Biophysical Society 60th Annual Meeting

898-Plat 10:00 am FUNCTIONAL CHARACTERIZATION OF CALCIUM-ACTIVATED PHOSPHO- LIPID SCRAMBLASE ACTIVITY OF NHTMEM16.  Tao Jiang , Sundar Thangapandian, Emad Tajkhorshid Platform Protein Stability, Folding, and Chaperones I 8:15 am - 10:15 am, Room 515B Co-Chairs Susan Marqusee, University of California, Berkeley Hugo Sanabria, Clemson University 899-Plat 8:15 am MECHANICAL UNFOLDING OF E. COLI RNASE H REVEALS AN INTERME- DIATE WITH A FORCE-INDUCED SHIFT IN THE RATE-LIMITING BARRIER.  Diane M. Wiener , Jesse W. Dill, Susan Marqusee 900-Plat 8:30 am IN-CELL PROTEIN FOLDING - PAPS SYNTHASES.  Oliver Brylski, David Gnutt, Simon Ebbinghaus 901-Plat 8:45 am PROVING THE ROLE OF ENTROPIC ELASTICITY IN PROTEIN FOLDING.  Jessica Valle-Orero , Edward C. Eckels, Ionel Popa, Jaime Andres Rivas-Pardo, Julio M. Fernandez 902-Plat 9:00 am SUB-MILLISECOND UNFOLDING KINETIC SPECTRA REVEALS INTERMEDI- ATE TRANSITIONS.  Hugo Sanabria , Katherina Hemmen, Dmitro Rodnin, Daniel Rohrbeck, Soheila Rezai Adariani, Ralf Kühnemuth, Claus A. M. Seidel 903-Plat 9:15 am STUDYING THE FUNCTION OF BAP IN THE NUCLEOTIDE CYCLE OF BIP BY SPFRET USING MFD-PIE.  Daniela Wengler , Mathias Rosam, Jelle Hendrix, Johannes Buchner, Don C. Lamb 904-Plat 9:30 am THE EFFECT OF LOOP INSERTIONS ON THE FOLDING OF TANDEM-REPEAT PROTEINS.  Albert Perez-Riba , Ewan R. Main, Laura S. Itzhaki 905-Plat 9:45 am LINKING MECHANOCHEMISTRY TO PROTEIN FOLDING AT THE SINGLE BOND LEVEL.  Amy EM Beedle , Sergi Garcia-Manyes 906-Plat 10:00 am FOLDING DYNAMICS OF B1 DOMAIN OF PROTEIN G USING SINGLE MOL- ECULE FORCE SPECTROSCOPY.  Dena Izadi Platform Excitation-Contraction Coupling 8:15 am - 10:15 am, Room 501ABC Co-Chairs Bradley Launikonis, University of Queensland, Australia Isabelle Marty, Grenoble Institut des Neurosciences, France 907-Plat 8:15 am THE MICROTUBULE-ASSOCIATED PROTEIN CLIMP-63 IS A NEWMEMBER OF THE CALCIUM RELEASE COMPLEX.  Alexis Osseni, Muriel Sebastien, Julien Fauré, Anne Fourest-Lieuvin, Isabelle Marty 908-Plat 8:30 am STRUCTURAL INSIGHTS INTO RYANODINE RECEPTOR-FKBP12 INTERAC- TIONS IN WILD-TYPE AND MUTATED STATES.  Zhiguang Yuchi , Siobhan MWong King Yuen, Kelvin Lau, Ainsley Underhill, Razvan Cornea, James Fessenden, Filip Van Petegem

