Biophysical Society 60th Annual Meeting

613-Pos Board B393 THE LOAD DEPENDENCE OF THE SIZE AND THE SPEED OF THE WORKING STROKE OF CARDIAC MYOSIN IN SITU. Marco Caremani, Francesca Pinza- uti, Massimo Reconditi, Gabriella Piazzesi Piazzesi, Vincenzo Lombardi, Ger J. Stienen , Marco Linari 614-Pos Board B394 EFFECT OF STIMULATION FREQUENCY MODULATION ON CROSS-BRIDGE CYCLING RATE OF EXPLANTED HUMAN MYOCARDIUMWITH NON-ISCH- EMIC AND ISCHEMIC CARDIOMYOPATHY.  Jae-Hoon Chung 615-Pos Board B395 ASSESSMENT OF CARDIAC EFFECTS OF PROTEIN KINASE A AND PROTEIN KINASE C INHIBITORS ON MYOFILAMENT-BASED CONTRACTILE ACTIVA- TION IN FAILING HUMAN MYOCARDIUM. Nancy S. Saad 616-Pos Board B396 THE BENEFITS OF VOLUNTALY EXERSICE ON CARDIAC FUNCTION IN DCM MODEL MICE. Masami Sugihara , Ryo Kakigi, Takashi Murayama, Takashi Sakurai, Takashi Miida, Sachio Morimoto, Nagomi Kurebayashi 617-Pos Board B397 DATP RESTORES THE CONTRACTILE FUNCTION OF CARDIAC MYOFIBRIL FROM ADULT DOGS WITH NATURALLY OCCURRING DILATED CARDIOMY- OPATHY. Yuanhua Cheng , Kaley A Hogarth, M Lynne O’Sullivan, Michael Regnier, W Glen Pyle 618-Pos Board B398 TIME-COURSE OF CARDIAC MYOFIBRILLAR CONTRACTILE PROPERTIES DURING THE PROGRESSION OF RAT HYPERTENSIVE HEART FAILURE.  Laurin M. Hanft , Craig A. Emter, Kerry S. McDonald 619-Pos Board B399 AMP KINASE MODULATES HEART RATE AND HEART RATE VARIABILITY THROUGH AUTONOMIC AND INTRINSIC MECHANISMS.  Jack M. Moen , Ismayil Ahmet, Arash Yavari, Michael G. Matt, Max G. Beyman, Christo- pher Ramirez, Houman Ashrafian, Edward G. Lakatta 620-Pos Board B400 UNIQUE LOCALIZATION OF PHOSPHOLAMBAN IN PERINUCLEAR MEM- BRANES OF CARDIOMYOCYTES FROM SEVERAL SPECIES. Yu-An Chiou, Yen-Ling Sung, Peng-Sheng Chen, Shien-Fong Lin, Zhenhui Chen 621-Pos Board B401 SPATIAL AND FUNCTIONAL INTERACTIONS BETWEEN SK CHANNELS AND L-TYPE CALCIUM CHANNELS IN CARDIOMYOCYTES. Xiao-Dong Zhang , Wei Chun Chen, Jeong-Han Lee, Zhong Jian, Gu Dai, Leighton Izu, Ye Chen-Izu, Nipavan Chiamvimonvat 622-Pos Board B402 ZACOPRIDE, A NOVEL IK1 ACTIVATOR, IS A POTENTIAL EFFECTIVE TREATMENT FOR TRIGGERED ARRHYTHMIA IN SUSCEPTIBLE HUMAN HEARTS. Mohammad T. Elnakish , , Benjamin D. Canan, Robert SD Higgins, Ahmet Kilic, Peter J. Mohler, Paul ML Janssen 623-Pos Board B403 COMPUTATIONAL STUDY OF HUMAN-AMYLIN INDUCED CALCIUM DYSREGULATION IN CARDIAC MYOCYTES CHARACTERISTIC OF PRE-DIABE- TES. Caitlin Scott, Florin Despa, Sanda Despa, Peter M. Kekenes-Huskey 624-Pos Board B404 SMALL OBSCURINS AT THE INTERCALATED DISC MEDIATE STRUCTURE, CELL SIZE, AND ADHESION. Maegen Ackermann , Brendan King, Nicole Perry, Michael Rudloff, Christopher Berndsen, Nathan Wright, Peter Hecker, Aikaterini Kontrogianni-Konstantopoulos 625-Pos Board B405 MODELING THE RESPONSE OF CARDIAC TROPONIN C TO CALCIUM ON THE THIN FILAMENT: EFFECTS OF DISEASE-RELATED AND POST-TRANS- LATIONAL MODIFICATIONS.  Jalal K. Siddiqui , Bin Liu, Shane D. Walton, Vikram K. Shettigar, Andrew J. O’Neil, Grace A. Davis, Peeyush Shrivastava, Jianchao Zhang, Brandon Biesiadecki, Jonathan P. Davis

