Biophysical Society 60th Annual Meeting

Voltage-gated K Channels and Mechanisms of Voltage Sensing and Gating III (Boards B343 - B347) 2966-Pos Board B343 TRYPTOPHAN 207 IS CRUCIAL TO THE UNIQUE PROPERTIES OF THE HU- MAN VOLTAGE GATED PROTON CHANNEL, HHV1. Vladimir V. Cherny, Deri Morgan, Boris Musset, Gustavo Chaves2, Susan M.E. Smith, Thomas E. DeCoursey 2967-Pos Board B344 HV1 PROTON CHANNEL RESTING-STATE VOLTAGE SENSOR MODEL STRUCTURES ARE REFINED BY EXPERIMENTAL MAPPING OF ZINC-CO- ORDINATING RESIDUES. Victor De-la-Rosa , Ashley L. Bennett, Ian Scott Ramsey 2968-Pos Board B345 KVAP GATING STATES PROBED BY ELECTRON SPIN-ECHO ENVELOPE MODULATION (ESEEM) SPECTROSCOPY. Dylan O. Burdette , Adrian Gross 2969-Pos Board B346 REGULATION OF HERG1B BY HERG1A N-TERMINAL REGIONS. Beth A. McNally , Matthew C. Trudeau 2970-Pos Board B347 MULTIPLE METAL BRIDGES AT THE INTRACELLULAR GATE OF A VOLTAGE ACTIVATED POTASSIUM CHANNEL PREVENT CLOSING. Angel A. de la Cruz Landrau , Miguel Holmgren Ligand-gated Channels III (Boards B348 - B363) 2971-Pos Board B348 MOLECULAR MODELING OF CHARGE SELECTIVITY IN PENTAMERIC LIGAND-GATED ION CHANNELS. Tyler J. Harpole , Claudio Grosman 2972-Pos Board B349 PATCH CLAMP FLUOROMETRY IN OUTSIDE-OUT PATCHES FOR LIGAND- GATED ION CHANNELS. Matthias Wulf , Stephan A. Pless 2973-Pos Board B350 THE ROLE OF A TRYPTOPHAN CLUSTER IN THE EXTRACELLUAR DOMAIN OF CYS-LOOP RECEPTORS. Nina Braun , Timothy Lynagh, Rilei Yu, Philip C. Biggin, Stephan A. Pless 2974-Pos Board B351 EXPRESSION AND PURIFICATION OF THE INTRACELLULAR DOMAIN OF A CATIONIC PENTAMERIC LIGAND-GATED ION CHANNEL. Katharine Jenkins , Akash Pandhare, Laura J. Delin, Michaela Jansen 2975-Pos Board B352 FUNCTIONAL AND BIOCHEMICAL CHARACTERIZATION OF ALVINELLA POMPEJANA CYS-LOOP RECEPTOR HOMOLOGUES. Eveline Wijckmans , Mieke Nys, Sarah Debaveye, Marijke Brams, Els Pardon, Daniel Bertrand, Jan Steyaert, Chris Ulens 2976-Pos Board B353 UNDERSTANDING NICOTINIC RECEPTOR ASSEMBLY IN THE ENDOPLAS- MIC RETICULUMWITH SINGLE MOLECULE FLUORESCENCE MICROSCO- PY. Chris Richards , Ashley Loe, Faruk Moonschi 2977-Pos Board B354 PROBING BINDING INTERACTIONS OF AGONISTS WITH THE α6β2 NICO- TINIC ACETYLCHOLINE RECEPTOR. Michael R. Post , Dennis A. Dougherty, Henry A. Lester

2978-Pos Board B355 EFFECTS OF MENTHOL ON α3β4* NICOTINIC RECEPTORS. Suparna Patowary , Elisha D.W. Mackey, Sheri L. McKinney, Purnima Deshpande, Brandon J. Henderson, Gabriel Biener, Valerica Raicu, Henry A. Lester 2979-Pos Board B356 SELECTIVITY OF SPIROIMINE PHYCOTOXINS TOWARD NICOTINIC ACETYL- CHOLINE RECEPTORS. Bogdan I. Iorga , Rómulo Aráoz, Evelyne Benoit, Jordi Molgó 2980-Pos Board B357 SIMULATIONS OF ENDPLATE ACHRS: AGONIST SITE β-SHEET AND M1 π-HELIX. Srirupa Chakraborty , Anthony Auerbach 2981-Pos Board B358 FUNDAMENTAL CONSTANTS FOR ACTIVATION OF HUMAN ENDPLATE RECEPTORS. Anthony Auerbach , Tapan K. Nayak 2982-Pos Board B359 EFFECTS OF QUASI-NATIVE LIPID COMPOSITION ON MEMBRANE DOMAIN FORMATION INDUCED BY NICOTINIC ACETYLCHOLINE RECEP- TORS. LiamM. Sharp , Reza Salari, Grace Brannigan 2983-Pos Board B360 INTERACTOME MAPS OF THE ACETYLCHOLINE RECEPTOR GATE RE- GION. Tapan K. Nayak , Anthony Auerbach 2984-Pos Board B361 THE β2(+)/α4(-) INTERFACES OF (α4β2)2α4 NICOTINIC RECEPTORS ALLO- STERICALLY CONTRIBUTE TO RECEPTOR FUNCTION. Simone Mazzaferro , Isabel Bermudez, Silvia Garcia Del Villar, Karina K. New 2985-Pos Board B362 BETWEEN THE SHEETS: INTER-SUBUNIT BACKBONE INTERACTIONS AT ACHR NEUROTRANSMITTER BINDING SITES. Shaweta Gupta , Srirupa Chakraborty, Anthony Auerbach 2986-Pos Board B363 INTERACTION OF THE POSITIVE ALLOSTERIC MODULATOR LY2087101 WITH α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR. Ze-Jun Wang, Farah Deba, Tiffany R. Trevino, Kara Ramos, Ayman K. Hamouda Ion Channel Regulatory Mechanisms (Boards B364 - B388) 2987-Pos Board B364 HIGH MEMBRANE PERMEABILITY FOR MELATONIN. Haijie Yu , Eamonn Dickson, Seung-Ryoung Jung, Duk-Su Koh, Bertil Hille 2988-Pos Board B365 LOCKING THE ASYMMETRIC OPEN CONFORMATION OF MG 2+ CHANNEL CORA WITH A SYNTHETIC ANTIBODY FRAGMENT. Bharat Reddy , Pawel Dominik, Olivier Dalmas, Tony Kossiakoff, Eduardo Perozo 2989-Pos Board B366 MITOGENIC ACTIVATION AND PROLIFERATION OF T LYMPHOCYTES IN TRPM7 KINASE-DEAD MUTANT MICE. Pavani Beesetty , Masayuki Matsu- shita, J. Ashot Kozak 2990-Pos Board B367 DYNAMIC INTERPLAY OF CALMODULIN AND FIBROBLAST GROWTH FAC- TOR HOMOLOGOUS FACTORS IN REGULATING NA CHANNELS. Manu B. Johny , Gordon F. Tomaselli, David T. Yue 2991-Pos Board B368 CPOW TRAVEL AWARDEE SECRETED HUMAN CLCA1 ACTIVATES CALCIUM-DEPENDENT CHLORIDE CURRENTS THROUGH DIRECT BINDING OF ITS VWA DOMAIN WITH AN EXTRACELLULAR LOOP OF TMEM16A/ANOCTAMIN 1. Monica Sala-Rabanal , Zeynep Yurtsever, Colin G. Nichols, Tom J. Brett

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