Biophysical Society 61st Annual Meeting | Program Guide

2043-Pos Board B363 IDENTIFICATION OF ACTIVATING AND INHIBITING GATING MODIFIER TOX- INS THAT TARGET THE S3-S4 LOOP OF THE HUMAN PROTON CHANNEL, HHV1. Ruiming Zhao , Kelleigh Kennedy, Qufei Li, Eduardo Perozo, Steve A. N. Goldstein 2044-Pos Board B364 HCN3 CHANNEL EXPRESSION IN HUMAN LEUKOCYTES. Chiara Piantoni , Angelica Gualdoni, Claudia Bazzini, Raffaella Milanesi, Miryam Adelfio, Annalisa Bucchi, Andrea Barbuti, Matteo Pecchiari, Mirko Baruscotti, Dario DiFrancesco 2045-Pos Board B365 SILICA NANOPARTICLES INDUCE CALCIUM-PERMEABLE PORES IN PLASMA MEMBRANES. Alicia Sanchez , Kateryna Demydenko, Peter Hoet, Karel Talavera 2046-Pos Board B366 HOW TO GET LARGE DRUGS THROUGH SMALL PORES? EXPLOITING THE PORINS PATHWAY IN PSEUDOMONAS AERUGINOSA. Susruta Samanta, Tommaso D’Agostino, Ishan Ghai, Monisha Pathania, Silvia Acosta Gutier- rez, Mariano Andrea Scorciapino, Igor Bodrenko, Richard Wagner, Bert van den Berg, Mathias Winterhalter, Matteo Ceccarelli 2047-Pos Board B367 MOLECULAR TRANSPORT THROUGH LARGE DIAMETER DNA ORIGAMI CHANNELS. Swati Krishnan , Friedrich Simmel 2048-Pos Board B368 FINGERPRINTING AND DIFFERENTIATION OF SMALL PROTEINS WITH A LARGE CHANNEL OF BACTERIOPHAGE PHI29 DNA PACKAGING MO- TOR. Zhouxiang Ji , Shaoying Wang, Zhengyi Zhao, Zhi Zhou, Farzin Haque, Peixuan Guo 2049-Pos Board B369 PERTURBATION OF BILAYER SURFACE TENSION DIFFERENTIALLY MODU- LATES MECHANOSENSITIVE ION CHANNELS. Navid Bavi , Charles D. Cox, Omid Bavi, Boris Martinac 2050-Pos Board B370 NOVEL PROPERTIES OF LRRC8-MEDIATED VRAC CURRENTS. Antonella Gradogna, Héctor Gaitán-Peñas, Lara Laparra-Cuervo, Carles Solsona, Víctor Fernández-Dueñas, Alejandro Barrallo-Gimeno, Francisco Ciruela, Melike Lakadamyali, Raúl Estévez, Michael Pusch 2051-Pos Board B371 TRANSPORT OF SMALL AMINO ACIDS BY THE OUTER MEMBRANE PRO- TEIN OPRG OF PSEUDOMONAS AERUGINOSA . Patrick Seelheim , Raghav- endar Reddy Sanganna Gari, Iga Kucharska, Lukas K. Tamm 2052-Pos Board B372 FILTERING WITH THE ELECTRIC FIELD: A STORY ON PROTEIN CHANNELS ELECTROSTATICS. Silvia Acosta-Gutierrez , Giuliano Malloci, Igor Bodren- ko, Mariano Andrea Scorciapino, Matteo Ceccarelli 2053-Pos Board B373 HYDROPHOBIC GATING AND FUNCTIONAL ANNOTATION OF ION CHAN- NEL STRUCTURES BY MOLECULAR DYNAMICS SIMULATIONS. Gianni Klesse , Jemma Trick, Sivapalan Chelvaniththilan, Prafulla Aryal, Jayne Wallace, Stephen Tucker, Mark S.P. Sansom 2054-Pos Board B374 EVOLUTIONARY ANALYSIS DISCRIMINATES BETWEEN ALTERNATIVE ASIC STRUCTURES. Marina Kasimova, Timothy Lynagh, Daniele Granata, Stephan Pless, Vincenzo Carnevale

2031-Pos Board B351 RATIONAL DESIGN OF KCA2 CHANNEL ACTIVATORS. Heesung Shim , Bran- don Brown, Hai M. Nguyen, Vladimir Yarov-Yarovoy, Heike Wulff 2032-Pos Board B352 INVESTIGATION OF THE ION CHANNELS TMEM16A AND TRPC5 AND THEIR MODULATION BY INTRACELLULAR CALCIUM. Nina Brinkwirth, Søren Friis, Tom Goetze, Markus Rapedius, James Costantin , Andrea Brüggemann, Michael George, Niels Fertig 2033-Pos Board B353 STRUCTURAL DYNAMICS OF THE MSCL C-TERMINAL DOMAIN. Adam D. Martinac , Navid Bavi, Marien D. Cortes, Omid Bavi, Takeshi Nomura, Boris Martinac, Eduardo Perozo 2034-Pos Board B354 EXPRESSION AND CHARACTERIZATION OF WILDTYPE AND MUTANT FORMS OF HUMAN CONNEXIN31 USING XENOPUS OOCYTES. Rasheed Bailey , Husain Bneed, Dawn Fernandez, Shelby Rarick, Shahd Kadhim, Martha Skerrett 2035-Pos Board B355 MODULATION OF GABA(A) RECEPTORS BY GENERAL ANESTHETICS : A COMBINATORIC MODEL PREDICTS TWENTY YEARS OF CONCENTRATION- RESPONSE DATA (WITH A FEW INTERESTING EXCEPTIONS).  Grace Brannigan 2036-Pos Board B356 SUBTYPE SELECTIVITY OF TETS ON GABA-A RECEPTORS. Brandon Pressly , Hai M. Nguyen, Heike Wulff 2037-Pos Board B357 ANALYSIS OF PARTIAL AND COMPLETE BLOCK OF AMANTADINE AND RIMANTADINE IN INFLUENZA A M2 S31N BY ELECTROPHYSIOLOGY AND CURVE FITTING METHODS. Kelly L. McGuire , David D. Busath Other Channels I (Boards B358–B374) 2038-Pos Board B358 VOLTAGE- AND CURRENT CLAMP ON INDUCED PLURIPOTENT CARDIO- MYOCYTES WITH AUTOMATED PATCH CLAMP. Mads PG Korsgaard 2039-Pos Board B359 BIOPHYSICAL INSIGHT INTO THE SUBSTRATE PERMEATION THROUGH THE MAJOR OUTER MEMBRANE CHANNELS OF ACINETOBACTER BAU- MANNII . Satya Prathyusha Bhamidimarri , Michael Zahn, Jigneshkumar Dahyabhai Prajapati, Ulrich Kleinekathoefer, Bert van den Berg, Mathias Winterhalter 2040-Pos Board B360 THREE-STEP GATING TRIGGERED BY CONFORMATIONAL CHANGES OF THE MOTOR CHANNEL COMMON TO VIRAL DNA PACKAGING MOTOR OF T3, T4, SPP1, AND PHI29. Zhouxiang Ji , Shaoying Wang, Farzin Haque, Peixuan Guo 2041-Pos Board B361 PROBING THE ION PERMEABILITY OF THE BACTERIAL TRANSLOCON WITH A LOCKED TRANSLOCATION INTERMEDIATE AT THE SINGLE MOLECULE LEVEL. Denis G. Knyazev , Roland Kuttner, Mirjam Zimmermann, Christine Siligan, Peter Pohl 2042-Pos Board B362 A DESIGNER PEPTIDE TOXIN ISOLATED BY PHAGE DISPLAY THAT INHIBITS THE HUMAN VOLTAGE-GATED PROTON CHANNEL, HHV1. Kelleigh Kennedy , Ruiming Zhao, Qufei Li, Eduardo Perozo, Gerardo A. De Blas, Martin A. Pavarotti, Rodolfo Arias, Luis S. Mayorga, Steve A.N. Goldstein

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