Biophysical Society 60th Annual Meeting

Platform Cell Mechanics, Mechanosensing, and Motility I 10:45 am - 12:45 pm, Room 502B Co-Chairs Melissa Knothe Tate, University of New South Wales, Australia Mohammad Mofrad, University of California, Berkeley 129-Plat 10:45 am MECHANO-SENSITIVE INTERACTION BETWEEN TALIN AND FULL-LENGTH VINCULIN.  Yinan Wang , Benjamin T. Goult, Mingxi Yao, Jie Yan 130-Plat 11:00 am DISSIPATION OF STRESS IN THE CYTOSKELETON VIA ALPHA-ACTININ DYNAMIC CROSSLINKING.  Hossein Khadivi Heris , Adele Khavari, Adam Hendricks, Allen Ehrlicher 131-Plat 11:15 am MECHANOTRANSDUCTION OF THE ENDOTHELIAL GLYCOCALYX MEDIATES NITRIC OXIDE PRODUCTION THROUGH ACTIVATION OF TRP CHANNELS.  Matthew Dragovich , Daniel Chester, X. Frank Zhang 132-Plat 11:30 am A LAMIN A CHIMERIC PROTEIN CONTAINING A FRET BASED STRESS SEN- SORS REPORTS SPATIO-TEMPORAL FORCES IN THE NUCLEAR LAMINA.  Thomas M. Suchyna , Fanji Meng, Frederick Sachs, Wilma Hofmann 133-Plat 11:45 am EDUCATION TRAVEL AWARDEE MOLECULAR MECHANISMS OF MECHANOTRANSDUCTION THROUGH LINC COMPLEXES.  Zeinab Jahed , Hengameh Shams, Mohammad Mofrad 134-Plat 12:00 pm CELL INVASION THROUGH STIFF CONSTRICTIONS CAUSES MUTATIONS WHILE DAMAGING THE NUCLEUS.  Jerome Irianto , Charlotte R. Pfeifer, Avathamsa Athirasala, Irena L. Ivanovska, Roger E. Greenberg, Dennis E. Discher 135-Plat 12:15 pm VISUALIZING DIRECT INTERACTIONS IN THE MECHANOBIOME.  Priyanka Kothari , Vasudha Srivastava, Irina Tchernyshyov, Jennifer Van Eyk, Douglas N. Robinson 136-Plat 12:30 pm MAPPING THE MECHANOME: NEW EXPERIMENTAL AND COMPUTA- TIONAL APPROACHES TO ELUCIDATE STEM CELL MECHANOADAPTATION AND LINEAGE COMMITMENT. Melissa L. Knothe Tate , Iman Jalilian, Min Jae Song, Sara McBride Platform TRP Channels 10:45 am - 12:45 pm, Room 515A Co-Chairs Avi Priel, The Hebrew University of Jerusalem, Israel Theodore Wensel, Baylor College of Medicine 137-Plat 10:45 am THE STOICHIOMETRY AND ACTIVATION MECHANISM OF TRPV1 BY VANIL- LOIDS.  Rakesh Kumar, Adina Hazan, Henry Matzner, Avi Priel 138-Plat 11:00 am ION-ION INTERACTION AT THE MULTI-ION TRPV1 PORE.  Bo Hyun Lee , Jie Zheng 139-Plat 11:15 am A COMBINED COARSE-GRAINED AND ALL-ATOMMOLECULAR SIMULA- TION OF THE TRPV1 CHANNEL. Wenjun Zheng

140-Plat 11:30 am N-HMME UPREGULATES LIPOLYTIC PROTEINS IN THE LIVER TO COUNTER NAFLD.  Padmamalini Baskaran , Ross Cook, Sara Cisneros, Steven McAllisted, Baskaran Thyagarajan 141-Plat 11:45 am STRUCTURE OF THE FULL-LENGTH TRPV2 CHANNEL BY CRYOEM.  Kevin Huynh 142-Plat 12:00 pm STRUCTURAL BASIS OF TRPV2 CHANNEL GATING INVESTIGATED WITH CRYO-EM.  Timothy L. Dosey , Zhao Wang, Fan Guizhen, Irina I. Serysheva, Wah Chiu, Theodore G. Wensel 143-Plat 12:15 pm STRUCTURE OF THE TRPA1 ION CHANNEL SUGGESTS REGULATORY MECHANISMS.  Candice E. Paulsen , Jean-Paul Armache, Yuan Gao, Yifan Cheng, David Julius 144-Plat 12:30 pm THE ROLE OF LIPID RAFTS IN THE LOCALIZATION AND FUNCTION OF THE CHEMOSENSORY TRPA1 CHANNEL.  Justyna B. Startek , Debapriya Ghosh, Yeranddy A. Alpizar, Alejandro López-Requena, Nele Van Ranst, Thomas Voets, Karel Talavera Platform Protein Assembly and Function 10:45 am - 12:45 pm, Room 515B Co-Chairs Jennifer Boatz, University of Pittsburgh Jochen Mueller, Ludwig Maximilian University of Munich, Germany 145-Plat 10:45 am STRUCTURAL STUDIES OF THE OLIGOMERIZATION PROCESS OF HUMAN CYSTATIN C VARIANTS.  Zuzanna Pietralik, Magdalena Murawska, Aneta Szymanska, Janet R. Kumita, Christopher M. Dobson, Maciej Kozak 146-Plat 11:00 am THE STRUCTURAL BASIS OF ENZYME REGULATION BY CTP SYNTHASE METABOLIC FILAMENTS.  Eric Lynch, Justin Kollman 147-Plat 11:15 am TUBULIN MONOMER-MONOMER ASSOCIATION IS LESS INFLUENCED BY THE SOLVENT THAN DIMER-DIMER ASSOCIATION: STRUCTURE AND FUNCTION OF TUBULIN INTERACTION INTERFACES.  Felipe Montecinos- Franjola , Peter Schuck, Dan L. Sackett 148-Plat 11:30 am STRUCTURAL STUDIES OF PLANT CESA SUPPORT EIGHTEEN CESAS IN THE PLANT CSC.  Venu G. Vandavasi , Daniel K. Putnam, Qiu Zhang, Loukas Pe- tridis, William T. Heller, B. Tracy Nixon, Candace H. Haigler, Udaya Kalluri, Leighton Coates, Paul Langan, Jeremy C. Smith, Jens Meiler, Hugh O’Neill 149-Plat 11:45 am STRUCTURAL INSIGHTS INTO TC TOXIN ACTION.  Stefan Raunser 150-Plat 12:00 pm AN INVESTIGATION OF THE ATOMIC STRUCTURE OF CATARACT-FORM- ING MUTANT GAMMA-D-CRYSTALLIN AGGREGATES FORMED UNDER DISTINCT ENVIRONMENTAL CONDITIONS.  Jennifer C. Boatz , Matthew J. Whitley, Cody L. Hoop, Xuemei Zeng, Nathan Yates, Angela M. Gronenborn, Patrick C A van der Wel 151-Plat 12:15 pm THE GIANT CYTOSKELETAL PROTEIN OBSCURIN ACTS AS A VARIABLE FORCE RESISTOR.  Nathan T. Wright , Tracy A. Caldwell, Logan C. Meyer

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