimenez-Guardeño, Jose A. Regla-Nava, Raul Fernandez-Delgado, carlos Castaño-Rodríguez, Jaume Torres, Antonio Alcaraz, Vicente M. Aguilella, Luis Enjuanes 2942-P os B oard B372 DIVALENT COPPER COMPOUND AS INHIBITORY AGENT OF INFLUENZA A. Kelly L. McGuire , Nathan A. Gordon, Roger G. Harrison, David D. Busath 2943-P os B oard B373 INSIGHTS ON MOLECULAR DETERMINANTS OF HERG K + CHANNEL INHIBITION: DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF LUBELUZOLE DERIVATIVES. Roberta Gualdani , Maria Maddalena Cavalluzzi, Francesco Tadini-Buoninsegni, Maria Rosa Moncelli, Giovanni Lentini 2944-P os B oard B374 VALIDATION OF KCA3.1 CHANNEL NIFEDIPINE INTERACTION SITE PREDICTED BY ROSETTA MODELING METHOD. Hai M. Nguyen , Heike Wulff, Vladimir Yarov-Yarovoy 2945-P os B oard B375 GBR-12909: POTENT BLOCKER OF PEAK AND LATE NAV1.5 CURRENTS. Carlos Obejero-Paz , James Kramer, Andrew Bruening- Wright, Antonio Lacerda, Arthur Brown

2946-P os B oard B376 VX-770 AND NPPB MODULATE CFTR GATING VIA DIFFERENT BUT DEPENDENT MECHANISMS. Wen Ying Lin , Kangyang Jih, Tzyh-chang Hwang 2947-P os B oard B377 “USE DEPENDENCE” WITHOUT A BALL AND CHAIN - INHIBITION OF BACTERIAL SODIUM CHANNELS BY μ-CONTOXINS. Rocio K. Finol-Urdaneta, Denys McMaster, Robert J. French 2948-P os B oard B378 W493R GAIN OF FUNCTION MUTATION IN ATYPICAL CYSTIC FIBROSIS REWIRES THE EPITHELIAL SODIUM CHANNEL DYNAMICS. Mahmoud Shobair , Yan H. Dang, Hong He, Jack M. Stutts, Nikolay V. Dokholyan 2949-P os B oard B379 ROLE OF THREONINE 338 IN CFTR GATING. Hsuan-Ting Kuo , Tzyh-Chang Hwang 2950-P os B oard B380 PP1 ANCHORING ONTO NCX1 FACILITATES DEPHOSPHORYLATION OF P-SER68-PLM. Tandekile Lubelwana Hafver , Pimthanya Wanichawan, Kjetil Hodne, Jan Magnus Aronsen, Bjørn Dalhus, Marianne Lunde, Ulla Enger, Marita Mathisen, William Fuller, Ivar Sjaastad, Ole Sejersted, Cathrine Carlson 2951-P os B oard B381 THE PORE-DOMAIN OF TRPA1 MEDIATES THE INHIBITORY EFFECT OF THE ANTAGONIST 6-METHYL-5-(2- (TRIFLUOROMETHYL)PHENYL)-1H-INDAZOLE. Hans Moldenhauer , Ramon Latorre, Jorg Grandl 2952-P os B oard B382 PLANAR PATCH CLAMP SYSTEM CAPABLE OF RECORDING MECHANOSENSITIVE ACTIVITY OF ION CHANNELS. Ken Takahashi , Keiji Naruse 2953-P os B oard B383 SINGLE-CHANNEL ANALYSIS OF THE MOLECULAR PHARMACOLOGY OF THE LONG QT SYNDROME VARIANT 3. Seth H. Robey , Kevin J. Sampson, Robert S. Kass 2954-P os B oard B384 AUTOMATED PATCH-CLAMP PHARMACOLOGY ASSAYS USING HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES. Olaf Scheel, Stefanie Frech, Bogdan P. Amuzescu , Jörg Eisfeld, Kun-Han Lin, Thomas Knott 2955-P os B oard B385 PHARMACOLOGICAL CHARACTERIZATION OF NR1/ NR2A AND NR1/NR2B GLUTAMATE RECEPTORS USING AN ELECTROPHYSIOLOGY BASED HTS ASSAY. Nikolai Fedorov , Yuri Kuryshev, Amy Wright, Zhiqi Liu, Luke Armstrong, Glenn E. Kirsch, Arthur M. Brown 2956-P os B oard B386 CHARACTERIZATION OF SMALL MOLECULE MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR USING BACKSCATTERING INTERFEROMETRY. Ashley Lockwood , David Heidary, Christopher Richards, Michael Baksh, M.G. Finn 2957-P os B oard B387 DANTROLENE INHIBITION OF RYR2 REQUIRES CALMODULIN. Ye W. Oo , N Gomez-Hurtado, D.F. vanHelden, M. S Imtiaz, B.C Knollmann, D.R Laver

W E

D N

E S

D A Y

169

Biophysical Society 59 th Annual Meeting, Baltimore, Maryland