Biophysical Society 60th Annual Meeting

Platform Membrane Protein Structure and Folding I 4:00 pm - 6:00 pm, Room 501ABC Co-Chairs Vadim Cherezov, University of Southern California Syma Khalid, University of Southampton, United Kingdom 205-Plat 4:00 pm ARNT: STRUCTURE AND MECHANISM OF THE AMINOARABINOSE TRANSFERASE RESPONSIBLE FOR RESISTANCE TO POLYMYXIN-CLASS ANTIBIOTICS.  Vasileios I. Petrou , Carmen M. Herrera, Kathryn M. Schultz, Oliver B. Clarke, Jeremie Vendome, David Tomasek, Surajit Banerjee, Kanagalaghatta R. Rajashankar, Brian Kloss, Edda Kloppmann, Burkhard Rost, Candice S. Klug, M. Stephen Trent, Lawrence Shapiro, Filippo Mancia 206-Plat 4:15 pm STRUCTURAL STUDIES OF THE HUMAN KAPPA OPIOID RECEPTOR ACTIVE STATE CONFORMATIONS. Ming-Yue Lee , Nilkanth Patel, Vsevolod Katritch, Raymond C. Stevens, Vadim Cherezov 207-Plat 4:30 pm CRYSTAL STRUCTURE OF THE CALCIUM ATPASE SERCA IN COMPLEX TO A NOVEL ANTI-CANCER AGENT THAT TARGETS MULTIDRUG-RESISTANT LEUKEMIA.  John K. Lee , Joseph M. Autry, Razvan Cornea, Nicholas Bleeker, Denise Casemore, Chengguo Xing, David D. Thomas 208-Plat 4:45 pm CPOW TRAVEL AWARDEE ADVANCES IN IN SITU X-RAY CRYSTALLOGRAPHY OF MEMBRANE PROTEINS.  Jana Broecker , Viviane Klingel, Bryan T. Eger, Oliver P. Ernst 209-Plat 5:00 pm A MACHINE LEARNING APPROACH TO HETEROLOGOUS MEMBRANE PROTEIN OVEREXPRESSION​.  ShyamM. Saladi , Nauman Javed, Axel Müller, WilliamM. Clemons 210-Plat 5:15 pm LINKING THE OUTER MEMBRANE OF E.COLI TO THE CELL WALL VIA OMPA & BRAUN’S LIPOPROTEIN: TOWARDS A MOLECULAR MODEL OF A VIRTUAL BACTERIAL CELL ENVELOPE.  Syma Khalid , Maite Ortiz-Suarez, Peter J. Bond, Thomas Piggot 211-Plat 5:30 pm SYSTEMATIC EVALUATION OF THE CS-ROSETTA DE NOVO STRUCTURE PREDICTION METHOD FOR MEMBRANE PROTEINS.  Katrin Reichel , Olivier Fisette, Tatjana Braun, Gerhard Hummer, Oliver Lange, Lars Schäfer 212-Plat 5:45 pm INSIGHTS INTO HOWMUTATIONS THERMOSTABILIZE G-PROTEIN-COU- PLED RECEPTORS.  Nagarajan Vaidehi , Sangbae Lee, Supriyo Bhattacharya, Manbir Sandhu, Reinhard Grisshammer, Christopher G. Tate

195-Plat 5:30 pm STIRRING A LOW REYNOLDS NUMBER MARTINI.  Edward R. Lyman 196-Plat 5:45 pm VENI, VIDI, VORONOI: ATTACKING VIRUSES WITH SPHERICAL VORONOI DIAGRAMS.  Tyler Reddy , Ross Hemsley, Edd Edmondson, Nikolai Nowac- zyk, Joe Pitt-Francis, Mark S.P. Sansom Platform Intrinsically Disordered Proteins (IDP) and Aggregates I 4:00 pm - 6:00 pm, Room 515B Co-Chairs Claudiu Gradinaru, University of Toronto, Canada Ana Melo, University of Pennsylvania 197-Plat 4:00 pm CPOW TRAVEL AWARDEE DETERMINING A TOPOLOGICAL MODEL FOR TAU BOUND TO TUBULIN HETERODIMERS.  Ana M. Melo , Garrett Cobb, Juliana Coraor, Shana Elbaum-Garfinkle, Elizabeth Rhoades 198-Plat 4:15 pm A NEW APPROACH TO INFER SIZE AND SHAPE OF DISORDERED CONFOR- MATIONS OF PROTEINS FROM SM-FRET DATA.  Gregory-Neal Gomes, Jianhui Song, Hue-Sun Chan, Claudiu C. Gradinaru 199-Plat 4:30 pm FTIR STUDY REVEAL INTRINSICALLY DISORDERED NATURE OF HEAT SHOCK PROTEIN 90.  Aihua Xie , Maurie Balch, David Neto, Oliver Causey, Johnny Hendriks, Junpeng Deng, Robert Matts 200-Plat 4:45 pm PHYSICAL PRINCIPLES THAT GOVERN THE SEQUENCE-ENCODED PHASE BEHAVIOR OF INTRINSICALLY DISORDERED BLOCK-COPOLYMERIC PROTEINS.  Alex S. Holehouse , Tyler S. Harmon, Rohit V. Pappu 201-Plat 5:00 pm CYTOTOXICITY OF PRION PROTEIN-DERIVED CELL PENETRATING PEPTIDES IS INDEPENDENT OF AMYLOID FORMATION.  Vineeth Mukundan, Christy Maksoudian, Maria Vogel, Mazin Magzoub 202-Plat 5:15 pm INTRINSICALLY DISORDERED PROTEINS DRIVE MEMBRANE CURVATURE.  David J. Busch , Justin R. Houser, Carl C. Hayden, Michael B. Sherman, Eileen M. Lafer, Jeanne C. Stachowiak 203-Plat 5:30 pm KINETICS OF AMYLOID FIBRIL SELF-ASSEMBLY BY DIRECT OBSERVATION OF ELONGATION.  Laurence J. Young , Clemens F. Kaminski 204-Plat 5:45 pm FROM PHYSIOLOGICAL FLUIDS TO PATHOLOGICAL GELS: DISORDERED PROTEINS AT THE NEXUS OF LIQUID PHASE SEPARATION AND NEURODE- GENERATIVE DISEASE.  Shana Elbaum-Garfinkle, Nicole Taylor , Clifford P. Brangwynne

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