Biophysical Society 59th Annual Meeting Program Guide

708-P os B oard B488 PERSISTENT ACTIVATION OF SIGNAL TRANSDUCTION NETWORKS INDUCES A NOVEL MECHANISM OF CELL DEATH. Marc Edwards , Huaqing Cai, Peter Devreotes 709-P os B oard B489 ACUTE MECHANICAL STIMULATION ACTIVATES THE CHEMOTACTIC SIGNALING NETWORK. Yulia Artemenko , Jane S. Borleis, Peter N. Devreotes 710-P os B oard B490 PHARMACOLOGICAL ACTIVATION OF MYOSIN II TO CORRECT PANCREATIC CANCER CELL MECHANICS. Alexandra Surcel , Qingfeng Zhu, Eric Schiffhauer, Robert Anders, Douglas Robinson 711-P os B oard B491 SH3 DOMAIN OF C-SRC REGULATES ITS DYNAMIC BEHAVIOR IN THE CELL MEMBRANE. Hiroaki Machiyama , Tomoyuki Yamaguchi, Tomonobu M. Watanabe, Hideaki Fujita 712-P os B oard B492 INSIGHTS ON RGD-BASED PEPTIDE INTERACTIONS WITH INTEGRIN RECEPTORS FROM ATOMISTIC SIMULATIONS. Aravind Rammohan , Jacob Miner, Matthew Mckenzie 713-P os B oard B493 H2-CALPONIN GENE KNOCKOUT INCREASES TRACTION FORCE OF MOUSE FIBROBLASTS IN VITRO. M Moazzem Hossain , Guangyi Zhao, Moon-Sook Woo, James H-C. Wang, J.p. Jin 714-P os B oard B494 education travel awardee DELETION OF H2-CALPONIN IN MACROPHAGES FACILITATES CELL MOTILITY AND LIPID CLEARANCE: A NOVEL MECHANISM TO ATTENUATE ARTERIAL ATHEROSCLEROSIS. Rong Liu , Jian-Ping Jin Membrane Pumps, Transporters, and Exchangers I (Boards B495-B515) 715-P os B oard B495 ARRAYED LIPID MEMBRANES ON FEMTOLITER CHAMBERS ALLOW HIGHLY SENSITIVE DETECTION OF ION TRANSLOCATION CATALYZED BY TRANSPORTER PROTEIN. Rikiya Watanabe , Naoki Soga, Hiroyuki Noji 716-P os B oard B496 VOLTAGE DEPENDENT CONFORMATIONAL CHANGES OF THE NA + /K + -ATPASE REVEALED BY SITE DIRECTED FLUOROMETRY. Jorge E. Sánchez-Rodríguez , Pablo Miranda- Fernández, Miguel Holmgren, Francisco Bezanilla 717-P os B oard B497 NA + /K + -ATPASE PUMPING MECHANISM: INSIGHTS FROM SIMULATIONS. Huan Rui , Avisek Das, Benoit Roux 718-P os B oard B498 TOWARDS THERMODYNAMIC CHARACTERIZATION OF TRANSPORT CYCLE IN SECONDARY TRANSPORTERS USING ENHANCED SAMPLING TECHNIQUES. Mahmoud Moradi , Giray Enkavi, Emad Tajkhorshid 719-P os B oard B499 PROTONATION STATES OF KEY ACIDIC RESIDUES AT THE ION BINDING SITES IN NA/K PUMP BY QM CALCULATIONS. Naoki Tsunekawa , Chikashi Toyoshima

720-P os B oard B500 education travel awardee NA + /K + PUMP ION BINDING SITE INTERACTIONS REGULATE THE PROTON LEAK PATHWAY. Kevin Stanley , Craig Gatto, Pablo Artigas 721-P os B oard B501 POTASSIUM REGULATION OF THE NAK-ATPASE PUMP

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CURRENTS IN MAMMALIAN SKELETAL MUSCLE FIBERS. Marino G. Di Franco , Jerry Lingrel, Judith Heiny 722-P os B oard B502 A COMBINATION OF CURCUMIN WITH EITHER

GRAMICIDIN OR OUABAIN SELECTIVELY KILLS CELLS THAT EXPRESS THE MULTIDRUG RESISTANCE-LINKED ABCG2 TRANSPORTER. Haiyan Liu , Divya K. Rao, Suresh V. Ambudkar, Michael Mayer 723-P os B oard B503 education travel awardee CONFORMATIONAL CHANGES AND COMPLEX FORMATION OF THE NON-CANONICAL RIBOSE ABC TRANSPORTER. Satchal K. Erramilli , Cynthia V. Stauffacher 724-P os B oard B504 MOVEMENT OF THE NUCLEOTIDE BINDING DOMAINS IN THE ABC TRANSPORTER MSBA RECONSTITUTED IN NANODISCS. Maria E. Zoghbi , Guillermo A. Altenberg 725-P os B oard B505 MULTISCALE QM/MM SIMULATIONS OF ATP HYDROLYSIS MECHANISM IN ABC-TRANSPORTERS. Jingzhi Pu 726-P os B oard B506 education travel awardee RECONSTITUTION OF MULTIDRUG RESISTANCE EFFLUX PUMPS IN GIANT LIPOSOMES. SooHyun Park , You Jung Kang, Sheereen Majd 727-P os B oard B507 EXPLORING P-GLYCOPROTEIN SUBSTRATE ACCESS. Laura Domicevica , Philip C. Biggin 728-P os B oard B508 METHIONINE IMPORTERS IN SOIL BACTERIA: POTENTIAL FOR TRANSPORTER-COMPONENT CROSSTALK. Eliza Zielazinski , Sarah Zerbs, Peter Larsen, Frank Collart, Philip D. Laible 729-P os B oard B509 EPR ACCESSIBILITY MEASUREMENTS OF THE SERCA-PLB COMPLEX USING SITE-DIRECTED SPIN LABELING. Peter D. Martin , Zachary M. James, Jesse E. McCaffrey, Dave D. Thomas 730-P os B oard B510 MAPPING OF SARCOLIPIN CONFORMATIONAL STATES ALONG THE ENZYMATIC PATHWAY OF SERCA. Alysha A. Dicke , Kaustubh R. Mote, Gianluigi Veglia 731-P os B oard B511 USING A LIVE-CELL HIGH-THROUGHPUT TIME-RESOLVED FRET ASSAY TO DISCOVER ENZYME MODULATORS. Ji Li , Tory M. Schaaf, Simon J. Gruber, Razvan L. Cornea, Joseph M. Autry, Samantha L. Yuen, Ryan Chen, Kurt C. Peterson, Gregory D. Gillispie, David D. Thomas 732-P os B oard B512 MOLECULAR DYNAMICS SIMULATIONS OF CALCIUM PUMP STRUCTURAL DISORDER. Nikolai Smolin , Seth Robia

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland