Biophysical Society 60th Annual Meeting

1:00 pm - 3:00 pm, Room 501ABC

Anna Costa, Adriaan P IJzerman, Philipp Kügler, Eugen Timin, Godfrey Smith, Steffen Hering 2598-Plat 2:30 pm SOMATIC MOSAICISM OF NOVEL SCN5A MUTATION IN PURKINJE SYSTEM (PS) MAY UNDERLIE 2:1 BLOCK IN AN INFANT WITH LONG QT SYNDROME (LQTS).  Joseph K. Yu , Patrick M. Boyle, Thomas O’Hara, James R. Priest, Euan Ashley, Natalia A. Trayanova 2599-Plat 2:45 pm THE VOLTAGE-GATED POTASSIUM CHANNEL KV1.3 AS A TARGET FOR INHIBITING DETRIMENTAL M1 MICROGLIA FUNCTIONS.  Yi-Je Chen, Hai M. Nguyen, Izumi Maezawa, Lee-Way Jin, Heike Wulff Platform Protein Plasticity & Binding 1:00 pm - 3:00 pm, Room 515B Co-Chairs Margaret Cheung, University of Houston Oliver Fisette, Ruhr-University Bochum, Germany 2600-Plat 1:00 pm A STRUCTURAL CHARACTERIZATION OF THE KV7.2-KV7.3 M CHANNEL PROXIMAL C-TERMINUS/CAM COMPLEX.  Roi Strulovich , William Tobelaim, Bernard Attali, Joel A. Hirsch 2601-Plat 1:15 pm LESSONS IN PROTEIN DESIGN FROM COMBINED EVOLUTION AND CON- FORMATIONAL DYNAMICS. Margaret S. Cheung , Swarnendu Tripathi, M. N. Waxham, Yin Liu 2602-Plat 1:30 pm IN SILICO IDENTIFICATION OF BINDING SITES RESPONSIBLE FOR SPE- CIES SPECIFICITY ON HUMAN CD81 AND HEPATITIS C VIRUS E2 PROTEIN.  Chun-Chun Chang , Hao-Jen Hsu, Je-Wen Liou 2603-Plat 1:45 pm SINGLE-MOLECULE EXPERIMENTS TO RESOLVE STRUCTURAL AND MECHANICAL PROPERTIES OF CONDENSIN.  Jorine Eeftens , Allard Katan, Marc Kschonsak, Markus Hassler, Essam Dief, Liza de Wilde, Christian Haering, Cees Dekker 2604-Plat 2:00 pm PROTEIN COMPLEXES FROMMD SIMULATIONS: THE ROPE-PULLING GAME OF TAPASIN AND HISTOCOMPATIBILITY MOLECULES.  Olivier Fisette , Lars V. Schäfer 2605-Plat 2:15 pm REMEDIAL SYNERGISTIC CONCOCTION OF β-CYCLODEXTRIN AND NATU- RALLY OCCURRING POLYPHENOLS TARGETING α-SYNUCLEIN AGGREGA- TION UNDER CELL MIMICKING CONDITIONS.  Saurabh Gautam , Pramit K. Chowdhury 2606-Plat 2:30 pm CONFORMATIONAL CHANGE IN THE ECTODOMAIN OF THE AMYLOID PRECURSOR PROTEIN IN RESPONSE TO PROTEOLYTIC PROCESSING: THE RANDOM COIL REGIONS MATTER.  Clare Peters-Libeu 2607-Plat 2:45 pm THE NON AMYLOID-β COMPONENT (NAC) OF HUMAN α-SYNUCLEIN OLIGOMERS INDUCES THE FORMATION OF NEW Aβ OLIGOMERS: INSIGHT INTO THE MOLECULAR INTERACTIONS THAT LINK PARKINSON’S DISEASE AND ALZHEIMER’S DISEASE.  Yoav Atsmon-Raz , Yifat Miller Platform Micro- and Nanotechnology

Co-Chairs Nicholas Fitzkee, Mississippi State University Meni Wanunu, Northeastern University 2608-Plat 1:00 pm

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HOW DO NANOPARTICLE SIZE AND PROTEIN CHARGE AFFECT GOLD NANOPARTICLE-PROTEIN INTERACTIONS?  Nicholas C. Fitzkee , Ailin Wang, Karen E. Woods, Randika Perera 2609-Plat 1:15 pm BIOINTERACTIONS OF ULTRASMALL GOLD NANOPARTICLES: INFLUENCE OF NANOPARTICLE SIZE AND SURFACE CHEMISTRY.  Luiza L. Knittel, Sergio A. Hassan, Maria A. Aronova, Peter Schuck, Richard D. Leapman, Alioscka A. Sousa 2610-Plat 1:30 pm TOWARDS A “GREEN” ANTIMICROBIAL THERAPY: STUDY OF GRAPHENE NANOSHEETS INTERACTION WITH HUMAN PATHOGENS.  Valentina Palmieri , Massimiliano Papi, Francesca Bugli, Mariacarmela Lauriola, Claudio Conti, Gabriele Ciasca, Giuseppe Maulucci, Maurizio Sanguinetti, Marco De Spirito 2611-Plat 1:45 pm TRACKING SINGLE-PARTICLE ROTATION DURING MACROPHAGE UPTAKE.  Lucero Sanchez , Yan Yu 2612-Plat 2:00 pm PEPTIDE TRANSLOCATION THROUGH SINGLE LYSENIN CHANNELS.  Nisha Shrestha , Sheenah Bryant, Xinzhu Pu, Paul Carnig, Juliette Tinker, Charles Hanna, Daniel Fologea 2613-Plat 2:15 pm NANOPORE ZERO-MODE WAVEGUIDES FOR DNA SEQUENCING AND BEYOND.  Joseph Larkin, Robert Y. Henley, Jonas Korlach, Meni Wanunu 2614-Plat 2:30 pm CARBON NANOTUBE PORINS: BIOMIMETIC MEMBRANE PORE CHANNELS FOR NANOFLUIDIC STUDIES.  Aleksandr Noy 2615-Plat 2:45 pm IMPROVING DNA SEQUENCING WITH NANOPORE MSPA.  Henry Brinkerhoff Platform Membrane Receptors and Signal Transduction 1:00 pm - 3:00 pm, Room 511ABC Co-Chairs Diane Lidke, University of NewMexico Christian Sieben, Humboldt-University Berlin, Germany 2616-Plat 1:00 pm THE DYNAMICS AND LOCALIZATION OF THE EPIDERMAL GROWTH FAC- TOR RECEPTOR (EGFR) ON LIVE CELL PLASMA MEMBRANE STUDIED BY ITIR-FCS.  Shuangru Huang , Nirmalya Bag, Thorsten Wohland 2617-Plat 1:15 pm PROBING THE NON-GENETIC CELL-TO-CELL HETEROGENEITY IN EGFR- MEDIATED MAPK ACTIVATION BY SUPER-RESOLUTION MICROSCOPY.  Oana Coban 2618-Plat 1:30 pm INFLUENZA A VIRUSES USE MULTIVALENT SIALIC ACID CLUSTERS FOR CELL BINDING AND RECEPTOR ACTIVATION.  Christian Sieben , Suliana Manley 2619-Plat 1:45 pm THE BINDING LIFETIME OF SYK KINASE TO THE IMMUNE RECEPTOR FCεRI

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