Biophysical Society 59th Annual Meeting Program Guide

539-P os B oard B319 ELECTRON-CONFORMATIONAL TRANSFORMATIONS IN NANOSCOPIC RYR2 CHANNELS GOVERN BOTH THE HEART’S CONTRACTION AND BEATING. Alexander Moskvin , Alexander Ryvkin, Nikolay Zorin, Kirill Soulim, Bogdan Yaparov, Olga Solovyova, Vladimir Markhasin 540-P os B oard B320 MG56, A MEMBER OF THE MBOAT FAMILY OF PROTEINS, REGULATES INTRACELLULAR CALCIUM SIGNALING IN STRIATED MUSCLE. Matthew Sermersheim , Xinyu Zhou, Ki Ho Park, Pei-Hui Lin, Jacob Yount, Wayne Chen, Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma 541-P os B oard B321 CISPLATIN-INDUCED CACHEXIA IN RATS CAUSES ALTERATIONS IN SKELETAL MUSCLE CALCIUM HOMEOSTASIS. Elena Conte, Adriano Fonzino, Sabata Pierno, Giulia Maria Camerino, Maria Cannone, Kejla Musaraj, Laura Rizzi, Elena Bresciani, Antonio Torsello, Diana Conte, Antonella Liantonio 542-P os B oard B322 STIM1 ENHANCES SR CA 2+ CONTENT THROUGH INHIBITING PHOSPHOLAMBAN IN RAT VENTRICULAR MYOCYTES. Guiling Zhao , Didier X. P. Brochet, Tianyu Li, Paul Rosenberg, W. Jonathan Lederer 543-P os B oard B323 REGULATION OF CALCINEURIN BY CALCIUM-BINDING COUSINS. Lisa D. Weaver, Brandon R. Uribe, Maria F. Núñez Hernandez, Michael C. Rendleman, Sean A. Klein, Susan E. O’Donnell, Madeline A. Shea 544-P os B oard B324 IDENTIFY THE BINDING INTERFACE BETWEEN CALSENILIN AND PRESENILIN 1 C-TERMINAL FRAGMENT. Khoa N. Pham , Jaroslava Miksovska 545-P os B oard B325 ROLE OF MITOCHONDRIAL CA 2+ UNIPORTER IN RADIATION- INDUCED CELL DAMAGE. Xibao Liu , Baijuan Gong, Hwei Ling Ong, Kwong Tai Cheng, Madesh Muniswamy, Indu S. Ambudkar 546-P os B oard B326 DIVERSITY OF MITOCHONDRIAL CA ( 2+ ) SIGNALING: EVIDENCE FROM GENETICALLY ENCODED PROBES. Xiaohua Zhang , Naohiro Yamaguchi, Lars Cleemann, Martin Morad 547-P os B oard B327 ANALYSIS OF ATP PRODUCTION EFFICIENCY OF BEAT- TO-BEAT CALCIUM FLUCTUATIONS IN CARDIAC MITOCHONDRIA. Sangeeta Shukla , W. Jonathan Lederer, M. Saleet Jafri 548-P os B oard B328 IN VIVO TEMPERATURE SENSITIVITY OF THE CALCIUM AFFINITY OF FLUO-5F AND MAG-FLUO4. Brian M. Hagen , Joseph P.Y. Kao, W, Jonathan Lederer 549-P os B oard B329 A NOVEL RED FLUORESCENCE CALCIUM INDICATOR FOR FUNCTIONAL ANALYSIS OF GPCRS AND CALCIUM CHANNEL TARGETS. Qin Zhao, Haitao Guo, George Yi, Jinfang Liao , Zhenjun Diwu 550-P os B oard B330 COUPLING INTERACTIONS OF THE DIMERIC SOAR UNIT OF STIM1 WITH ORAI1 CHANNELS. Yandong Zhou , Xizhuo Wang, Xianming Wang, Natalia A. Loktionova, Xiangyu Cai, Xiangyu Cai, Youjun Wang, Donald L. Gill

