Biophysical Society 60th Annual Meeting

2689-Pos Board B66 MECHANISM OF UREA CONDUCTION THROUGH H. PYLORI UREI. Ugur Akgun 2690-Pos Board B67 CPOW TRAVEL AWARDEE DISSECTING THE CONTRIBUTION OF KINASE CONFORMATIONAL REOR- GANIZATION ENERGIES TO INHIBITOR SELECTIVITY. Sonya M. Hanson , Lucelenie Rodriguez, Julie M. Behr, Andrea Rizzi, Daniel L. Parton, Kyle A. Beauchamp, Joshua H. Fass, Jan-Hendrik Prinz, Sarah E. Boyce, Markus A. Seeliger, Nicholas M. Levinson, John D. Chodera 2691-Pos Board B68 MULTISCALE MODELING OF DENDRIMERS FOR BIOLOGICAL APPLICA- TIONS. Bo Wang , Esteban Gurzov, Pu Chun Ke, Feng Ding 2692-Pos Board B69 PHOSPHORYLATION MODIFIES COUPLING OF THE MEMBRANE DOMAINS AND NBD1 OF FULL LENGTH CFTR. Stephanie Chin , Mohabir Ramjeesingh, Paul Eckford, Christine E. Bear 2693-Pos Board B70 A FUSION PROTEIN OF P53 PEPTIDE AND MDMX AS AN EFFICIENT MOD- EL FOR SCREENING OF ANTICANCER PRODRUGS WITH FLUORESCENCE SPECTROSCOPY. Rong Chen, Lingyun Qin, Zheng Su Enzymes Function, Cofactors, and Post- translational Modifications (Boards B71 - B92) 2694-Pos Board B71 EDUCATION TRAVEL AWARDEE IMPULSIVE ENZYMES: A NEW FORCE IN MECHANOBIOLOGY. Krishna Kanti Dey , Ayusman Sen 2695-Pos Board B72 DISSECTING PROTON DELOCALIZATION AND THE ELECTROSTATIC CON- TRIBUTION TO CATALYSIS IN AN ENZYME’S HYDROGEN BOND NETWORK WITH UNNATURAL AMINO ACIDS. Yufan Wu , Steven G. Boxer 2696-Pos Board B73 VIBRATIONAL STARK EFFECTS FOR DIVERSE CARBONYL PROBES APPLIED TO THE RE-INTERPRETATION OF IR AND RAMAN DATA IN TERMS OF ELECTRIC FIELDS AT ENZYME ACTIVE SITES. Samuel H. Schneider , Steven G. Boxer 2697-Pos Board B74 COMPUTATIONAL STUDY ON THE CATALYTIC EFFECT OF THE MAGNESIUM IONS IN THE MECHANISM OF DNA POLYMERASES. Ricardo A. Matute , Arieh Warshel 2698-Pos Board B75 THE EFFECT OF MAGNESIUM ION CONCENTRATION ON THE NUCLEOTIDE SPECIFICITY AND FIDELITY OF HIV-1 REVERSE TRANSCRIPTASE. Shanzhong Gong , Kenneth Johnson 2699-Pos Board B76 EDUCATION TRAVEL AWARDEE THE ROLE OF PHOSPHORYLATION AND ACETYLATION OF TFAM IN DNA BINDING REGULATION USING SINGLE-MOLECULE MANIPULATION AND FLUORESCENCE MICROSCOPY. Maryam Hashemi Shabestari , Graeme A. King, Wouter H. Roos, Carolyn K. Suzuki, Gijs J. L. Wuite 2700-Pos Board B77 EDUCATION TRAVEL AWARDEE NEW INSIGHT INTO THE CATALYTIC AND INHIBITION MECHANISM OF THE HUMAN ACYL PROTEIN THIOESTERASE. Martina Audagnotto , Sylvia Ho, Patrick Sandoz, Nicole Andenmatten, Gisou van der Goot, Matteo Dal Peraro

