Biophysical Society 61st Annual Meeting | Program Guide

1721-Pos Board B41 THE ROLE OF SOLVENT EFFECT ON THE LIGAND BINDING PROPERTIES OF THE THERMOSTABLE VARIANTS OF AMINOGLYCOSIDE NUCLEOTIDYL- TRANSFERASE 4`(ANT4). Seda Kocaman 1722-Pos Board B42 DEVELOPMENT OF AN IN VITRO FRET BASED INHIBITORY ASSAY FOR THE COILED-COILED INTERACTION BETWEEN MBD2CC AND P66ACR1. Victor C. Ekehchiadi 1723-Pos Board B43 THE BINDING OF METHYLENE BLUE TO PLASMODIUM FALCIPARUM GLU- TATHIONE REDUCTASE.  Judith H. Prieto 1724-Pos Board B44 LIGAND-ADOPTING MECHANISM OF THE P53-BINDING POCKET OF THE ONCOPROTEIN MDMX. Zheng Su , Lingyun Qin, Rong Chen, Fei Yang, Jingjing Zhou, Huili Liu 1725-Pos Board B45 BIOCHEMICAL AND BIOPHYSICAL CHARACTERIZATION OF A SMALL MOL- ECULE INTERACTION WITH THE RAS-RELATED PROTEIN CDC42. Djamali Muhoza, Alix Montoya-Beltrand, Paul D. Adams 1726-Pos Board B46 International Travel Awardee SHARK-DERIVED SINGLE DOMAIN ANTIBODIES TARGETING APOLIPOPRO- TEIN E. Shane E. Gordon , Michael Foley, Matthew A. Perugini 1727-Pos Board B47 MOLECULAR DYNAMICS AND DOCKING STUDIES ON NEUROTENSIN RE- CEPTOR. Rejwan Ali , Yasmeen Beasley, Tetyana Skazko, Mostafa Sadoqi, Mihaly Mezei Protein Dynamics and Allostery III (Boards B48–B63) 1728-Pos Board B48 A WEB-BASED INTERFACE FOR THE IDENTIFICATION OF ALLOSTERIC LIGAND BINDING SITES. Nabina Paudyal , Alemayehu A. Gorfe 1729-Pos Board B49 DEFINING AND EXPLORING ALLOSTERIC MUTATIONS.  Igor N. Berezovsky 1730-Pos Board B50 TRANSCRIPTIONAL REGULATION BY LOCKING AND UNLOCKING THE INTRINSIC DISORDER IN NFΚB. Wei Chen , Clarisse G. Ricci, J. AndrewMc- Cammon, Elizabeth A. Komives 1731-Pos Board B51 CONSTRUING THE DYNAMIC COMPLEXITY AT A PLAUSIBLE IKK2-NEMO INTERFACE.  Jamie M. Schiffer , Thuy Tien Nguyen, Ozlem Demir, Garret Chan, Rommie E. Amaro, Gourisankar Ghosh 1732-Pos Board B52 WHAT MAKES ENZYMES WORK? EXPLORING PROTEIN DYNAMICS IN P-T-X . Qi Huang, Jocelyn M. Rodgers, Russell J. Hemley, Toshiko Ichiye 1733-Pos Board B53 EXTREME BIOPHYSICS: ENZYMES UNDER PRESSURE. Qi Huang , Jocelyn M. Rodgers, Russell J. Hemley, Toshiko Ichiye 1734-Pos Board B54 IMPROVED RELAXATION MODE ANALYSIS OF A HEN EGG-WHITE LYSO- ZYME PROTEIN. Naoyuki Karasawa , Ayori Mitsutake, Hiroshi Takano 1735-Pos Board B55 IMPORTANCE OF PROTEIN VIBRATION DIRECTIONALITY ON FUNC- TION. Katherine A. Niessen , Mengyang Xu, Yanting Deng, Edward H. Snell, Andrea G. Markelz