887-Plat 9:15 am A TRIO OF CATIONS IN GRAMICIDIN A CHANNEL: IMPORTANCE OF QUANTUM EFFECTS TO DESCRIBE ION SELECTIVITY OF K + AND NA + , AND PROTON TRANSFER.  Van Ngo , Sergei Yu Noskov 888-Plat 9:30 am REDUCING IAPP AGGREGATION WITH MITOCHONDRIAL HUMANIN PEPTIDES; RESULTS FROM SIMULATIONS AND EXPERIMENTS.  Zachary A. Levine , Alan Okada, Kazuki Teranishi, Ralf Langen, Joan-Emma Shea 889-Plat 9:45 am RATIONAL DEVELOPMENT OF A NEW TYPE OF HBV CAPSID INHIBITORS BY A COMBINATION OF MICROSECOND-SCALE MOLECULAR DYNAMICS AND DOCKING. Maksym Korablyov, Anna Pavlova , James Gumbart 890-Plat 10:00 am HOLLIDAY JUNCTION THERMODYNAMICS AND STRUCTURE: COMPARI- SONS OF COARSE-GRAINED SIMULATIONS AND EXPERIMENTS.  Francis W. Starr , Wujie Wang, Laura M. Nocka, Brianne Z. Wiemann, Daniel M. Hinckley, Ishita Mukerji Platform Membrane Pumps, Transporters, and Exchangers 8:15 am - 10:15 am, Room 515A Co-Chairs Merritt Maduke, Stanford University Pernilla Wittung-Stafshede, Umeå Univeristy, Sweden 891-Plat 8:15 am AN OUTWARD-FACING OPEN CONFORMATIONAL STATE IN A CLC TRANS- PORTER.  Sherwin J. Abraham, Tanmay Chavan, Ricky C. Cheng, Cristina Fenollar-Ferrer, Wei Han, Shahidul M. Islam, Tao Jiang, Chandra M. Khantwal, Irimpan I. Mathews, Richard A. Stein, Benoit Roux, Lucy R. Forrest, Hassane S. Mchaourab, Emad Tajkhorshid, Merritt Maduke 892-Plat 8:30 am TRANSPORT MECHANISM OF THE EIIC GLUCOSE SUPERFAMILY OF TRANSPORTERS.  Zhenning Ren , Jason G. McCoy, Vitali Stanevich, Jumin Lee, Sharmistha Mitra, Elena J. Levin, Sebastien Poget, Matthias Quick, Wonpil Im, Ming Zhou 893-Plat 8:45 am DIRECT VISUALIZATION OF GLUTAMATE TRANSPORTER TRANSPORT CYCLE.  Yi Ruan, Atsushi Miyagi, Xiaoyu Wang, Mohamed Chami, Henning Stahlberg, Olga Boudker, Simon Scheuring 894-Plat 9:00 am RESOLVING ACTIVE ION TRANSPORT AT THE SINGLE MOLECULE LEVEL FOR THE FIRST TIME.  Salome Veshaguri , Sune M. Christensen, Gerdi C. Kemmer, Mads P. Møller, Garima Ghale, Christina Lohr, Andreas L. Christensen, Bo H. Justesen, Ida L. Jørgensen, Jürgen Schiller, Nikos S. Hatzakis, Michael Grabe, Thomas Gunther Pomorski, Dimitrios Stamou 895-Plat 9:15 am PROTEIN INTERACTIONS THAT ENABLE SAFE AND EFFICIENT COPPER ION TRANSPORT IN THE HUMAN CYTOPLASM.  Pernilla Wittung-Stafshede 896-Plat 9:30 am INTERNATIONAL TRAVEL AWARDEE DISSECTING THE CATALYTIC CYCLE OF THE SEROTONIN TRANSPORTER.  Peter S. Hasenhuetl , Michael Freissmuth, Harald H. Sitte, Klaus Schicker, Yang Li, Walter Sandtner 897-Plat 9:45 am TRANSLOCASE ACTIVITY AND ASYMMETRIC MODEL MEMBRANES PROBED BY NEUTRON SCATTERING.  Allison M. Whited , Frederick A. Heberle, Robert F. Standaert, Jonathan David Nickels, Xiaolin Cheng, John Katsaras, Alexander Johs

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