Biophysical Society 60th Annual Meeting

1458-Pos Board B435 STRUCTURAL AND BIOCHEMICAL KINETICS OF CARDIAC MYOSIN AND ITS PERTURBATION BY A KNOWN HEART FAILURE DRUG INVESTIGATED WITH TRANSIENT TIME-RESOLVED FRET.  John A. Rohde , David D. Thomas, Joseph M. Muretta 1459-Pos Board B436 OMECAMTIV MECARBIL ENHANCES ACTIN AFFINITY AND SLOWS FORCE PRODUCTION IN HUMAN β-CARDIAC MYOSIN. Anja M. Swenson, Cheavar Blair, Christopher Fetrow, William C. Unrath, Wanjian Tian, Maya Guglin Guglin, Kenneth S. Campbell, Christopher M. Yengo 1460-Pos Board B437 EFFECT OF RLC N-TERMINAL TAILS ON THE STRUCTURE AND DYNAMICS OF CARDIAC MYOSIN. Arianna Fornili , Elena Rostkova, Franca Fraternali, Mark Pfuhl 1461-Pos Board B438 CARDIOMYOPATHY MUTATION IN VENTRICULAR ESSENTIAL LIGHT CHAIN OF CARDIAC MYOSIN ALTERS STRUCTURAL AND FUNCTIONAL INTERAC- TION WITH ACTIN. Piyali Guhathakurta , Ewa Prochniewicz, David D. Thomas 1462-Pos Board B439 EFFECTS OF MYOSIN LIGHT CHAIN PHOSPHORYLATION ON LENGTH-DE- PENDENT MYOSIN KINETICS IN RAT CARDIAC VENTRICLES. Bertrand CW Tanner , Hannah C. Pulcastro, Peter O. Awinda, Jason J. Breithaupt 1463-Pos Board B440 EFFECTS OF IVS6-1 MUTATION IN MYL2 ASSOCIATED WITH CARDIOSKEL- ETAL MYOPATHY AND EARLY CARDIAC DEATH OF INFANTS. Zhiqun Zhou , Wenrui Huang, Jingsheng liang, Danuta Szczesna-Cordary 1464-Pos Board B441 RARE CARDIOMYOPATHY PHENOTYPES ASSOCIATED WITH MUTATIONS IN MYOSIN LIGHT CHAINS. Chen-Ching Yuan , Jingsheng Liang, Katarzyna Kazmierczak, Zhiqun Zhou, Rosemeire Kanashiro-Takeuch, Joshua M. Hare, Thomas C. Irving, Danuta Szczesna-Cordary 1465-Pos Board B442 UPREGULATING COMPLIANT TITIN IN THE HEART ATTENUATES LEFT VEN- TRICULAR STIFFNESS IN A MOUSE MODEL WITH DIASTOLIC DYSFUNC- TION. Mei Methawasin , Joshua G. Strom, Vanessa Fernandez, Chandra Saripalli, John E. Smith III, Henk L. Granzier 1466-Pos Board B443 EXERCISE MITIGATES INCREASED DIASTOLIC STIFFNESS IN THE TITIN IA KO MOUSE. Rebecca E. Slater , Mei Methawasin, Josh Strom, Chandra Saripalli, Henk L. Granzier 1467-Pos Board B444 A NOVEL ROLE FOR PP5 IN REGULATING TITIN PHOSPHORYLATION AND FUNCTION IN THE HEART. Judith Krysiak, Andreas Unger, Nazha Hamdani, Peter Boknik, Wolfgang A. Linke Skeletal Muscle Mechanics, Structure, and Regulation (Boards B445 - B469) 1468-Pos Board B445 COMPLIANCE ACCELERATES RELAXATION IN STRIATED MUSCLE BY ALLOWING MYOSIN HEADS TO MOVE RELATIVE TO ACTIN. Kenneth S.