600-Pos Board B380 HUMAN CONNEXIN 26 (CX26) N14K MUTANT ALTERS HEMICHANNEL CALCIUM AND VOLTAGE SENSITIVITY.  Juan M. Valdez Capuccino , William Lopez, Andrew L. Harris, Jorge E. Contreras 601-Pos Board B381 NITRIC OXIDE INCREASES ENDOTHELIAL CELL MEMBRANE PERMEABIL- ITY VIA S-NITROSYLATION-MEDIATED OPENING OF CX43 HEMICHAN- NELS. Mauricio A. Lillo , Jorge E. Contreras, Xavier F. Figueroa 602-Pos Board B382 A NOVEL E. COLI-BASED ASSAY FOR RAPID SCREENING OF HEMICHAN- NEL FUNCTION. Srinivasan Krishnan , D. Marien Cortés, Guillermo A. Altenberg, Luis G. Cuello 603-Pos Board B383 ENGINEERED CX40 VARIANTS SHOWED HETEROTYPIC COLOCALIZATION AND INCREASED GAP JUNCTIONAL COUPLING WITH CX43. Arjewan Jassim, Hiroshi Aoyama, Willy G. Ye, Honghong Chen, Donglin Bai 604-Pos Board B384 WATER DYNAMICS AND ION INTERACTION AT CHANNEL ENTRANCE OF AQUAPORIN 1. Eiji Yamamoto , Takuma Akimoto, Masato Yasui, Kenji Board B385 EFFECT OF LIPID LAYER ON THE WATER PERMEABILITY OF AQUAPORIN: A MOLECULAR DYNAMICS STUDY. Sangjae Seo , Youngjin Kim, Hyunki Kim, Moon Ki Kim 606-Pos Board B386 HIGHLY PERMEABLE ARTIFICIAL WATER CHANNELS THAT SELF-ASSEMBLE INTO TWO-DIMENSIONAL ARRAYS. Karl Decker 607-Pos Board B387 AN INSECT PROTON CHANNEL. Gustavo Chaves, Christian Derst, Arne Franzen, Ryuichiro Machida, Yuta Mashimo, Boris Musset 608-Pos Board B388 NOVEL PLAYERS IN THE CONTROL OF MITOCHONDRIAL ION HOMEOSTA- SIS. Angela Paggio , Vanessa Checchetto, Ildikò Szabò, Rosario Rizzuto, Diego De Stefani 609-Pos Board B389 MEMBRANE-SPANNING DNA ION CHANNELS: CONDUCTANCE MECHA- NISM, ELECTRO-OSMOTIC TRANSPORT AND MECHANICAL GATING.  Jejoong Yoo, Chen-Yu Li , Aleksei Aksimentiev 610-Pos Board B390 OLIGOMERIZATION STATES OF LRRC8A AND LRRC8B, ESSENTIAL COMPO- NENTS OF THE VOLUME-REGULATED ANION CHANNEL VRAC. Gunther Schmalzing , Silvia Detro-Dassen, Christoph Fahlke, Fritz Markwardt Cardiac Muscle Regulation (Boards B391 - B413) 611-Pos Board B391 MECHANICAL SIGNALING COORDINATES THE EMBRYONIC HEART- BEAT. Kevin K. Chiou , Jason W. Rocks, Sangkyun Cho, Koen E. Merkus, Patrick Robison, Manorama Tewari, Kenneth Vogel, Stephanie F. Majkut, Benjamin L. Prosser, Dennis E. Discher, Andrea J. Liu 612-Pos Board B392 SIMULTANEOUS MEASUREMENT OF FORCE AND LATTICE SPACING IN SKINNED CARDIAC FIBERS. David Gonzalez-Martinez, Maicon Landim- Vieira, Olga A. Antipova, Omar Awan , P. Bryant Chase, Thomas Irving, Jose R. Pinto Yasuoka 605-Pos

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