551-P os B oard B331 TRANSLOCATION BETWEEN PI(4,5)P 2

-POOR AND PI(4,5)

P 2 -RICH MICRODOMAINS DURING STORE DEPLETION DETERMINES STIM1 CONFORMATION AND GATING OF ORAI1. Shmuel Muallem , Jozsef Maléth, Seok Choi, Malini Ahuja Cardiac, Smooth, and Skeletal Muscle Electrophysiology I (Boards B332-B347) 552-P os B oard B332 DIFFERENTIAL EFFECTS OF ANTIARRHYTHMIC DRUGS VERNAKALANT AND FLECAINIDE ON HUMAN TWO-PORE- DOMAIN K + CHANNELS. Dierk Thomas , Claudia Seyler, Patrick A. Schweizer, Hugo A. Katus 553-P os B oard B333 CLASSIFYING THE ELECTROPHYSIOLOGICAL EFFECTS OF CHRONOTROPIC DRUGS ON HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES USING VOLTAGE SENSITIVE DYES AND SUPERVISED MACHINE LEARNING. Christopher M. Heylman , Rupsa Datta, Bruce R. Conklin, Steven C. George, Enrico Gratton 554-P os B oard B334 SPARFLOXACIN, A FLUOROQUINOLONE ANTIBIOTIC, SLOWS INACTIVATION OF L-TYPE CA 2+ CURRENT IN NEONATAL RAT VENTRICULAR MYOCYTES. Jae Gon Kim , Sang Woong Park, Hun Ji Kim, Hana Cho, Young Min Bae 555-P os B oard B335 ON-CHIP QUASI- IN VIVO PREDICTIVE CARDIOTOXICITY ASSAY USING SPATIOTEMPORAL FLUCTUATION MEASUREMENT ON HUMAN CARDIOMYOCYTE CELL- NETWORK. Fumimasa Nomura , Tomoyuki Kaneko, Hideyuki Terazono, Kenji Yasuda 556-P os B oard B336 LABEL-FREE HIGH-THROUGHPUT CARDIOTOXICITY ASSAYS USING COMBINED IMPEDANCE AND EXTRACELLULAR FIELD POTENTIAL MEASUREMENTS. Corina T. Bot, Sonja Stoelzle-Feix, David R. Guinot, Ulrich Thomas, Ulrich Thomas, Leo Doerr, Matthias Beckler, George Okeyo, Joerg Oestreich, Rodolfo J. Haedo , Michael George, Niels Fertig 557-P os B oard B337 A NOVEL CLASSIFICATION METHOD WITH SUPERIOR PREDICTION OF DRUG ARRHYTHMIA RISK. Megan A. Cummins , Eric A. Sobie 558-P os B oard B338 ELECTROPHYSIOLOGY OF CARDIAC TISSUE SLICES BEFORE, DURING, AND AFTER STRETCH. Ken Wang, Razik Mu-u-min, Derek Terrar, David GJ Gavaghan, Peter Kohl, Christian Bollensdorff 559-P os B oard B339 DUAL SPIKES OF CATECHOLAMINE RELEASES FROM SYMPATHETIC NERVES IN RODENT HEART SLICES FOLLOWING HYPOXIA-REPERFUSION AS RECORDED BY A NOVEL ELECTROCHEMICAL METHOD. Bing Liu, Shu Guo, Jing L ǚ , Xinjiang Kang, Yun Xiu, Jingli Gu, Yu Mu, Qian Lei, Bin Liu, Kun Liu, Lihuan Li, Changhe Wang, Jimin Cao, Zhuan Zhou 560-P os B oard B340 ELECTRONIC EXPRESSION OF IK1 IN HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOCYTES REVEALS ATRIAL VS VENTRICULAR SPECIFIC PROPERTIES. Aaron D. Kaplan, Glenna C.L. Bett, Randall L. Rasmusson

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland