Biophysical Society 61st Annual Meeting | Program Guide

Ligand-gated Channels I (Boards B375–B401)

2068-Pos Board B388 CHANNEL OPEN PROBABILITY CONTROLS ALLOSTERIC MODULATION OF POTENCY AND EFFICACY. Riley E. Perszyk , Kevin K. Ogden, Katie L. Strong, Dennis C. Liotta, Stephen F. Traynelis 2069-Pos Board B389 EFFECTS OF LIGAND CONFORMATIONS AND HETERO-LIGANDED STATES ON P2X2 RECEPTORS. Federica Gasparri , Jesper Wengel, Thomas Grutter, Stephan Pless 2070-Pos Board B390 POINT MUTANTS OF ATP-GATED P2X RECEPTORS CAST DOUBT ON THE INCLUSIVENESS OF THE RESERVOIR THEORY OF APPARENT PORE DILA- TION. Laura Janks 2071-Pos Board B391 INTERACTION OF PURINERGIC P2X4 AND P2X7 RECEPTOR SUB- UNITS. Fritz Markwardt , Markus Schneider, Kirsten Prudic, Anja Pippel, Manuela Klapperstück, Christa Müller, Michaela Stolz, Michaela Schum- acher, Günther Schmalzing 2072-Pos Board B392 A NOVEL, SPECTROSCOPIC WINDOW INTO NUCLEOTIDE ACTIVATION OF KATP CHANNELS. Michael C. Puljung , Natascia Vedovato, Frances M. Ashcroft 2073-Pos Board B393 INDEPENDENT ACTIVATION OF ION CONDUCTION PORES IN THE DOUBLE-BARRELED CA 2+ -ACTIVATED CL - CHANNEL TMEM16A. Andy K. M. Lam , Novandy K. Lim, Raimund Dutzler 2074-Pos Board B394 MUTAGENESIS STUDY OF THE CA 2+ SENSITIVITY OF SK2 CHANNELS. Young Woo Nam , Benjamin J. Whitmore, Razan S. Orfali, MIAO ZHANG 2075-Pos Board B395 ROLE OF INDIVIDUAL CAMP BINDING SITES ON RELIEVING THE AUTO- INHIBITION IN HCN CHANNELS. Mallikarjuna Rao Sunkara , Jana Kusch, Klaus Benndorf 2076-Pos Board B396 MONITORING THE CONFORMATIONAL CHANGES OF INDIVIDUAL CYCLIC NUCLEOTIDE-GATED ION CHANNELS BY HIGH-SPEED ATOMIC FORCE MICROSCOPY. Martina Rangl , Atsushi Miyagi, Julia Kowal, Henning Stahl- berg, Crina M. Nimigean, Simon Scheuring 2077-Pos Board B397 IDENTIFICATION OF AN ODORANT-BINDING SITE RESIDUE IN AN OLFAC- TORY RECEPTOR OF THE MALARIA VECTOR MOSQUITO. Suhaila Rahman , Charles W. Luetje 2078-Pos Board B398 MODULATING O2 PERMEABILITY OF THE CENTRAL PORE OF RH50 BY IN SILICO SITE DIRECTED MUTAGENESIS. Eric Shinn , Emad Tajkhorshid 2079-Pos Board B399 SYMMETRY MATCH IN DESIGN OF MULTIVALENT INHIBITORS OF ANTHRAX TOXIN. Sanaz Momben Abolfath , Halle Welch, Vladimir A Karginov, Ekaterina Nestorovich 2080-Pos Board B400 IDENTIFICATION AND ENERGETIC CHARACTERIZATION OF GAS PERME- ATION PATHWAYS THROUGH A PLANT WATER CHANNEL. Ahmad Raeisi Najafi , Paween Mahinthichaichan, Emad Tajkhorshid 2081-Pos Board B401 MODELING ION SELECTIVITY IN TRANSMEMBRANE DOMAIN OF THE NMDA RECEPTOR. Samaneh Sayede Mesbahi, Jon W. Johnson, Maria Kurnikova