1446-Pos Board B423 MATURATION TOWARDS PURE β-MYOSIN PROTEIN EXPRESSION AND CORRESPONDING FUNCTIONAL PROPERTIES OF INDIVIDUAL HESC- CARDIOMYOCYTES. Natalie Weber , Meike Wendland, Stephan Greten, Kristin Schwanke, Bogdan Iorga, Martin Fischer, Cornelia Geers-Knörr, Jan Hegermann, Christoph Wrede, Ulrich Martin, Bernhard Brenner, Robert Zweigerdt, Theresia Kraft 1447-Pos Board B424 A TUNED TENSION REGULATES THE CONTRACTILITY OF CARDIOMYO- CYTES DIFFERENTIATED FROM INDUCED PLURIPOTENT STEM CELLS.  Alexandre J. Ribeiro , Yen-Sin Ang, Robin E. Wilson, Renee N. Rivas, Deepak Srivastava, Beth L. Pruitt 1448-Pos Board B425 CONTRACTILE FUNCTION OF PERMEABILIZED HUMAN EMBRYONIC STEM CELL-DERIVED CARDIOMYOCYTES WITH DEFINED MYOSIN PROTEIN ISOFORM EXPRESSION. Bogdan Iorga, Meike Wendland, Natalie Weber, Stephan Greten, Kristin Schwanke, Ulrich Martin, Robert Zweigerdt, Theresia Kraft, Bernhard Brenner 1449-Pos Board B426 CROSS-BRIDGE KINETICS IN RAT PAPILLARY MUSCLE FIBERS THAT CARRY α-MHC AND β-MHC BY SINUSOIDAL ANALYSIS. Tarek S. Karam, John J. Michael, Chandra Murali, Masataka Kawai 1450-Pos Board B427 CROSSBRIDGE RECRUITMENT DYNAMICS ARE DIVERGENTLY AFFECTED BY α/β-MYOSIN HEAVY CHAIN ISOFORMS IN CARDIAC MUSCLE FIBERS CONTAINING THE HYPERTROPHIC CARDIOMYOPATHY MUTATION (A30V) AND PROTEIN KINASE C PHOSPHOMIMETIC (T203E) IN MOUSE CARDIAC TROPONIN T. Alexis Mickelson , Sampath Gollapudi, Murali Chandra 1451-Pos Board B428 INTERPLAY BETWEEN THE EFFECTS OF DILATED CARDIOMYOPATHY MU- TATION (R206L) AND THE PROTEIN KINASE C PHOSPHOMIMIC (T204E) OF RAT CARDIAC TROPONIN T ARE DIFFERENTLY MODULATED BY α- AND β-MYOSIN HEAVY CHAIN ISOFORMS.  John J. Michael , Murali Chandra 1452-Pos Board B429 THE EFFECT OF PEDIATRIC SPECIFIC HYPERTROPHIC CARDIOMYOPATHY MUTATIONS ON THE BIOMECHANICS OF BETA CARDIAC MYOSIN. Arjun S. Adhikari , Kristina Bezold Kooiker, Shirley Sutton, Daniel Bernstein, Leslie A. Leinwand, Kathleen M. Ruppel, James A. Spudich 1453-Pos Board B430 ADP-STIMULATED CONTRACTION: A PREDICTOR OF THIN-FILAMENT ACTIVATION IN CARDIAC DISEASE. Vasco Sequeira , Aref Najafi, Paul J. M. Wijnker, Cris dos Remedios, Michelle Michels, Diederik W.D. Kuster, Jolanda van der Velden 1454-Pos Board B431 CARDIAC FIBROSIS ALTERS CALCIUM SENSITIVITY AND MYOFILAMENT RE- LAXATION. Farid Moussavi-Harami , Maria V. Razumova, Stephen Farris, Galina V. Flint, Soley Olafsson, Sonette Steczina, Yuanhua Cheng Cheng, Alice W. Racca, April Stempien-Otero, Michael Regnier 1455-Pos Board B432 PRELOAD-INDUCED CHANGES IN SYSTOLIC AND DIASTOLIC PERFOR- MANCE IN THE YOUNG AND AGED MURINE HEART. Adam B. Veteto , Kerry S. McDonald, Timothy L. Domeier 1456-Pos Board B433 CID TRAVEL AWARDEE MYOCARDIUM FROM THE LEFT AND RIGHT VENTRICLES OF HUMAN HEARTS HAVE SIMILAR MECHANICAL PROPERTIES. Cheavar A. Blair , Maya E. Guglin, Arnold Stromberg, Kenneth S. Campbell 1457-Pos Board B434 EDUCATION TRAVEL AWARDEE CONTRACTILE DIFFERENCES IN LEFT AND RIGHT VENTRICLES OF HEALTHY HUMAN HEARTS. Divya Duggal , Janhavi Nagwekar, Sangram Raut, Ryan Rich, Hriday Das, Zygmunt Gryczynski, Ignacy Gryczynski, Julian Borejdo

M O N D A Y

Campbell 1469-Pos

Board B446 MYOSIN BINDING TO ACTIN IN THE 3D SARCOMERE LATTICE. Srboljub M. Mijailovich , Boban Stojanovic, Djordje Nedic, Michael A. Geeves

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