2676-Pos Board B53 STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE INNATE IMMU- NITY ADAPTOR TIRAP. Xiaolin Zhao , Shuyan Xiao, Jeffrey Ellena, Geoffrey Armstrong, Daniel Capelluto 2677-Pos Board B54 NOVEL MODULATORS OF GLYCINE RECEPTORS. Marta M. Wells , Andrew Maxwell, Yan Xu, Pei Tang 2678-Pos Board B55 SCREENING OF A PROTEIN-PROTEIN INTERACTION FOCUSED LIBRARY TARGETING BIG3-PHB2 INTERACTION. Takeru Chigira , Satoru Nagatoishi, Kouhei Tsumoto 2679-Pos Board B56 PEPTIDES DERIVED FROM CXCL8 BASED ON IN SILICO ANALYSIS INHIBIT CXCL8 INTERACTIONS WITH ITS RECEPTOR CXCR1. Chun-Chun Chang, Shinn-Jong Jiang, Je-Wen Liou, Yi Chung, Hao-Jen Hsu 2680-Pos Board B57 PROTEIN-PEPTIDE DOCKING WITH HIGH CONFORMATIONAL FLEXIBILITY USING CABS-DOCK WEB TOOL. Maksim Kouza , Maciej Blaszczyk, Mateusz Kurcinski, Lukasz Wieteska, Aleksander Debinski, Andrzej Kolinski, Sebastian Kmiecik 2681-Pos Board B58 INCREASED FLEXIBILITY OF LOCAL CONFORMATION IN THE N-TERMINAL DOMAIN OF MDMX ENHANCES LIGAND-BINDING AFFINITY. Lingyun Qin , Rong Chen, Huili Liu, Zhengding Su 2682-Pos Board B59 THE INFLUENCES OF DRUG-RESISTANT MUTATIONS OF EGFR TO THE INHIBITOR BINDING AFFINITY AND THE DRUG TARGET SELECTIVITY PRO- FILES.  Jiyong Park , Joseph J. McDonald, Russell C. Petter, Ken Houk 2683-Pos Board B60 THE IMPACT OF EXPERIMENTAL, PROTEIN STRUCTURE ON OUR ABILITY TO MODEL PROTEIN FUNCTION. Oleg Y. Borbulevych , Lance M. Westerhoff 2684-Pos Board B61 HEPARIN-SCLEROSTIN INTERACTIONS FROM SURFACE PLASMON RESO- NANCE AND MOLECULAR DYNAMICS SIMULATIONS.  J. Joel Janke , Fuming Zhang, Robert J. Linhardt, Angel E. Garcia 2685-Pos Board B62 MOLECULAR BASES BASIS OF ANTIBIOTIC TRANSLOCATION ACROSS OUTER MEMBRANE PORINS OF ENTEROBACTER AEROGENES.  Jiajun Wang , Muriel Masi, Harsha Bajaj, Mohamed Kreir, Mathias Winterhalter, Niels Fertig 2686-Pos Board B63 STUDY OF LIGAND BINDING SELECTIVITY OF HISTONE DEACETYLASES BY REPLICA-EXCHANGE UMBRELLA SAMPLING MOLECULAR DYNAM- ICS SIMULATIONS. Shuichiro Tsukamoto , Yoshitake Sakae, Yukihiro Itoh, Takayoshi Suzuki, Yuko Okamoto 2687-Pos Board B64 INTERNATIONAL TRAVEL AWARDEE PREDICTING LIGAND SELECTIVITY ACROSS BROMODOMAIN FAMI- LIES. Matteo Aldeghi , Alexander Heifetz, Michael J. Bodkin, Stefan Knapp, Philip C. Biggin 2688-Pos Board B65 A MOLECULAR DYNAMICS STUDY OF MICHAELIS COMPLEX FOR DESIGN- ING SELECTIVE TRANSITION STATE ANALOG INHIBITORS FOR CYSTEINE PROTEASE CALPAIN-2. Payal Chatterjee , Abdelaziz Alsamarah, David Kent, Li Qian, David Wych, Christine N. Pham, Alla Avetisyan, Steven Standley, Michel Baudry, Yun Luo

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