Biophysical Society 60th Annual Meeting

1013-Plat 5:15 pm IN SILICO STUDY ON THE LIGAND-BINDING AND ACTIVATION MECHA- NISMS OF THE HUMAN DOPAMINE D3 RECEPTOR. Wei-Hsiang Weng , Hao-Jen Hsu 1014-Plat 5:30 pm MIMICKING PROTEIN FUNCTIONS WITH ENTROPICALLY CONSTRAINED PEPTIDES.  Blake Farrow , Andrew G. Wang, David N. Bunck, James R. Heath 1015-Plat 5:45 pm LIGAND RESIDENCE TIMES AND EXIT PATHWAYS OBTAINED IN SILICO WITHOUT BIASING FORCES.  Alex Dickson Platform

1002-Plat 4:30 pm MECHANISM OF AMPA RECEPTOR GATING RE-SHAPED BY AUXILIARY PROTEINS.  George B. Dawe , Derek Bowie 1003-Plat 4:45 pm SENSING ALLOSTERIC MODULATOR BINDING TO AMPA RECEPTORS AT THE GLUTAMATE-BINDING SITE.  Christopher P. Ptak , Ahmed H. Ahmed, Robert E. Oswald 1004-Plat 5:00 pm ACID SENSING ION CHANNELS ARE UNIQUELY TUNED TO FOLLOW HIGH FREQUENCY ‘SYNAPTIC’ STIMULI.  David M. MacLean , Vasanthi 5:15 pm HUMAN α1 GLYCINE RECEPTOR ALLOSTERY AS IDENTIFIED BY STATE- DEPENDENT CROSSLINKING STUDIES. Michael Cascio , Rathna J. Veeramachaneni, Jeffry Madura 1006-Plat 5:30 pm CRYSTAL STRUCTURE OF HUMAN GLYCINE RECEPTOR-α3 BOUND TO ANTAGONIST STRYCHNINE.  Xin Huang 1007-Plat 5:45 pm MOLECULAR DETERMINANTS OF PARTIAL AGONIST AFFINITY IN ADULT NEUROMUSCULAR ACETYLCHOLINE RECEPTORS.  Iva Bruhova , Anthony Auerbach Platform Protein-Small Molecule Interactions 4:00 pm - 6:00 pm, Room 501ABC Co-Chairs Alex Dickson, Michigan State University Giulia Palermo, École Polytechnique Fédérale de Lausanne, Switzerland 1008-Plat 4:00 pm 2-DEOXY-ATP ENHANCES MULTIPLE KINETIC PARAMETERS TO IMPROVE CARDIAC FUNCTION.  Ivan B. Tomasic , Marcus Henze, Ferdinand Evangelista, Anu R. Anto, Hector Rodriguez, Sadie R. Bartholomew 1009-Plat 4:15 pm EXAMINATION OF CLPB QUATERNARY STRUCTURE AND LINKAGE TO NUCLEOTIDE BINDING.  JiaBei Lin , Aaron L. Lucius 1010-Plat 4:30 pm THUMB SITE 2 INHIBITORS OF HEPATITIS C VIRAL RNA-DEPENDENT RNA POLYMERASE ALLOSTERICALLY BLOCK THE TRANSITION FROM INITIATION TO ELONGATION.  Jiawen Li , Daniel Deredge, Patrick L. Wintrode, Kenneth A. Johnson 1011-Plat 4:45 pm MOLECULAR SIMULATIONS INTEGRATED WITH EXPERIMENTS UNRAVEL THE KEY FACTORS OF LIPID SELECTION IN FATTY ACID AMIDE HYDROLASE AND SUGGEST A GENERAL MECHANISM OF LIPID-PROCESSING IN THE PARENT ENZYMES.  Giulia Palermo , Inga Bauer, Pablo Campomanes, Andrea Cavalli, Andrea Armirotti, Stefania Girotto, Marco De Vivo, Ursula Rothlisberger 1012-Plat 5:00 pm CURCUMIN-LIKE COMPOUNDS DESIGNED TO MODIFY AMYLOID BETA PEPTIDE AGGREGATION PATTERN. Maria Grazia Ortore , Antonella Bat- tisti, Ranieri Bizzarri, Donatella Bulone, Claudio Ferrero, Francesco Ghetti, Valentina Giacalone, Antonino Lauria, Maria Rosalia Mangione, Antonella Marino Gammazza, Caterina Ricci, Antonella Sgarbossa, Francesco Spinozzi, Silvia Vilasi, Antonio Palumbo Piccionello Jayaraman 1005-Plat

M O N D A Y

Protein-Lipid Interactions I 4:00 pm - 6:00 pm, Room 511ABC

Co-Chairs Oliver Soubias, NIH Stephanie Tristram-Nagle, Carnegie Mellon University 1016-Plat 4:00 pm

PENETRATION OF HIV-1 TAT47-57 INTO PC/PE BILAYERS ASSESSED BY MD SIMULATION AND X-RAY SCATTERING.  Chris Neale, Kun Huang, Angel E. Garcia, Stephanie Tristram-Nagle 1017-Plat 4:15 pm INVESTIGATING THE INTERACTIONS OF PERIPHERAL MEMBRANE PRO- TEINS WITH MODEL MEMBRANES USING HIGH THROUGHPUT MOLECU- LAR DYNAMICS SIMULATIONS.  Antreas C. Kalli , Eiji Yamamoto, Fiona B. Naughton, Mark S.P. Sansom 1018-Plat 4:30 pm ELUCIDATING THE MECHANISM FOR STEROL REGULATION OF CHLORIDE INTRACELLULAR ION CHANNEL PROTEIN INTERACTIONS WITH LIPID MEMBRANES.  Khondker R. Hossain , Heba Al Khamici, Stephen A. Holt, Stella M. Valenzuela 1019-Plat 4:45 pm TRANSIENT EFFECT OF CALCIUM INFLUX ON PIP2 CLUSTERS IN THE IN- NER PLASMA MEMBRANE LEAFLET OF INTACT CELLS. Weixiang Jin , Arnd Pralle 1020-Plat 5:00 pm ELUCIDATING GPCR FUNCTIONAL DEPENDENCE ON PLASMA MEMBRANE COMPOSITION USING GIANT UNILAMELLAR PROTEIN-VESICLES. Mary Gertrude L. Gutierrez , Kylee Mansfield, Noah Malmstadt 1021-Plat 5:15 pm CONTROLLING GPCR RHODOPSIN FUNCTION BY SMALL, PHYSIOLOGI- CALLY RELEVANT CHANGES IN BILAYER HYDROPHOBIC THICKNESS.  Olivier Soubias , Alexander J. Sodt, Walter E. Teague, Kirk G. Hines, Klaus Gawrisch 1022-Plat 5:30 pm CHARACTERIZATION OF CEACAM1 AND LIPID RAFT NANOCLUSTERING, ASSOCIATION AND STRUCTURE BY DSTORM AND HOMO-FRET IMAGING.  Amine Driouchi , Maximilano Giuliani, Scott Gray-Owen, Christopher M. Yip 1023-Plat 5:45 pm STRUCTURAL DETERMINANTS OF RAFT PARTITIONING FOR SINGLE-PASS TRANSMEMBRANE PROTEINS.  Joseph H. Lorent , Barbara B. Diaz-Rohrer, Kandice R. Levental, Ilya Levental

64