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2055-Pos Board B375 IDENTIFICATION AND CHARACTERIZATION OF THE BINDING POCKET FOR NEGATIVE ALLOSTERIC MODULATORS IN AMPA RECEPTORS. Charlotte Stenum-Berg , Sergei C. Abiega, Christine L. Thisted, Anders S. Kristensen 2056-Pos Board B376 PHOSPHORYLATION IN AMPA RECEPTOR CARBOXY-TERMINUS: STRUC- TURE, FUNCTION, AND LIPID REGULATION. Caitlin E. Nurik , Suma Devi, Sana Shaikh, Drew Dolino, Darren Boehning, Vasanthi Jayaraman, James Howe 2057-Pos Board B377 MULTIPLE SUBCONDUCTANCE STATES OF TARPED AMPA RECEPTORS REVEALED BY SLOW DISSOCIATION OF ANTAGONIST. Ian Coombs, Andrij Tarasiuk, Lauren Marconi, Chris Shelley , Mark Farrant, Stuart G. Cull- Candy 2058-Pos Board B378 AMPA RECEPTOR MODULATION BY STARGAZIN. Sana A. Shaikh , DrewM. Dolino, Garam Lee, Sudeshna Chatterjee, David M. MacLean, Charlotte Flatebo, Christy F. Landes, Vasanthi Jayaraman 2059-Pos Board B379 DESIGN OF A GLUTAMATE-ACTIVATED POTASSIUM CHANNEL UPON FUSION OF THE LIGAND-BINDING DOMAIN OF THE MAMMALIAN AMPA RECEPTOR GLUA1 TO THE CHANNEL PORE OF THE VIRAL ATCV-1 KCV K + CHANNEL. Michael Schoenrock , Alina Poci, Gerhard Thiel, Bodo Laube 2060-Pos Board B380 CRYO-ELECTRON MICROSCOPY REVEALS STRUCTURAL BASIS OF KAINATE SUBTYPE GLUTAMATE RECEPTOR DESENSITIZATION. Sagar Chittori , Joel R. Meyerson, Alan Merk, Prashant Rao, Tae H. Han, Mihaela Serpe, Mark L. Mayer, Sriram Subramaniam 2061-Pos Board B381 REDUCED STRUCTURAL DYNAMICS IN KAINATE RECEPTORS THROUGH AUXILIARY PROTEIN MODULATION. Douglas B. Litwin , David M. Ma- cLean, Vasanthi Jayaraman 2062-Pos Board B382 FUNCTIONAL COUPLING OF BACTERIAL BINDING PROTEIN WITH THE CHANNEL PORE OF AN IONOTROPIC GLUTAMATE RECEPTOR. Max Bernhard , Bodo Laube 2063-Pos Board B383 PROBING THE CHANNEL GATING OF A GLUTAMATE RECEPTOR WITH PHOTOACTIVE UNNATURAL AMINO ACIDS. Mette Poulsen, Anahita Posh- tiban, Viktoria Klippenstein, Valentina Ghisi, Andrew Plested 2064-Pos Board B384 INVESTIGATING COUPLING BETWEEN PROTON SENSORS AND CHANNEL MOTIONS IN ACID-SENSING ION CHANNELS. Maria Musgaard , David M. MacLean, Douglas B. Litwin, Vasanthi Jayaraman, Philip C. Biggin 2065-Pos Board B385 ACID SENSING ION CHANNELS HAVE AGONIST-DEPENDENT DEACTIVA- TION. David M. MacLean , Vasanthi Jayaraman 2066-Pos Board B386 MOLECULAR BASIS FOR INHIBITION OF ACID-SENSING ION CHANNELS BY IBUPROFEN. Timothy Lynagh , Jose L. Romero-Rojo, Stephan A. Pless 2067-Pos Board B387 STOICHIOMETRY OF TOXIN BINDING TO ACID-SENSING ION CHAN- NELS. Christian B. Borg , Timothy Lynagh, Linda M. Haugaard-Kedström, Kristian Strømgaard, Stephan A. Pless

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