1707-Pos Board B27 THE THERMODYNAMICS OF DIVALENT METALS BINDING TO TAURINE/Α- KETOGLUTARATE-DEPENDENT OXYGENASE (TAUD). Mingjie Li 1708-Pos Board B28 DISCRIMINATING RESIDUE SUBSTITUTIONS BETWEEN TWO, SINGLE PRO- TEINS WITH A SUB-NANOPORE. Zhuxin Dong 1709-Pos Board B29 EFFECTIVE ON-DEMAND MINING OF STRUCTURAL DATABASES. Lukas Pravda , David Sehnal, Radka Svobodova Varekova, Jaroslav Koca 1710-Pos Board B30 INTERCONNECTION BETWEEN PARALLEL ASSEMBLY PATHWAYS IN LARGE RIBOSOME SUBUNIT BIOGENESIS. Riley C. Gentry , Eda Koculi Protein-Small Molecule Interactions I (Boards B31–B47) 1711-Pos Board B31 KINETICS AND PATHWAYS OF EXTREMELY LONG LIGAND RELEASE EVENTS REVEALED BY WEXPLORE AND CONFORMATION SPACE NETWORKS. Sam- uel D. Lotz, Alex Dickson 1712-Pos Board B32 MACHINE LEARNING GUIDED LIGAND-PROTEIN SIMULATION APPROACH ELUCIDATES THE BINDING MECHANISM OF ABSCISIC ACID. Saurabh Shukla , Moeen Meigooni, Chuankai Zhao, Diwakar Shukla 1713-Pos Board B33 HYDRATION EFFECTS ON BINDING EQUILIBRIA: ROLE OF DESOLVATION ENERGY. Daryl K. Eggers 1714-Pos Board B34 A STRUCTURE BASED FRAMEWORK TO IDENTIFY NOVEL TARGETS OF FDA APPROVED KINASE INHIBITORS. Hammad Naveed 1715-Pos Board B35 A SYNTHETIC PEPTIDE FROM THE N-TERMINAL OF HEXOKINASE I PRE- VENTS THE INTERACTION BETWEEN VDAC1 AND SOD1 G93A MUTANT RECOVERING THE VIABILITY OF AN ALS CELL MODEL. Andrea Magri, Ramona Belfiore, Loredana Leggio, Francesca Guarino, Angela Messina 1716-Pos Board B36 MULTI-CONFORMER HIERARCHICAL VIRTUAL SCREENING WORKFLOW TO IDENTIFY POTENTIAL K-RAS INHIBITORS. Amit K. Gupta , Priyanka Prakash, John A. Putkey, Alemayehu A. Gorfe 1717-Pos Board B37 DATABASE OF CA PROTEIN-LIGAND BINDING GIBBS ENERGIES, EN- THALPIES, ENTROPIES, VOLUMES, AND CRYSTAL STRUCTURES. Vaida Linkuvienė , Asta Zubrienė, Vaida Paketurytė, Alexey Smirnov, Vytautas Petrauskas, Daumantas Matulis 1718-Pos Board B38 COMPARISON OF THE RGD- AND AGDV-CONTAINING PEPTIDE INTERAC- TIONS WITH THE PLATELET INTEGRIN ALPHAIIBBETA3. Rustem I. Litvinov , Olga Kononova, Dmitry S. Blokhin, Vladimir V. Klochkov, Valeri Barsegov, Joel S. Bennett, John W. Weisel 1719-Pos Board B39 BRUSHED POLYETHYLENE GLYCOL AND PHOSPHORYLCHOLINE AS PROM- ISING GRAFTING AGENTS AGAINST PROTEIN BINDING. Bo Wang , Thomas Blin, Aleksandr Käkinen, Xinwei Ge, Emily H. Pilkington, John F. Quinn, Michael R. Whittaker, Thomas P. Davis, Pu Chun Ke, Feng Ding 1720-Pos Board B40 INSIGHTS INTO A LOW PROMISCUOUS AMINOGLYCOSIDE MODIFYING ENZYME, AMINOGLYCOSIDE N3 ACETYLTRANSFERASE-VIA. Fnu Prashasti

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