Biophysical Society 59th Annual Meeting Program Guide

271-P os B oard B51 THERMODYNAMIC PROPERTIES OF ELP-LABELLED DOXORUBICIN, A DRUG DELIVERY SYSTEM. Valeria Zai-Rose 272-P os B oard B52 UNDERSTANDING THE FUNCTION OF A PRO-ANGIOGENIC POLYPEPTIDE HFGF-1 WITH A CANCER INHIBITOR IMATINIB. Tulsi Modi , Oluwadamilola Filani, Jason Payne, Raja Murthy 273-P os B oard B53 A SHARED BINDING SITE FOR PROPOFOL AND THIOPENTAL IN ELIC. Monica N. Kinde , Weiming Bu, Edom Seyoum, Qiang Chen, Marta M. Wells, David D. Mowrey, Roderic G. Eckenhoff, Yan Xu, Pei Tang 274-P os B oard B54 CRYSTAL VIEW OF ANESTHETICS AND ALCOHOLS BOUND IN THE PORE OF ELIC. Qiang Chen , Monica N. Kinde, Aina E. Cohen, Pei Tang, Yan Xu 275-P os B oard B55 ANALYSIS OF ANTIFOLATE DRUGS WITH DISEASE TISSUE SPECIFICITY. Siobhan M. Deis , Charles E. Dann III 276-P os B oard B56 PKA-DEPENDENT POTENTIATION MECHANISMS OF HUMAN CFTR ACTIVITY. Guangyu Wang 277-P os B oard B57 KINASE STRUCTURAL DYNAMICS ENABLES TIGHT AND SELECTIVE BINDING OF INHIBITORS. Roman V. Agafonov , Chris Wilson, Vanessa Buosi, Renee Otten, Dorothee Kern 278-P os B oard B58 education travel awardee cpow mid - career travel awardee GLUTATHIONE REDUCTASE OF PLASMODIUM FALCIPARUM AS AN ANTIMALARIAL DRUG TARGET OF METHYLENE BLUE. Socheata Lim , Judith H. Prieto 279-P os B oard B59 EFFECTS OF MOLECULAR CROWDING ON THE BINDING AFFINITY OF DIHYDROFOLATE FOR DIHYDROFOLATE REDUCTASE. Michael R. Duff , Elizabeth E. Howell 280-P os B oard B60 QUANTIFYING THE INFLUENCE OF THE CROWDED CYTOPLASM ON SMALL BIOMOLECULE DIFFUSION VIA HOMOGENIZATION THEORY. Peter M. Kekenes-Huskey , Caitlin E. Scott 281-P os B oard B61 SPECIFIC OR GENERAL - IT IS ALL ABOUT SOLUTE INTERACTIONS WITH THE PORE. Ekaterina M. Nestorovich , Sergey M. Bezrukov 282-P os B oard B62 USING SEDIMENTATION VELOCITY TO INVESTIGATE THE NUCLEOTIDE-LINKED ASSEMBLY OF E. COLI CLPA. Ryan P. Stafford , Aaron L. Lucius 283-P os B oard B63 MACROMOLECULAR CROWDER AND LIGAND COMPETE FOR THE CLOSED DOMAIN CLEFT OF MALTOSE BINDING PROTEIN. Archishman Ghosh , Huan-Xiang Zhou

284-P os B oard B64 CHARACTERIZATION OF THE CALCIUM-BINDING AND PEPTIDE-BINDING PROPERTIES OF ARRHYTHMOGENIC CALMODULIN MUTANTS. Shane D. Walton , Norma M. Elizaga, Hsiang-Ting Ho, Jalal K. Siddiqui, Andrew J. O’Neil, Bin Liu, Sandor Gyorke, Jonathan P. Davis 285-P os B oard B65 LIPOYLATION MECHANISM OF P. FALCIPARUM MITOCHONDRIAL PROTEINS. Alfredo J. Guerra , Gustavo A. Afandor, Russell P. Swift, Sean T. Prigge 286-P os B oard B66 UNDERSTANDING THE MOLECULAR DETERMINANTS OF CAPSAICIN MODE OF ACTION. Khaled M. Elokely , Eugene Palovack, Lucie Delemotte, Vincenzo Carnevale, Michael L. Klein Protein Dynamics and Allostery I (Boards B67-B88) 287-P os B oard B67 FORMATION AND DEGRADATION OF INTERMEDIATE HEMOGLOBIN POLYMERS ARE RESPONSIBLE FOR THE COOPERATIVITY OF OXYGEN BINDING ISOTHERMS. Enrico Bucci , Stefania Pucciarelli, Mauro Angeletti 288-P os B oard B68 ROLE OF IONIC STRENGTH AND THE BOHR EFFECT IN MODULATING THERMODYNAMIC PROFILES ASSOCIATED WITH CO ESCAPE IN RICE NON-SYMBIOTIC HEMOGLOBIN 1. David Butcher , Jaroslava Miksovska 289-P os B oard B69 THE “CAGED” STATE, THE TRANSITION STATE OF THE REGULATION OF OXYGEN-AFFINITY IN HEMOGLOBIN. Takashi Yonetani , Kenji Kanaori 290-P os B oard B70 UNDERSTANDING THERMODYNAMICS OF CONFORMATIONAL CHANGE IN THE F-ATPASE. Nicholas Leioatts , Helmut Grubmüller 291-P os B oard B71 KINETIC CONTROL OF O2 REACTIVITY IN H-NOX DOMAINS. Abdelkrim Benabbas , Yuhan Sun, Weiqiao Zeng, Sandhya Muralidharan, Elizabeth Boon, Paul Champion 292-P os B oard B72 PROBING FLEETING INTERACTIONS IN LARGE AND DYNAMIC NONRIBOSOMAL PEPTIDE SYNTHETASES WITH NOVEL NMR METHODS. Dominique P. Frueh , Andrew C. Goodrich, Bradley J. Harden, Scott R. Nichols, Subrata H. Mishra 293-P os B oard B73 education travel awardee VISUALIZING THE INTER-DOMAIN MOTIONS OF A PATHOGENIC PROTEIN USING SPARSE RDC DATA. Yang Qi , Jeffrey W. Martin, Anthony Yan, Francois Thelot, Bruce R. Donald, Terrence G. Oas 294-P os B oard B74 MAPPING THE CONFORMATIONAL DYNAMICS OF THE SCAFFOLD PROTEIN PSD-95. Claus A.M. Seidel , Jakub Kubiak, Suren Felekyan, Daniel Rohrbeck, James J. McCann, Mark E. Bowen

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland